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# cms_nmn

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## Posts

- [Urolithin A Enhances Heartbeat in Healthy Human Cardiac Tissue, New Study Shows ](https://www.nmn.com/news/urolithin-a-enhances-contraction-and-relaxation-of-human-heart-tissue-new-kings-college-london-study-shows) - Urolithin A, a molecule usually produced by gut bacteria, enhances engineered human cardiac tissue while also counteracting heart failure in mice.
- [Oxygenaging: A New Framework Linking Oxygen Delivery, Mitochondria, and Aging](https://www.nmn.com/news/oxygenaging-a-new-framework-linking-oxygen-delivery-mitochondria-and-aging) - Oxygenaging points to oxygen utilization—from breathing down to cellular use—becoming dysregulated, serving as both a hallmark and driver of aging.
- [Semaglutide (Ozempic) Counters Lung Aging and Senescent Cells, New Study Shows](https://www.nmn.com/news/semaglutide-ozempic-counters-lung-aging-and-senescent-cells-new-study-shows) - Highlights Semaglutide counters lung scarring and increases the survival of mice that model age-related lung disease. At the cellular level, semaglutide reduces senescent cell markers and other markers of cellular and tissue damage. The effects of semaglutide were shown to be mediated by several factors, including enzymes called sirtuins, which depend on NAD+ to function.
- [Scientist’s Longevity Self-Experiment Reports Biological Age 15 Years Younger](https://www.nmn.com/news/scientists-longevity-self-experiment-reports-biological-age-15-years-younger) - Professor Dean Ho has a 15-year younger biological age than his chronological age and is conducting a longevity self-experiment.
- [AI Reveals How NMN and Mitochondrial Cleanup May Shape Brain Aging in New Study](https://www.nmn.com/news/ai-reveals-how-nmn-and-mitochondrial-cleanup-may-shape-brain-aging-in-new-study) - Highlights Brain genes related to NMN/nicotinamide adenine dinucleotide (NAD+) and mitochondrial cleanup are altered with age and in four neurodegenerative diseases. AI narrowed down the top five of these genes that drugs could target: ULK1, LAMP2, MFN1, OPA1, and ATP6V0E. In various models, these genes were shown to play a role in aging and neurodegeneration, suggesting that
- [Thymus-Derived Peptide Declines with Age & Restoring It Promotes Cancer Survival: New Study ](https://www.nmn.com/news/thymus-derived-peptide-declines-with-age-restoring-it-promotes-cancer-survival-new-usc-study) - Highlights In both mice and humans, the same pro-inflammatory immune cells increase with age. Combining the circulatory systems of aged and young mice reduces these pro-inflammatory immune cells. Treating mice that model breast cancer with thymulin delays tumor growth and increases survival. An immune system that has aged poorly can promote chronic inflammation, which contributes
- [Stem Cell-Derived Exosomes Restore Liver Function During Aging by Reviving the Cell's Recycling System ](https://www.nmn.com/news/stem-cell-derived-exosomes-restore-liver-function-during-aging-by-reviving-the-cells-recycling-system) - Stem cell-derived exosomes improve liver function and metabolism during aging by restoring autophagy, the cell’s natural recycling system.
- [Uridine Improves Egg Quality and Fertility During Aging: New Study Shows](https://www.nmn.com/news/uridine-improves-egg-quality-and-fertility-during-aging-new-study-shows) - Uridine supplementation improves egg quality, fertilization, embryo development, and fertility in aged mice by protecting eggs from cellular damage.
- [Bacteria-Derived Sugars May Help Preserve Female Fertility With Age, According to New Study](https://www.nmn.com/news/bacteria-derived-sugars-may-help-preserve-female-fertility-with-age-according-to-new-study) - Highlights A group of bacteria (called a genus) known as Lactobacillus declines in abundance with advancing reproductive age. A bacterium from this genus, L. gasseri, and the sugars it produces reduce the abundance of senescent (dysfunctional) cells in the lining of the uterus in aged mice. These findings position the sugar from L. gasseri as
- [NAD+ Supplement and Exercise Move Aging Clocks in Opposite Directions, New Study Shows ](https://www.nmn.com/news/nad-boosting-supplement-and-exercise-move-aging-clocks-in-opposite-directions-new-minerva-study-shows) - Nicotinamide riboside (NR) and high-intensity interval training (HIIT) move biological aging in opposite directions.
- [Ways to Counter Age-Related Muscle Loss and Cognitive Decline](https://www.nmn.com/news/ways-to-counter-age-related-muscle-loss-and-cognitive-decline) - Evidence suggests skeletal muscle communicates with the brain via myokine molecules, and dysfunctional communication with age leads to muscle decline and cognitive impairment.
- [Cell-Derived Vesicles Restore Memory and Reduce Brain Damage in Alzheimer’s, New Study Shows](https://www.nmn.com/news/cell-derived-vesicles-restore-memory-and-reduce-brain-damage-in-alzheimers-new-study-shows) - Researchers from UC Irvine show that extracellular vesicles improve memory and reduce brain damage in an Alzheimer’s mouse model.
- [Seragon’s Breakthrough Longevity Candidate SRN-901 Dramatically Increases Lifespan and Healthspan in Preclinical Study](https://www.nmn.com/news/seragons-breakthrough-longevity-candidate-srn-901-dramatically-increases-lifespan-and-healthspan-in-preclinical-study) - Seragon Biosciences has completed one of the most comprehensive preclinical studies to date, finding that its aging intervention candidate SRN-901 drastically prolongs lifespan and healthspan.
- [Mice Emit Light When Alive but Not Dead: What Does This Mean for Aging?](https://www.nmn.com/news/mice-emit-light-when-alive-but-not-dead-what-does-this-mean-for-aging) - Ultra-weak light emitted from all living organisms could one day be used to diagnose, or maybe even treat, chronic diseases of aging.
- [Citrus Fruit Peel Molecule Improves Skin and Counters Cell Senescence, New Study Shows](https://www.nmn.com/news/citrus-fruit-peel-molecule-improves-skin-and-counters-cell-senescence-new-study-shows) - A molecule called hesperetin reduces skin aging from both UV light and natural aging in mice, and there is evidence for this working in humans.
- [New Study Reveals How a Next-Generation Supplement May Slow Multi-Organ Aging](https://www.nmn.com/news/new-study-reveals-how-a-next-generation-supplement-may-slow-multi-organ-aging) - Piceatannol lowers cell senescence and systemic inflammation, while improving motor coordination and memory in a mouse model of aging.
- [New Study: Berberine Protects the Heart by Increasing Klotho, a Pro-Longevity Protein](https://www.nmn.com/news/new-study-berberine-protects-the-heart-by-increasing-klotho-a-pro-longevity-protein) - A new study shows that berberine eliminates the susceptibility to abnormal heartbeats in obese rats and requires the pro-longevity protein Klotho to do so.
- [NMN Activates Sirtuins to Combat Cardiovascular Aging, New Study Shows](https://www.nmn.com/news/nmn-activates-sirtuins-to-combat-cardiovascular-aging-new-study-shows) - The NAD+ (nicotinamide adenine dinucleotide) precursor NMN (nicotinamide mononucleotide) mitigates aneurysm development in mice and fuels the age-associated enzyme sirtuin-7.
- [Apigenin Supplement Improves Heart Function in Lab Rats, New Study Shows](https://www.nmn.com/news/apigenin-supplement-improves-heart-function-in-lab-rats-new-study-shows) - #post_excerptApigenin improves the heart function of rats by targeting multiple drivers of aging, including inflammation.
- [Human Trial Shows Ginseng Compound Increases Muscle Mitochondria After Exercise in Aged Women](https://www.nmn.com/news/human-trial-shows-ginseng-compound-increases-muscle-mitochondria-after-exercise-in-aged-women) - Highlights One hour after ingesting 10 mg of Rg1, older women completed four sets of leg presses, which increased the number of stem cells with high mitochondrial content in their muscles. Stem cells deliver mitochondria to muscle fibers to replenish their cell energy-generating capacity. While exercise alone reduced circulating levels of sex hormones, Rg1 restored
- [Creatine Powers Immune Cells Against Cancer in New UCLA Study  ](https://www.nmn.com/news/creatine-powers-immune-cells-against-cancer-in-new-ucla-study) - #post_excerptUniversity of California, Los Angeles (UCLA) scientists find that creatine improves the capacity of immune cells to combat tumors in mice.
- [Scientists Discover How to Regrow  Fingers: What It Means for Aging](https://www.nmn.com/news/biological-breakthrough-scientists-discover-how-to-regrow-fingertip-tissues) - Scientists have found how to regenerate the fingertips of mice, raising the question of whether the technology can lead to improved health and longevity.
- [GLP-1 Boosting Fiber Suppresses Appetite to Counter Weight Gain, Approved for Use in Food](https://www.nmn.com/news/a-fiber-that-helps-suppress-appetite-to-counter-weight-gain-approved-for-use-in-food) - The fiber inulin propionate ester, which suppresses appetite to counter long-term weight gain, has been approved as safe for human consumption in Europe.
- [AI and Genetics Join Forces to Map the Molecular Roots of Aging — and Find Drugs That May Already Treat Them](https://www.nmn.com/news/ai-and-genetics-join-forces-to-map-the-molecular-roots-of-aging-and-find-drugs-that-may-already-treat-them) - A new AI-guided pipeline identifies 45 aging-associated targets and approved drugs that target them for aging intervention.
- [New Study Explains How NR Supplement Improves Memory](https://www.nmn.com/news/new-study-explains-how-nr-supplement-improves-memory) - The NAD+ precursor NR improves the memory of Alzheimer’s mice by counteracting the accumulation of age-promoting senescent cells.
- [Harvard Geneticist Says We May Be in the Middle of a Longevity Revolution](https://www.nmn.com/news/harvard-geneticist-says-we-may-be-in-the-middle-of-a-longevity-revolution) - Harvard's George Church cannot rule out that humans have reached longevity escape velocity, when lifespan-extending advancements outpace life expectancy.
- [New Study: Alpha-Ketoglutarate Shows Potential to Lower Biological Age in Humans](https://www.nmn.com/news/new-study-alpha-ketoglutarate-shows-promise-to-lower-biological-age-in-humans) - Highlights Supplement users in the study used an average of about four supplements, and they showed a significantly lower biological age compared to participants who did not use supplements. Among the supplements taken, those who took a delayed-release alpha-ketoglutarate supplement showed the most significantly lowered biological age. In a study published in Aging Cell, Brian
- [UC Irvine Scientists Restore Age-Related Vision Loss With a Naturally Occurring Retinal Lipid ](https://www.nmn.com/news/uc-irvine-scientists-restore-age-related-vision-loss-with-a-naturally-occurring-retinal-lipid) - Restoring a naturally occurring retinal lipid improves visual function and reduces age-related retinal damage in mice, researchers find.
- [Fisetin Reverses Premature Blood Vessel Aging Caused by Chemotherapy ](https://www.nmn.com/news/fisetin-reverses-premature-blood-vessel-aging-caused-by-chemotherapy) - Study finds that fisetin restores healthy blood vessel function and reduces signs of premature aging caused by chemotherapy.
- [New Brain Aging Study Questions the Role of Common Omega-3](https://www.nmn.com/news/new-brain-aging-study-questions-the-role-of-common-omega-3) - Scientists find that EPA (eicosapentaenoic acid), an omega-3 fatty acid found in fish oil, impairs brain healing after injury in mice.
- [Exploring the Potential of a Molecule in Peppers to Slow Vascular Aging](https://www.nmn.com/news/exploring-the-potential-of-a-molecule-in-peppers-to-slow-vascular-aging) - A spicy molecule found in certain kinds of peppers called capsaicin may mitigate vascular aging.
- [Citrulline Supplementation Reduces Inflammation and Reverses Aging Markers in Aged Mice ](https://www.nmn.com/news/citrulline-supplementation-reduces-inflammation-and-reverses-aging-markers-in-aged-mice) - Highlights Citrulline levels decline with age across multiple tissues. Restoring citrulline reduces inflammation and cellular damage. Citrulline improves immune function and reverses aging markers in mice. Aging is associated with changes in how the body processes and uses nutrients. Some naturally occurring molecules increase over time, while others steadily decline. Although many of these shifts
- [Inexpensive FDA-Approved Drug Prolongs the Life of Mice, New Study Shows](https://www.nmn.com/news/inexpensive-fda-approved-drug-prolongs-the-life-of-mice-new-study-shows) - Mianserin (MIA) moderately prolongs the lifespan of naturally aged mice while countering decrements in movement, hair, and other signs of aging.
- [Longevity Protocol for Harvard’s David Sinclair in 2026](https://www.nmn.com/news/longevity-protocol-for-harvards-david-sinclair-in-2026) - David Sinclair’s updated longevity protocol for 2026 is largely rooted in the Information Theory of Aging—the notion that a loss of epigenetic information drives aging.
- [Scientists Identify a New Natural Senolytic that Counters Physical Aging](https://www.nmn.com/news/scientists-identify-a-new-natural-senolytic-that-counters-physical-aging) - Rhodiola rosea improves the physical capacity of middle-aged mice and reduces hair loss, hair graying, and skin decline in aged mice.
- [China's New Standardized, Longevity-Focused Preventive Medicine Presents Competition for US](https://www.nmn.com/news/china-outpaces-the-us-with-new-standardized-longevity-focused-preventative-medicine) - China has launched a standardized educational program for physicians that focuses on longevity to address an aging population and growing healthcare costs.
- [Panax Ginseng Compound May Help Prevent Age-Related Muscle Loss (Sarcopenia)](https://www.nmn.com/news/panax-ginseng-compound-may-help-prevent-age-related-muscle-loss-sarcopenia) - Highlights In laboratory dishes, ginsenoside Ro reduced muscle cell senescence (a state where cells stop dividing yet remain metabolically active). In a mouse model of age-associated sarcopenia, ginsenoside Ro increased muscle mass and enhanced physical endurance. Additionally, ginsenoside Ro restored cellular energy production in muscles. Sarcopenia, a disorder strongly correlated with aging, is characterized by
- [The New "Tri-Axis" Anti-Aging Model: Why NMN, PQQ, and EGT Work Better Together](https://www.nmn.com/news/the-new-tri-axis-anti-aging-model-why-nmn-pqq-and-egt-work-better-together) - Why single supplements often fail—and how NMN, PQQ, and ergothioneine may restore mitochondrial health.
- [Supplement Pair Boosts Muscle Mass and Endurance, New Study Shows](https://www.nmn.com/news/longevity-supplement-combo-boosts-muscle-mass-and-endurance-new-study-shows) - Highlights Of eight dietary fiber types, FOS most greatly increases the beneficial gut bacteria metabolite urolithin A. FOS combined with the urolithin A precursor EA synergistically increases endurance and muscle mass. The combo also synergistically increases mitophagy—a key cellular process that counteracts biological aging. As we age, our muscles shrink, and the beneficial bacteria living Fiber with ellagic acid elevates urolithin A and improves muscle mass only when combined.
- [Alpha-Ketoglutarate Protects Against Brain Aging, New Study Shows](https://www.nmn.com/news/life-extending-molecule-alpha-ketoglutarate-protects-against-brain-aging-new-study-shows) - Highlights Alpha-ketoglutarate restores the memory formation capacity of mice that model brain aging. When combined with another life-extending molecule called rapamycin, alpha-ketoglutarate may have more potent effects on memory formation capacity. Alpha-ketoglutarate enhances a key process for brain health, known as autophagy, in mice that model brain aging. At any given moment, measurable electrical currents Alpha-ketoglutarate improves memory formation capacity.
- [Anti-Aging Senolytics Slow Bone Loss but Not Gum Disease](https://www.nmn.com/news/anti-aging-senolytics-slow-bone-loss-but-not-gum-disease) - Study shows that dasatinib and quercetin reduce inflammation and prevent age-related alveolar bone loss in mice, supporting healthier aging gums.
- [Fisetin May Revitalize the Vascular System, According to New Study](https://www.nmn.com/news/fisetin-may-revitalize-the-vascular-system-according-to-new-study) - A new study shows fisetin selectively eliminates senescent vascular cells and enhances vascular function in old mice.
- [GLP-1 Drug Alleviates Age-Related Dry Eye Disease, New Study Shows](https://www.nmn.com/news/glp-1-drug-alleviates-age-related-dry-eye-disease-new-study-shows) - Scientists find that the GLP-1 drug, semaglutide, alleviates dry eye and modulates age-promoting senescent cells in aged mice.
- [Latest Findings: Vesicles Delivering NMN-Synthesizing Enzyme Counteract Age-Related Liver Disease](https://www.nmn.com/news/latest-findings-vesicles-delivering-nmn-synthesizing-enzyme-counteract-age-related-liver-disease) - Highlights In a mouse model of an age-related liver disease, exercise alleviated a fatty liver, inflammation, a condition where cells do not respond effectively to insulin (insulin resistance), and liver scarring. As a primary mediator of these effects, scientists identified vesicles with high levels of eNAMPT circulating in exercised mice. These findings reveal a novel
- [New Harvard Study: AI Estimates Rate of Aging with Facial Photos](https://www.nmn.com/news/new-harvard-study-ai-estimates-rate-of-aging-with-facial-photos) - Scientists have developed a way to use an AI algorithm that predicts biological age from facial photographs to estimate the rate of aging and predict survival.
- [Tomato Compound Improves Memory: New Mayo Clinic Study](https://www.nmn.com/news/tomatidine-tomato-compound-improves-memory-new-mayo-clinic-study) - Tomatidine, a compound found in green tomatoes, improves memory, counters frailty, and reduces age-promoting senescent cells in mice.
- [Top Anti-Aging Habits from a Danish Longevity Doctor](https://www.nmn.com/news/top-anti-aging-habits-from-a-danish-longevity-doctor) - A Danish longevity expert, Morten Scheibye-Knudsen, takes an NAD+ precursor and metformin and stays physically active to ward off the effects of aging.
- [NMN Enhances REM Sleep Brain Waves, New Study Shows](https://www.nmn.com/news/nmn-enhances-rem-sleep-brain-waves-new-study-shows) - Scientists find that NMN increases the brain waves associated with REM sleep.
- [New Study: Immune-Stimulating Therapy Reduces Body Fat and Enhances Muscles](https://www.nmn.com/news/new-study-immune-stimulating-therapy-reduces-body-fat-and-enhances-muscles) - A therapy that elicits an immune response against the protein myostatin reduces age-related weight gain and increases muscle mass in mice.
- [Proline for Muscle Health: New Study on Rejuvenating Stem Cells](https://www.nmn.com/news/proline-for-muscle-health-new-study-on-rejuvenating-stem-cells) - Restoring the amino acid proline in aged stem cells rejuvenates their muscle tissue-regenerating capacity.
- [NMN + Apigenin Stack Promotes Multi-Tissue Regeneration: New Research](https://www.nmn.com/news/nmn-apigenin-stack-promotes-multi-tissue-regeneration-new-research) - Combining NMN with apigenin produces an additive effect that regenerates tissues and enhances physical capacity in aged mice.
- [Scientists Prolong the Life of Mice With Invisible Energy Fields, New Study Shows](https://www.nmn.com/news/scientists-prolong-the-life-of-mice-with-invisible-energy-fields-new-study-shows) - Electromagnetic fields (EMFs) trigger an anti-aging process known as cyclic cellular reprogramming in mice to extend their health and longevity.
- [Seragon Reports Record-Breaking Data on SRN-901, a New Drug That Extends Mouse Lifespan by 33%](https://www.nmn.com/news/seragon-reports-record-breaking-data-on-srn-901-a-new-drug-that-extends-mouse-lifespan-by-33) - A multi-component drug candidate increased lifespan by 33%, slowed frailty progression, and reduced tumor incidence.
- [Combining Three Supplements at Low Doses Shown to Delay Age-Related Bone and Muscle Decline](https://www.nmn.com/news/combining-three-supplements-at-low-doses-shown-to-delay-age-related-bone-and-muscle-decline) - A combination of β-hydroxy-β-methylbutyrate, colostrum basic protein, and hyaluronic acid preserves muscle, exercise performance, and bone in aged mice.
- [NMN Limits the Initiation of Precancer, According to New Study](https://www.nmn.com/news/nmn-limits-the-initiation-of-precancer-according-to-new-study) - NMN (nicotinamide mononucleotide) mitigates the conversion of stomach cells into intestinal-like cells, which may potentially reduce the risk of stomach cancer.
- [Aging Amplifies Liver Damage From Fatty Diets, Study Finds – But Rapamycin Reverses It](https://www.nmn.com/news/aging-amplifies-liver-damage-from-fatty-diets-study-finds-but-rapamycin-reverses-it) - A new study shows aging makes the liver more vulnerable to high-fat diets, but rapamycin may reverse inflammation, restore metabolic function, and reduce fatty liver damage.
- [Hearing Loss Prevented by Anti-Aging Supplement Quercetin: New Study](https://www.nmn.com/news/hearing-loss-prevented-by-anti-aging-supplement-quercetin-new-study) - Discover how quercetin, a plant-based polyphenol, may reduce age-related hearing loss by combating inflammation and supporting cochlear health.
- [Foods Lacking Fiber Destroy Emotional Memories, New Study Shows](https://www.nmn.com/news/the-aged-brains-fear-center-is-particularly-susceptible-to-processed-foods-new-study-finds) - Highlights The aged brain is particularly vulnerable to fear-based memory impairments induced by processed food. Processed food also triggers mitochondrial dysfunction in the aged but not the young brain. Processed food reduces circulating short-chain fatty acids—signaling molecules from the gut microbiome that improve brain and mitochondrial health. As the scientific evidence accumulates, it is now Consuming processed food may lead to bad life decisions.
- [Max Planck Institute Scientists Show NAD+ Controls Heart Circadian Rhythm During Aging](https://www.nmn.com/news/max-planck-institute-scientists-show-nad-controls-heart-circadian-rhythm-during-aging) - Max Planck Institute researchers show that NAD+ levels regulate the heart's circadian rhythm during aging and that NR prevents age-related cardiac enlargement.
- [Can Fish Oil Fix a Bad Diet? New Science on Protecting Cells from Junk Food](https://www.nmn.com/news/fish-oil-counteracts-aging-effects-of-junk-food-new-study) - Highlights Fish oil reduces “bad” cholesterol, blood glucose levels, and weight gain in mice that eat fried food every day. Fish oil also counteracts the liver and metabolic dysfunction induced by excessive fried food consumption. Fish oil restores balance to the gut microbiome, which may contribute to the above benefits. The process of frying foods Fish oil supplement counteracts age-accelerating effects of processed food.
- [New Oxford Study: Life Extending Drug Rapamycin Rejuvenates Immune System](https://www.nmn.com/news/life-extending-drug-rapamycin-protects-against-dna-damage-new-oxford-study) - Highlights Inhibiting mTOR reduces DNA damage in vital white blood cells called T cells. Rapamycin, which inhibits mTOR, doubles the survival rate of T cells. Supplementing with rapamycin reduces T cell DNA damage in older adults. Of all the anti-aging interventions, mTOR inhibition is the most well-established to date. Inhibiting mTOR has been shown to Inhibiting mTOR (mechanistic target of rapamycin) counteracts DNA damage and immune system aging in humans.
- [Reversing The Silent Driver of Aging with Pigment Supplement: New Clinical Trial](https://www.nmn.com/news/reversing-signs-of-insulin-resistance-with-anthocyanin-new-clinical-trial) - Highlights Signs of insulin resistance were reversed or reduced by anthocyanin supplementation in middle-aged and older adults. In the skin, anthocyanin supplementation reduced the toxic accumulation of molecules that promote insulin resistance. Insulin resistance (IR) has been called the Eminence Grise—the unseen but powerful driver—of aging. It underlies a plethora of age-related conditions, including type Plant-based pigments counteract early signs of diabetes in adults.
- [What 82-Year-Old Mick Jagger of the Rolling Stones Does to Defy Advanced Age](https://www.nmn.com/news/what-82-year-old-mick-jagger-of-the-rolling-stones-does-to-defy-advanced-age) - At age 82, Mick Jagger continues to defy aging by eating organic foods, not drinking alcohol, and adhering to a vigorous workout routine.
- [NMN and 78c: A New Synergy for Treating Dry Eye and Aging](https://www.nmn.com/news/nmn-and-78c-a-new-synergy-for-treating-dry-eye-and-aging) - Highlights The NAD+- and NMN-degrading enzyme CD38 is elevated in the eyelids of older adults. In mice, the elevation in CD38 is associated with oil gland dysfunction, contributing to dry eye pathology. NMN enhances the effects of 78c, which inhibits CD38, in restoring oil gland function in aged mice. From heart disease to dementia, many NMN enhances the effect of 78c against age-related dry eye.
- [New Pilot Human Trial Supports Probiotics Improving Mental Well-Being in the Elderly](https://www.nmn.com/news/new-pilot-human-trial-supports-probiotics-improving-mental-well-being-in-the-elderly) - A strain of the probiotic Lactiplantibacillus plantarum lowered a marker of gut inflammation and enhanced scores on an assessment of well-being in older adults.
- [NMN Counteracts Muscle and Liver Aging In New Multi-Study Analysis](https://www.nmn.com/news/nmn-counteracts-muscle-and-liver-aging-in-new-multi-study-analysis) - Highlights NMN improves walking speed, according to an analysis of 8 trials. NMN improves insulin sensitivity, but only at low doses, according to an analysis of 4 trials. NMN reduces a marker for liver injury, ALT, according to an analysis of 6 trials. NMN is a precursor to NAD+ (nicotinamide adenine dinucleotide) and, when consumed, NMN improves signs of muscle and liver function.
- [The Vitalists Explained: A Longevity Movement Aiming to Shape Politics](https://www.nmn.com/news/the-vitalists-explained-a-longevity-movement-aiming-to-shape-politics) - The Vitalists is a group of hardcore longevity enthusiasts seeking a revolution to make defeating death society’s number one priority.
- [Scientists Unveil Results from Human Trial Directly Comparing Three NAD+ Precursors](https://www.nmn.com/news/scientists-unveil-results-from-human-trial-directly-comparing-three-nad-precursors) - Oral supplementation with NR or NMN sustainably doubles circulating NAD+, while supplementation with Nam does not.
- [The Secret to Delaying Aging and Treating Chronic Stress: New Theory](https://www.nmn.com/news/preventing-premature-aging-by-reducing-chronic-stress-new-theory) - Highlights Stress allocates the cellular energy produced by mitochondria to processes that are not conducive to aging normally. Cultivating the activation of the parasympathetic nervous system allows energy to be expended on restorative cellular processes that counteract aging. “We must continuously breathe precisely to bring oxygen to mitochondria…” — Cromwell and colleagues. Mitochondria—the cellular organs Breathing slowly can slow cellular aging.
- [Urolithin A vs Spermidine for Longevity: Benefits, Pathways, and Differences](https://www.nmn.com/news/urolithin-a-vs-spermidine-for-longevity-benefits-pathways-and-differences) - Spermidine may work better to target general longevity better than urolithin A, while urolithin A may work better for metabolism and muscle function.
- [New Study Finds Astronauts May Be Ideal Aging Models for Therapeutic Testing](https://www.nmn.com/news/new-study-finds-astronauts-may-be-ideal-aging-models-for-therapeutic-testing) - Highlights Using 32 different assessments, scientists found that biological age acceleration increased by an average of 1.91 years after seven days of spaceflight. Upon returning to Earth, biological age decreased in all crew members, closer to pre-flight values. The findings suggest that astronauts in space may serve as valuable aging models on which to test
- [Scientists Uncover Evidence That Molecule Released During Exercise, Also Available as a Supplement, Slows Cognitive Decline with Age](https://www.nmn.com/news/brain-aging-breakthrough-molecule-available-as-a-supplement-linked-to-exercises-cognitive-benefits) - A new study provides evidence that supplementing with β-hydroxybutyrate mimics the cognition-enhancing effects associated with exercise in old mice.
- [Calorie Restriction Preserves Brain White Matter by Slowing Cellular Aging: New Study Shows](https://www.nmn.com/news/calorie-restriction-preserves-brain-white-matter-by-slowing-cellular-aging-new-study-shows) - A new primate study shows long-term calorie restriction preserves brain white matter by slowing age-related changes in oligodendrocytes and microglia.
- [New Aging Theory Helps Build the Case for Devices That Activate Key Nerve](https://www.nmn.com/news/https-www-nmn-com-news-new-aging-theory-helps-build-the-case-for-devices-that-deliver-electrical-impulses-through-the-skin) - Scientists propose that an age-related overactivation of a collection of nerves that trigger a “fight or flight” response facilitates processes of aging, yet vagus nerve stimulation may counter this.
- [How Soviet-Era Scientists Helped Lay the Foundation for Modern Aging Research](https://www.nmn.com/news/how-soviet-era-scientists-laid-the-foundation-for-modern-aging-research) - A reflective essay published in Aging shares how Soviet-era scientists shaped modern conceptions of the mechanisms of aging.
- [Stem Cell–Derived Vesicles Rejuvenate Pancreas Cells and Cure Age-Related Diabetes ](https://www.nmn.com/news/stem-cell-derived-vesicles-rejuvenate-pancreas-cells-and-cure-age-related-diabetes) - Stem cell–derived vesicles rejuvenate aging pancreatic β cells, restore insulin secretion, and reverse diabetes in old mice by reducing cellular senescence and improving mitochondrial function.
- [Are We Misunderstanding Aging? A New Look at Life-Extending Interventions](https://www.nmn.com/news/are-we-misunderstanding-aging-a-new-look-at-life-extending-interventions) - Preventing mitochondrial dysfunction as the root cause of aging.
- [Engineering the Future: The AI Revolution in Aging Science](https://www.nmn.com/news/engineering-the-future-the-ai-revolution-in-aging-science) - Scientists propose urban communities where real-time health data from residents is continuously analyzed with AI for longevity research.
- [New Stem Cell–Derived Immune Cells Reverse Memory Loss in Aging and Alzheimer’s Brains](https://www.nmn.com/news/human-stem-cell-derived-immune-cells-improve-cognition-and-brain-health-in-aging-and-alzheimers-mice) - Stem cell–derived immune cells improved memory and brain health in aging and Alzheimer’s mice by reducing inflammation and supporting neural repair.
- [Emerging Therapy Reverses Memory Loss and Boosts Brain Connectivity in Aged Monkeys](https://www.nmn.com/news/emerging-therapy-reverses-memory-loss-and-boosts-brain-connectivity-in-aged-monkeys) - Highlights Stem cell vesicles reverse age-related memory impairments in monkeys. The improvements in memory are associated with increased brain connectivity. We reiterate the role of NMN in the efficacy of stem cell vesicle therapy. Picture a dog and a rabbit. Now imagine them racing each other. Easy enough? Now add a cat to the race. An emerging and innovative therapy reverses memory loss in monkeys.
- [Exploring NMN Human Trial Advancements](https://www.nmn.com/news/exploring-recent-nmn-human-trial-advancements) - Highlights Throughout NMN human trials from the past three years, the NAD+ precursor hasn’t triggered any adverse physiological effects, confirming its safety.Human trials show NMN’s beneficial effects of enhancing insulin sensitivity and increasing physical capacity in aged adults. NMN is a precursor for the essential, pro-longevity molecule nicotinamide adenine dinucleotide (NAD+) and has come under
- [Protein Supplement Extends Life, Boosts Strength, and Reduces Biological Age, According to New Study](https://www.nmn.com/news/protein-supplement-extends-life-boosts-strength-and-reduces-biological-age-according-to-new-study) - Highlights Supplementing with collagen-related amino acids, in the correct ratio, prolongs the lifespan of worms more than collagen supplementation. The collagen-related amino acids reduce fat and increase strength in mice. In humans, the collagen-related amino acids lower biological age and improve skin. Scientists are finding that collagen levels decline with age, resulting in skin, bone, Collagen-related amino acids extend lifespan, boosts strength, and reduces biological age.
- [A 100-Year-Old Bodybuilder Credits a Purpose-Driven Life for Exceptional Longevity](https://www.nmn.com/news/a-100-year-old-bodybuilder-credits-a-purpose-driven-life-for-exceptional-longevity) - A 100-year-old bodybuilder named Andrew Bostinto reflects on his humble beginnings and the progress he has made throughout his life as motivation to stay in shape for longevity.
- [GLP-1 Drug Counteracts Aging Independent of Weight Loss in New Study](https://www.nmn.com/news/glp-1-drug-counteracts-aging-independent-of-weight-loss-in-new-study) - Highlights Exenatide counteracts physical but not mental decline, and promotes anxiety. Exenatide does not cause body weight loss or suppress appetite, but reduces visceral fat. Compared to rapamycin, exenatide similarly alters genes in multiple tissues. According to some researchers, the ideal anti-aging method will have: A good safety profile and wide therapeutic dose range. Broad GLP-1 receptor agonist exenatide counters aging in multiple organs and tissues.
- [Gene Therapy for Aging: New Advances That Could Extend Lifespan](https://www.nmn.com/news/gene-therapy-for-aging-new-advances-that-could-extend-lifespan) - The CEO of a biotech company shares promising data on anti-aging gene therapies meant to extend telomeres, boost muscle function, and improve cognition.
- [Huberman and Fajgenbaum Sound the Alarm on America's Forgotten Anti-Aging Drugs](https://www.nmn.com/news/andrew-huberman-and-david-fajgenbaum-explain-how-common-medicines-influence-human-longevity) - Andrew Huberman and David Fajgenbaum explore how everyday medicines, inflammation, sleep, and stress influence aging biology and long-term health.
- [Vitamin C Counteracts Reproductive Aging, New Study Shows](https://www.nmn.com/news/vitamin-c-counteracts-reproductive-aging-in-monkeys-new-study-shows) - Highlights Vitamin C supplementation rejuvenates the aging ovaries of monkeys, increasing indicators of fertility. The essential vitamin reduces the biological age of multiple cells found in the ovaries, including oocytes. Vitamin C contributes to the elimination of age-promoting senescent cells while combating several other biological drivers of aging. Scientists are quickly gaining an understanding of Vitamin C counteracts reproductive aging in female monkeys.
- [New Insights on Muscle Strength: The Role of Inhibiting an Enzyme that Hinders NAD+ Synthesis](https://www.nmn.com/news/new-insights-on-muscle-strength-the-role-of-inhibiting-an-enzyme-that-hinders-nad-synthesis) - The NNMT inhibitor 5-amino-1MQ, which may work to increase cellular NAD+, improves strength and endurance in aged mice and may serve to counter age-related muscle deterioration.
- [Huberman Lab Essentials: “The Biology of Slowing & Reversing Aging” with David Sinclair](https://www.nmn.com/news/huberman-lab-essentials-the-biology-of-slowing-reversing-aging-with-david-sinclair) - Highlights Sinclair’s Information Theory of Aging posits that aging is caused by a loss of (epi)genetic information. We can push back against cellular aging by targeting two key cellular pathways: the sirtuin pathway and the mTOR pathway. We can target these pathways by fasting or with supplements that boost NAD+ levels, such as NMN. The A summary of the Huberman Lab Essentials episode with David Sinclair.
- [New Study: NMN Supplement Mitigates Neurotoxicity Induced by Household Products](https://www.nmn.com/news/new-study-nmn-supplement-mitigates-neurotoxicity-induced-by-household-products) - Highlights Phthalate exposure triggers the breakdown of the protective structure surrounding the central nervous system. Supplementing with NMN mitigates the breakdown of this structure while reducing inflammation. NMN supplementation counteracts cognitive and emotional impairments induced by phthalate exposure. Many of us were born into a world of plastic—synthetic polymers made from fossil fuels. Such a NMN reduces cognitive deficits and brain damage induced by phthalates in mice.
- [Umbilical Cord Stem Cells Restore Brain Function and Reverse Age-Related Cognitive Decline: New Study Shows](https://www.nmn.com/news/umbilical-cord-stem-cells-restore-brain-function-and-reverse-age-related-cognitive-decline-new-study-shows) - Umbilical cord stem cells restore brain function in aged mice by correcting microglial metabolism, reducing inflammation, and improving memory performance.
- [Joe Rogan and Gary Brecka Share Key Insights into Human Longevity](https://www.nmn.com/news/joe-rogan-and-gary-brecka-share-key-insights-into-human-longevity) - Joe Rogan and Gary Brecka break down the science behind living longer, covering gene editing, fasting, AI diagnostics, and functional medicine.
- [Diabetes Drug Henagliflozin Shows Signs of Slowing Biological Aging in Clinical Trial](https://www.nmn.com/news/diabetes-drug-henagliflozin-shows-signs-of-slowing-biological-aging-in-clinical-trial) - Trial shows that henagliflozin, a diabetes drug, lengthened telomeres and improved aging biomarkers in patients with type 2 diabetes after 26 weeks of treatment.
- [Popular Longevity Drug Rapamycin Doesn’t Stop You From Building Muscle](https://www.nmn.com/news/popular-longevity-drug-rapamycin-doesnt-stop-you-from-building-muscle) - Study shows that rapamycin does not block exercise-driven muscle and endurance gains in female mice, though frequent dosing impairs blood sugar control.
- [Dr. Peter Attia and Longevity Expert Brian Kennedy Reveal Aging Secrets](https://www.nmn.com/news/peter-attias-longevity-podcast-with-brian-kennedy-reveals-what-may-actually-slow-aging) - Biologist Brian Kennedy joins Peter Attia to discuss rapamycin trials, aging models, biological clocks, and lifestyle tools that may extend human healthspan.
- [Psilocybin Increases Cellular Lifespan and Boosts Survival in Aged Mice](https://www.nmn.com/news/natural-compound-increases-cellular-lifespan-and-boosts-survival-in-aged-mice) - New research shows low-dose psilocybin extends cellular lifespan by up to 57%, preserves telomeres, reduces senescence, and boosts survival in aged mice.
- [Stanford Scientists Identify Molecule That Rejuvenates Stem Cells and Restores Strength in Aging Muscles](https://www.nmn.com/news/stanford-scientists-identify-molecule-that-rejuvenates-stem-cells-and-restores-strength-in-aging-muscles) - A single dose of a natural hormone analog restores strength and stem cell function in aged muscle, offering hope for reversing age-related decline.
- [Taurine Reverses Pancreatic Aging, Offering Hope for Type 2 Diabetes](https://www.nmn.com/news/taurine-reverses-pancreatic-aging-offering-hope-for-type-2-diabetes) - New study shows that prostaglandin E₂ (PGE₂) can restore strength and regeneration in aged muscle by rebooting stem cell function.
- [Daily Vitamin D Supplementation Slows Cellular Aging: New Trial Finds](https://www.nmn.com/news/daily-vitamin-d-supplementation-slows-cellular-aging-new-trial-finds) - A new analysis from the VITAL study suggests daily vitamin D₃ supplementation may help slow cellular aging by reducing telomere shortening in white blood cells.
- [Senolytic Drug Halts GI Cancer Progression: New Study Shows](https://www.nmn.com/news/senolytic-drug-shows-promise-in-preventing-gi-cancer-new-study-shows) - New study shows the senolytic drug ABT-263 reduces radiation-induced gastrointestinal tumors in mice by clearing senescent cells and reducing inflammation.
- [New Trial Links Combo Supplement to Increased Strength and Reduced Biological Age ](https://www.nmn.com/news/new-trial-links-combo-supplement-to-increased-strength-and-reduced-biological-age) - A year-long study of the Cel System supplement stack shows improved strength, reduced waist size, and slowed biological aging in adults.
- [Young Stem Cell Vesicles Rejuvenate the Aging Heart: New Study Finds](https://www.nmn.com/news/young-stem-cell-vesicles-rejuvenate-the-aging-heart-new-study-finds) - A new study reveals that tiny vesicles secreted by young stem cells can reverse multiple signs of cardiac aging in mice.
- [Harvard’s David Sinclair: Nail Growth Reveals How Aged Your Body Really Is](https://www.nmn.com/news/harvards-david-sinclair-says-to-monitor-nail-growth-to-gauge-how-fast-youre-aging) - Research highlighted by Harvard’s David Sinclair shows that nail growth declines by 0.5% per year after age 25, suggesting it may serve as a measurable indicator of biological aging.
- [Senolytic Treatment Rejuvenates Aging Skin and Enhances Wound Healing: New Study Reveals](https://www.nmn.com/news/scientists-discover-senolytic-treatment-that-rejuvenates-aging-skin-and-enhances-wound-healing) - Researchers discovered that the senolytic compound ABT-263 eliminates aging skin cells, reduces inflammation, and accelerates wound healing.
- [Scientists Discover a Way to Combat Muscle Loss in Aging Dogs](https://www.nmn.com/news/scientists-discover-a-way-to-combat-muscle-loss-in-aging-dogs) - Researchers find that ursolic acid reduces muscle atrophy in aging dogs, improving mobility and exercise performance after 60 days of supplementation.
- [New Findings Reveal Urolithin A Can Help Thwart Alzheimer's: A Remarkable Discovery](https://www.nmn.com/news/new-findings-reveal-urolithin-a-can-help-thwart-alzheimers-a-remarkable-discovery) - Urolithin A enhances learning and memory, mitigates Alzheimer's hallmarks, and protects mitochondria in mice modeling Alzheimer's disease.
- [The Magic of Longevity Mushrooms: Ergothioneine’s Remarkable Impact on Lifespan and Cognitive Enhancement](https://www.nmn.com/news/the-magic-of-longevity-mushrooms-ergothioneines-remarkable-impact-on-lifespan-and-cognitive-enhancement) - Japanese scientists show that treating male mice with ergothioneine, a compound found in Lion's Mane in high concentrations, significantly extends lifespan
- [Scientists Engineer Peptide-Blood Gels that Successfully Regenerate Bone](https://www.nmn.com/news/scientists-engineer-peptide-blood-gels-that-regenerate-bone) - University of Nottingham researchers engineer peptide-blood gels that mimic natural healing, enhance bone regeneration, and reduce inflammation.
- [Could Stem Cells Cure Vision Loss? New Study Says Yes!](https://www.nmn.com/news/could-stem-cells-cure-vision-loss-new-study-says-yes) - Japanese researchers find that human stem cell-derived retinal sheets can repair macular holes in non-human primates.
- [Seragon Unveils Enlivien: Sleep & Longevity Optimizer](https://www.nmn.com/news/seragon-unveils-enlivien-sleep-longevity-optimizer) - Seragon Biosciences has launched a new sleep and longevity optimizer, Enlivien, which aims to mitigate the harmful cellular effects of sleep loss on the gut and nervous system.
- [How Innovative Therapies Are Tackling the Root Causes of Aging](https://www.nmn.com/news/how-innovative-therapies-are-tackling-the-root-causes-of-aging) - Scientists are performing research to find whether aging interventions targeting multiple hallmarks of aging, effective in animal models, also work in humans.
- [Breakthrough Aging Clock Reveals Anti-Aging Drugs for the Brain](https://www.nmn.com/news/breakthrough-aging-clock-reveals-anti-aging-drugs-for-the-brain) - Researchers used a brain aging clock based on human brain tissue gene activity changes during aging to identify potential brain-rejuvenating compounds.
- [New Harvard-Mayo-Cedars-Sinai Joint Study Confirms Safety of Anti-Aging Senolytic Treatment](https://www.nmn.com/news/new-harvard-study-anti-aging-senolytics-are-safe-for-seniors-with-memory-loss) - Highlights Senolytics are an exciting anti-aging technology that may potentially treat multiple age-related diseases, including dementia. The senolytics DQ were safe and led to no serious side effects in individuals at risk for Alzheimer’s. DQ reduced an inflammatory marker that was correlated with improved memory. Alzheimer's disease (AD) robs individuals not only of their memories Senolytics are safe for older adults at risk for Alzheimer's.
- [Flower Extract Slows Cellular Aging & Improves Life Quality, New Study Shows](https://www.nmn.com/news/flower-extract-slows-cellular-aging-improves-life-quality-new-study-shows) - Highlights Monarda didyma L. extract decreases telomere shortening in human skin cells, indicating improved cellular aging. The extract prevents telomere shortening and biological aging in middle-aged adults. The extract also improved quality of life scores in the physical health domain. Recent research, including a compelling study published in Geroscience, is shedding light on how the Monarda didyma L. extract prevents biological aging and telomere shortening in middle-aged adults.
- [Scientists Engineer Breakthrough Injection That May Reverse Alzheimer’s Disease](https://www.nmn.com/news/scientists-discover-breakthrough-injection-that-may-reverse-alzheimers-disease) - A single injection with breakthrough nanoparticles cleared nearly half of the toxic plaques associated with Alzheimer’s disease in mice modeling Alzheimer’s.
- [Predicting Age-Related Diseases with the Apple Watch: New Study Confirms Reliability](https://www.nmn.com/news/predicting-age-related-diseases-with-the-apple-watch-new-study-confirms-reliability) - Highlights Using artificial intelligence to analyze data from Apple Watch users, researchers predicted each user’s age with an error of less than 3 years. Predicted biological age was used to determine the probability of age-related diseases, such as diabetes and heart disease. The watch was also used to show how biological age changes in response Apple Watch can be used to determine biological age and predict disease.
- [The Longest-Lived People in World History: Record-Holders of Human Longevity](https://www.nmn.com/news/the-longest-lived-people-in-world-history-record-holders-of-human-longevity) - Women make up the world’s top 10 longest-lived people, likely due to having two X chromosomes and a lower propensity to engage in risky behavior compared to men.
- [Hyaluronan Supplement Prevents Frailty with Advanced Age, Suggests New Study](https://www.nmn.com/news/hyaluronan-supplement-prevents-frailty-with-advanced-age-suggests-new-study) - A new study provides data suggesting that high-molecular-weight hyaluronan supplementation prevents frailty with advanced age in mice.
- [Peter Attia Hosts Longevity Roundtable on Strength, Protein, and Training for Healthy Aging](https://www.nmn.com/news/peter-attia-hosts-longevity-roundtable-on-strength-protein-and-training-for-healthy-aging) - Peter Attia hosts a longevity roundtable to explore strength, muscle, and protein strategies for aging well with Gabrielle Lyon, Mike Boyle, and Jeff Cavaliere.
- [One Week of Melatonin Supplementation Prevents Age-Related Memory Decline](https://www.nmn.com/news/one-week-of-melatonin-supplementation-prevents-age-related-memory-decline) - Highlights One week of melatonin supplementation prevents age-related memory decline in mice. Melatonin reduces damage to the protective barrier that surrounds the central nervous system. Supplementation with melatonin elevates the longevity-associated molecule AMPK, which activates a molecule that regulates memory formation called CRTC1. Aging impairs our ability to remember particular experiences, whether it be of Melatonin improves the memory of middle-aged mice.
- [Partial Brain Reprogramming: FDA Greenlights Path to First Human Trial](https://www.nmn.com/news/partial-brain-reprogramming-fda-greenlights-first-human-trial) - Highlights Partial reprogramming rejuvenates cells by reverting them to an earlier stage of development. Partial reprogramming has been used to prolong the lifespan and improve the cognition of mice. YouthBio will now prepare for testing partial reprogramming on Alzheimer’s patients. YouthBio Therapeutics, a biotech company based in Seattle, recently announced the FDA’s greenlighting of a The FDA greenlights a path towards testing partial brain reprogramming on humans.
- [What Is the Best Age to Start Aging Interventions?](https://www.nmn.com/news/what-is-the-best-age-to-start-aging-interventions) - Highlights Across mammalian species, a slower pace of development has been associated with a longer lifespan. This phenomenon suggests that modulating aging pathways during developmental stages of life with aging interventions could help maximize lifespan. Corroborating this notion, studies have shown that metformin extends the lifespan of male mice if started during early life but
- [Creatine: A Potential Aid for Muscle Health in Alzheimer's](https://www.nmn.com/news/creatine-a-potential-aid-for-muscle-health-in-alzheimers) - Highlights Creatine increases grip strength but not leg strength in AD patients. Creatine also increases thigh muscle size while reducing thigh fat in AD patients. Taking creatine could potentially contribute to the treatment of AD. AD is a progressive neurodegenerative disorder that not only affects cognitive function but also often leads to a decline in Creatine supplement improves grip strength and thigh muscle size in older adults.
- [Research Illuminates Brain Mechanism Involved in Age-Related Motivational Decline and How It Might Be Restored](https://www.nmn.com/news/research-illuminates-brain-mechanism-involved-in-age-related-motivational-decline-and-how-it-might-be-restored) - Researchers unveil new data suggesting that an age-related motivational decline stems from reduced levels of a protein called BDNF in the brains of mice.
- [Anti-Aging Supplement NMN Reverses Hair Thinning in Middle-Aged Adults](https://www.nmn.com/news/anti-aging-supplement-nmn-reverses-hair-thinning-in-middle-aged-adults) - Highlights NMN supplementation reverses hair thinning. NMN increases hair elongation but decreases hair count. NMN improves subjective perception of hair quality. Aging, stress, and poor nutrition can lead to hair thinning, which can lower perceived quality of life for many individuals. Considering the potentially broad anti-aging benefits of NAD+ (nicotinamide adenine dinucleotide) precursors like NMN, NMN reverses hair thinning in middle-aged women.
- [FDA Reverses Course and Dubs NMN Lawful in Dietary Supplements](https://www.nmn.com/news/fda-dubs-nmn-lawful-in-dietary-supplements) - In a reverse course action, the FDA has declared that NMN is lawful for use in dietary supplements.
- [How Did the World's Oldest Person, María Branyas Morera, Live So Long?](https://www.nmn.com/news/how-did-the-worlds-oldest-person-live-so-long) - María Branyas Morera lived to 117, and a study of her medical profile suggests she had some genetic predispositions for longevity, high levels of beneficial gut microbes, and a slowed pace of aging.
- [Human Trial Results: Plant-Based Phytosterols Improve Age-Related Metabolic Disorder](https://www.nmn.com/news/latest-research-plant-derived-phytosterols-shown-to-improve-age-related-metabolic-disorder) - A review of studies shows that plant-derived phytosterol supplementation counteracts aspects of metabolic syndrome, such as high blood triglycerides.
- [Aubrey de Grey on the Future of Longevity and Aging Research](https://www.nmn.com/news/aubrey-de-grey-on-the-future-of-longevity-and-aging-research) - Aging expert Aubrey de Grey discusses additively extending mouse lifespan with multiple aging interventions at the Longevity Summit Dublin 2025.
- [Longevity Expert Debunks 4 Myths About Aging Science](https://www.nmn.com/news/longevity-expert-debunks-10-myths-about-aging-science) - Dr. Kaeberlein debunks the following myths: We can directly measure biological age. Supplements are a core part of improving health and longevity. It’s too late to start worrying about longevity. Aging research is well-funded. The internet and social media have facilitated the widespread dissemination of misinformation. The ever-evolving landscape of health and longevity is by Myths about aging debunked by top expert.
- [Life Biosciences, Co-founded by Harvard’s David Sinclair, Reveals Promising Data on Age-Reversing Drug Candidates](https://www.nmn.com/news/life-biosciences-co-founded-by-harvards-david-sinclair-reveals-promising-data-on-age-reversing-drug-candidates) - Life Biosciences has unveiled preclinical data showing that its partial epigenetic reprogramming drug candidates improve liver function and neuronal regeneration.
- [Creatine for Sleep Deprivation: New Study Shows Single-Dose Benefits](https://www.nmn.com/news/creatine-for-sleep-deprivation-new-study-shows-single-dose-benefits) - Highlights Creatine counteracts memory loss and processing speed in people who have been sleep deprived. Creatine also counteracts some of the negative metabolic alterations associated with sleep deprivation. We've all been there: a late night, an early start, and the ability to think and remember dwindles. Sleep deprivation is a common challenge in our modern Creatine counteracts sleep deprivation-induced memory loss.
- [New Study Shows Senolytic Supplements Prevent Hair Graying](https://www.nmn.com/news/new-study-shows-senolytic-supplements-prevent-hair-graying) - Highlights A hormone called insulin growth factor increases with age in the skin and is associated with accelerated aging. In mice that model skin aging via high insulin growth factor levels, hair graying is prevented by activating longevity-associated sirtuins, senolytics, or dietary restriction. Cellular senescence plays a key role in the progression of aging and Senolytics prevent hair graying in mice.
- [Longevity Supplement Ergothioneine Improves Sleep in New Study from Japan](https://www.nmn.com/news/anti-aging-supplement-ergothineine-improves-sleep-in-new-study-from-japan) - Highlights Ergothioneine supplementation improves both subjective and objective measures of sleep. Ergothioneine supplementation increases anti-inflammatory and antioxidant molecules. Adequate sleep is a fundamental aspect of healthy aging, as good sleep is associated with a 48% lower risk of all-cause mortality. Quality sleep improves cardiovascular health, memory consolidation, reproductive health, immunity, and mental health. On the Ergothioneine improves sleep in humans.
- [Can Nicotine Combat Aging? Study Links It to Higher NAD+ and Better Motor Function](https://www.nmn.com/news/can-nicotine-combat-aging-study-links-it-to-higher-nad-and-better-motor-function) - Researchers unveil data suggesting that long-term oral nicotine consumption preserves motor function, raises NAD+, and lowers biological age in older male mice.
- [New Johns Hopkins Study: Senescence Links Dementia to Osteoporosis](https://www.nmn.com/news/new-john-hopkins-study-senescence-links-dementia-to-osteoporosis) - Highlights Senescent fat cells in bone marrow secrete a molecule called SAP that plays a role in the formation of Alzheimer’s plaques. Removing senescent cells with senolytics prevents age-related bone loss. Considering previous studies, senolytics can potentially target both Alzheimer’s dementia and osteoporosis simultaneously. For decades, Alzheimer's disease (AD) has primarily been viewed as a Senolytics prevent bone loss and prevent the accumulation of amyloid-beta protein.
- [HIV Drug May Counteract Age-Related Muscle Loss, New Study Finds](https://www.nmn.com/news/hiv-drug-may-counteract-age-related-muscle-loss-new-study-finds) - The HIV drug maraviroc increases muscle size and running capacity in aged mice, supporting its potential to work against an age-related decline in muscle function.
- [New Human Study Finds Vitamin E Supplement May Counteract Signs of Aging](https://www.nmn.com/news/new-study-finds-vitamin-e-supplement-may-reduce-signs-of-aging) - Highlights Aged participants who took tocotrienol daily for six months scored significantly better on assessments of quality of life. Tocotrienol also increased antioxidant enzymes as well as telomerase (an enzyme that extends the protective caps of DNA at the ends of chromosomes). While vitamin supplements are not a magical solution to reverse aging, some may
- [NMN-Loaded Vesicles Shown to Delay Skin Aging in New Study](https://www.nmn.com/news/nmn-loaded-vesicles-shown-to-delay-skin-aging-in-new-study) - Treating a skin aging mouse model with NMN-loaded umbilical cord vesicles delays skin aging, which may also confer whole-body rejuvenation effects.
- [Boost Your Longevity: Dr. William Li's Favorite Foods for Stem Cell Activation](https://www.nmn.com/news/boost-your-longevity-dr-william-lis-favorite-foods-for-stem-cell-activation) - Highlights Dark chocolate mobilizes stem cellsfrom places like the bone marrow into the bloodstream. Goji berries protect and mobilizestem cells and are believed to help preserve vision health. Red bell peppers are a source ofcompounds that contribute to stem cell mobilization and are believed to helpvision health. Tea (black and green) revitalizes and mobilizes stem
- [Longevity Supplements: New Research Reveals What the Longest-Lived People Take](https://www.nmn.com/news/longevity-supplements-new-research-reveals-what-the-longest-lived-people-take) - According to a survey of nearly 3,000 centenarians, the most common supplements taken are Calcium Protein Multivitamin Iron Zinc Vitamin A/D DHA Fish oil Centenarians maintain a surprising degree of functional independence and often exhibit a delayed onset of age-related diseases. For scientists, this makes centenarians living blueprints for successful aging. Understanding the factors that The supplements that centenarians take.
- [New Research: Apigenin Prevents Muscle Shrinkage from Aging & Weight Gain](https://www.nmn.com/news/new-research-apigenin-prevents-muscle-shrinkage-from-aging-weight-gain) - Highlights Apigenin prevents calf muscle shrinkage induced by a high-calorie diet. Apigenin does not prevent weight gain induced by a high-calorie diet. Apigenin elevates a protein associated with anabolic (muscle-building) processes. Scientists are tirelessly searching for ways to mitigate the health challenges that accompany aging and obesity. One such challenge is sarcopenia, the age-related loss
- [Epigenetic Aging Clocks Compared: Which One Predicts Mortality Best?](https://www.nmn.com/news/epigenetic-aging-clocks-compared-which-one-predicts-mortality-best) - National Institute on Aging scientists conducted a large-scale statistical analysis suggesting that the GrimAge epigenetic clock works best to predict mortality.
- [A Drug that Removes Senescent Cells Extends Life, New Japanese Study Reveals](https://www.nmn.com/news/a-drug-that-removes-senescent-cells-extends-life-new-japanese-study-reveals) - Highlights Canagliflozin reduces senescence in the fat tissue of obese mice. Canagliflozin protects against heart disease in a mouse model for atherosclerosis. Canagliflozin prolongs the life of prematurely aged mice and improves the strength of naturally aged mice. The latest research suggests that senescent cells accumulate in our body because our immune system weakens with Canagliflozin removes senescent cells and delays aging.
- [Jim O’Neill, Robert F. Kennedy Jr.’s New Right-Hand Man, Wants to Extend Human Lifespan](https://www.nmn.com/news/jim-oneill-robert-f-kennedy-jr-s-new-right-hand-man-in-trumps-health-agency-wants-to-extend-human-lifespan) - Highlights As Robert F. Kennedy Jr.’s new right-hand man, Jim O’Neill may spur publicity and funding for longevity science. Amid funding cuts for biomedical research under the current presidential administration, it remains unclear what gains longevity research will be able to make under O’Neill’s influence on the HHS. On June 9, Jim O’Neill was sworn
- [NMN Reduces Heart Attack Damage by Activating Anti-Inflammatory Cells, New Study Shows](https://www.nmn.com/news/nmn-reduces-heart-attack-damage-by-activating-anti-inflammatory-cells-new-study-shows) - Highlights NMN induces the secretion of a protective protein called U2AF1 from immune cells that prevents heart damage. U2AF1 supports the survival of mice after a heart attack. Concentrations of U2AF1 are lower in heart attack patients. Myocardial infarction (MI), or heart attack, occurs when a part of the heart dies due to a lack NMN reduces heart attack damage by enhancing immune cells.
- [Unlock Better Balance, Strength & Less Inflammation with Taurine: Yale Research](https://www.nmn.com/news/unlock-better-balance-strength-less-inflammation-with-taurine-yale-research) - Highlights Taurine improves the strength, balance, and coordination of older mice while reducing inflammation. Taurine is elevated in calorically restricted and aged humans. Taurine reduces inflammation by inhibiting a multi-protein structure called an inflammasome. Taurine, often found in energy drinks, is a non-essential amino acid that functions to maintain fluid levels within cells. Recently shown Taurine reduces inflammation in older mice, leading to improved strength.
- [NAC Boosts Vitamin D Against Senescent Cells, New Study Reveals](https://www.nmn.com/news/potent-antioxidant-enhances-vitamin-d-against-age-promoting-senescent-cells-in-humans-new-study-shows) - Highlights Senescent cells are an age-accelerating consequence of immune system aging. Vitamin D and NAC reduce senescent cells in older adults, and NAC appears to enhance vitamin D’s effects. A profound transformation occurs within our bodies as we age, particularly within our immune system. This age-related alteration in immune function, known as immunosenescence, is not Combining a potent antioxidant with vitamin D reduces senescent cells and combats immune system aging.
- [Combining Two FDA-Approved Drugs Prolongs Life by Over 30%](https://www.nmn.com/news/combining-two-fda-approved-drugs-prolongs-life-by-over-33) - Highlights: In addition to prolonging median lifespan, the rapamycin and trametinib combo prolongs maximum lifespan by 32% for females and 26% for males. While the combo improved several aspects of health, it also led to side effects such as testicular degeneration and fatty liver. In these latter stages of modern human civilization, modern medicine has allowed
- [79-Year-Old Pioneering Nutritional Biochemist Shares Secrets Behind His Astonishing Medical Profile](https://www.nmn.com/news/79-year-old-pioneering-nutritional-biochemist-shares-secrets-behind-his-astonishing-medical-profile) - Dr. Jeff Bland, a 79-year-old nutritional biochemist, shares how to possibly rejuvenate the immune system with plant-derived compounds and other dietary choices as we age.
- [NMN Supplement Enhances Effect of Fasting on Physical Performance, New Study Shows](https://www.nmn.com/news/nmn-supplement-enhances-effect-of-time-restricted-fasting-on-physical-performance-new-study-shows) - Highlights NMN enhances the effect of time-restricted fasting on body composition, muscle NAD+ levels, and muscle mitochondrial health. Time-restricted fasting improves endurance and gut microbiome health only when combined with NMN. A recent study published in Nutrients explores a powerful new health strategy: combining time-restricted fasting (TF) with the NAD+ precursor NMN to improve energy NMN enhances the effect of time-restricted feeding.
- [US State Passes Bill Enabling Access to Unproven Longevity-Related Therapies](https://www.nmn.com/news/us-state-passes-bill-enabling-access-to-unproven-longevity-related-therapies) - Montana has passed a new bill that could make the state a hotbed for longevity clinics that administer drugs and therapies not yet approved by the FDA.
- [Recharging the Brain: How a Cellular Energy Boost Could Combat Neurodegenerative Diseases](https://www.nmn.com/news/recharging-the-brain-how-a-cellular-energy-boost-could-combat-neurodegenerative-diseases) - Highlights • Inflammation impairs mitochondria and mitophagy, worsening brain cell damage. • Supplementing with NMN restores cellular energy but may overstimulate harmful pathways. • Combining NMN with a PARP1 inhibitor restores mitochondrial health and supports brain resilience. Bringing the brain's energy and immune systems back into balance is a promising new way for scientists to
- [Bryan Johnson's Anti-Aging Stack: 2025 Protocol](https://www.nmn.com/news/the-anti-aging-therapeutics-bryan-johnson-takes-in-2025) - According to his post on X.com, Johnson’s stack is as follows: Acarbose: 200 mg/day Tadalafil: 2.5 mg/day Candesartan: 8 mg/day Jardiance: 10 mg/day Repatha: 140 mg/biweek Thyroid Extract: 60 mg/day Levothyroxine: 100 µg/day Minoxidil: 3.75 mg/day Capitalist and longevity poster-child Bryan Johnson is known for spending millions of dollars on improving his health and longevity. Bryan Johnson lists his longevity therapeutics.
- [At Age 115, the World’s Oldest Person Shares Her Longevity Secrets](https://www.nmn.com/news/at-age-115-the-worlds-oldest-person-shares-her-longevity-secrets) - Highlights On Wednesday, April 30, 2025, Ethel Caterham became the world’s oldest person following the death of 116-year-old Brazilian nun Inah Canabarro Lucas. Among some of Ethel Caterham’s longevity secrets, she says to say yes to every opportunity, and she approaches every circumstance with a positive mindset. At age 115, British woman Ethel Caterham became
- [The Sirtuin Secret: New Study Shows How NMN Helps These Longevity Enzymes Combat Aging](https://www.nmn.com/news/the-sirtuin-secret-new-study-shows-how-nmn-helps-these-longevity-enzymes-combat-aging) - Highlights NMN reduces brain inflammation and improves memory by activating sirtuins. NMN improves gut barrier integrity and protective lining by activating sirtuins. NMN-activated sirtuins reduce underlying biological drivers of aging, including inflammation and senescent cells. In the quest to understand and potentially slow the aging process, scientists have increasingly focused on a family of enzymes NMN mitigates brain and gut aging by activating sirtuin enzymes.
- [How to Foster Gut Bacteria Associated with Living Over 100 Years](https://www.nmn.com/news/dietary-habits-to-foster-gut-bacteria-associated-with-living-over-100) - Dr. William Li shares how eating fermented foods like yogurt and fiber-rich foods like nuts may aid the growth of beneficial gut bacteria for longevity.
- [MetroBiotech, Co-Founded by Harvard’s David Sinclair, Launches Human Trial of New NAD+ Booster MIB-725](https://www.nmn.com/news/metrobiotech-co-founded-by-harvards-david-sinclair-announces-human-trials-of-new-nad-booster) - MetroBiotech has begun testing the NAD+-elevating drug MIB-725’s safety, metabolism, and ability to increase circulating NAD+.
- [Seaweed Molecule Fucoidan Prolongs Life and Benefits Healthy Aging, New Study Shows ](https://www.nmn.com/news/seaweed-molecule-fucoidan-prolongs-life-and-benefits-healthy-aging-new-study-shows) - Highlights Oral supplementation of fucoidan prolongs the lifespan of male mice by 13%. Fucoidan also reverses biological aging, as measured by a genetic clock technique. Fucoidan deters the gradual age-related decline of health. Numerous studies suggest that enzymes called sirtuins modulate aging at the cellular level. As such, scientists from the University of Rochester in Seaweed molecule extends the lifespan of mice.
- [Blue Zone Diet Secrets: What Compounds Keep You Young](https://www.nmn.com/news/blue-zone-diet-secrets-what-compounds-keep-you-young) - The five longevity Blue Zones, scattered around the world, share one common feature—a high intake of plant-derived compounds called polyphenols.
- [Latest Study Suggests a Mix of Compounds That Includes NMN Enhances Immunity Against Cancer](https://www.nmn.com/news/latest-study-suggests-a-mix-of-compounds-that-includes-nmn-enhances-immunity-against-cancer) - A study suggests that a combination of aging intervention compounds, including NMN, enhances immunity against cancer cells.
- [New Sirtuin Activator Against Age-Related Diseases Hitting Clinical Trials](https://www.nmn.com/news/new-sirtuin-activator-against-age-related-diseases-hitting-clinical-trials) - Highlights Scientists have engineered molecules capable of nearly doubling the activity of sirtuin 3, a longevity enzyme once thought undruggable. One of the new sirtuin 3 activators is more effective than NMN and may help bring mitochondrial health to youthful states. Clinical trials for the new sirtuin activators are set to begin in 2025. Without enzymes, we Sirtuin 3 activator to enter clinical trials.
- [Age-Reversal Tech Increases Pregnancy Rates 3-Fold, According to New Study](https://www.nmn.com/news/new-gene-therapy-that-reprograms-brain-cells-delays-female-infertility) - Highlights Reprogramming gene therapy increases pregnancy rates from 8.3% to 25%. Reprogramming gene therapy does not increase the number of pups born, but improves hormone cycles. The “age center of the brain” may modulate the onset of infertility by regulating the release of hormones. In the recent explosion of anti-aging research, an intervention technology capable of potentially Cellular reprogramming improves fertility.
- [New Study Explains How Ozempic Could Extend Life](https://www.nmn.com/news/new-nature-study-unveils-the-most-age-sensitive-brain-cells-suggesting-how-caloric-restriction-extends-life) - Highlights: The brain cells most vulnerable to aging are located in a structure called the hypothalamus and many surround the third ventricle, which stores spinal fluid. The weight loss drug Ozempic can target some of the hypothalamus cells vulnerable to aging, which could lower brain inflammation. Caloric restriction may prolong lifespan by protecting against the brain cells Brain cells involved in appetite are the most vulnerable to aging.
- [Retro Biosciences CEO Breaks Down Three Newly-Developed Aging Interventions](https://www.nmn.com/news/retro-biosciences-ceo-breaks-down-three-newly-developed-aging-interventions) - Retro Biosciences CEO Joe Betts-LaCroix discusses newly developed aging intervention strategies, one of which rejuvenates older cells and two others that replace older cells with younger ones.
- [Longevity Secrets from the World’s Oldest Person, María Branyas](https://www.nmn.com/news/longevity-secrets-from-the-worlds-oldest-person-maria-branyas) - 117-year-old María Branyas Morera attributed her longevity to strong family ties, positivity, avoiding toxic people, practicing moderation in her diet, and eating yogurt daily.
- [Ozempic and NMN Combo Could Boost Anti-Aging Effects by Activating Sirtuins](https://www.nmn.com/news/ozempic-and-nmn-combo-could-boost-anti-aging-effects-by-activating-sirtuins) - Highlights Sirtuins are enzymes fueled by NAD+ (nicotinamide adenine dinucleotide), associated with advantageously modulating aging. The GLP-1 receptor agonist drug liraglutide was shown to reduce inflammation and improve bone health via sirtuin 1, the most well-studied sirtuin. Combining NAD+ boosters with sirtuin activators could provide additive and synergetic effects. The weight loss drug Ozempic has been shown Liraglutide improves bone health by activating sirtuins.
- [The Longevity Clinics Owned by Peter Attia and Other Prominent Figures](https://www.nmn.com/news/the-longevity-clinics-owned-by-peter-attia-and-other-prominent-figures) - Highlights Coinciding with the purported golden age of aging research, big-name investors have started longevity-focused clinics attempting to help clients live longer.Some of these clinics include Peter Attia’s Biograph, Matt Kaeberlein’s Optispan, and J. Craig Venter’s Human Longevity. We are currently in the midst of the golden age of longevity research. Rising interest, especially among
- [The US Government's $500 Billion Gamble On AI Cures for Aging](https://www.nmn.com/news/americas-ai-advancing-stargate-project-aims-to-accelerate-breakthrough-cures-for-age-related-diseases) - The Stargate Project, proposed by President Trump on his first day in office, aims to drastically expand AI infrastructure and cure age-related diseases.
- [Ginkgo Biloba Molecule Prolongs Life by Targeting Senescent Cells, New Study Shows](https://www.nmn.com/news/ginkgo-biloba-molecule-prolongs-life-by-targeting-senescent-cells-new-study-shows) - Highlights Ginkgolide B prolongs the lifespan of mice by 8.5%. Ginkgolide B supplementation enhances strength and physical performance. Ginkgolide B reduces fat mass and increases lean mass. Is it worth living a long life diminished by chronic disease? Studies have shown that anti-aging compounds can prolong the lifespan of worms, flies, and mice, but at what expense? Ginkgo biloba compound prolongs life.
- [NMNH Raises NAD+ Substantially More than NMN](https://www.nmn.com/news/nmnh-substantially-raises-nad-levels-more-than-nmn) - Highlights Reduced nicotinamide mononucleotide (NMNH) substantially increases blood nicotinamide adenine dinucleotide (NAD+) in a sustained manner compared to nicotinamide mononucleotide (NMN) in mice.Tissues where NMN has not been shown to increase NAD+, such as muscle, the heart, and the brain, show about 20% to 30% more NAD+ with NMNH.Despite these promising preclinical study findings, there
- [New NAD World 3.0 Theory Emphasizes NMN’s Importance In Aging](https://www.nmn.com/news/new-nad-world-3-0-theory-emphasizes-nmns-importance-in-aging) - Washington University’s Shin-Ichiro Imai explains how an NMN cell transporter and vesicles containing an NMN synthesis enzyme play key roles in maintaining NAD+ levels, the decline of which is tied to aging.
- [New Harvard Study Shows NMN Supplement Enhances Blood Vessel Formation](https://www.nmn.com/news/new-harvard-study-shows-nmn-supplement-enhances-blood-vessel-formation) - Highlights Aging impairs the formation of new blood vessels. NMN counteracts age-related impairments in blood vessel formation. Combining NMN with Lion’s Mane mushrooms could have additive effects. There are arguments over whether the deterioration of our blood vessels, where blood courses through our body, is the cause of aging. If so, preventing or reversing the deterioration of NMN supports blood vessel health.
- [New Research Reveals Sleep Medication Could Make Your Brain Age Faster](https://www.nmn.com/news/new-research-reveals-common-drug-could-make-your-brain-age-faster) - Highlights: For the first time, researchers were able to study the brain physiology of mice during natural sleep. Zolpidem, an FDA-approved drug that goes under brand names like Ambien, Edluar, and Zolpimist, disrupts natural sleep physiology, potentially increasing the risk of neurodegeneration. The number of hours we lie in bed unconscious may not be the best Ambien contributes to dementia by disrupting brain physiology.
- [Modulating mTOR to Slow Aging with Fasting, Quercetin, Curcumin, and Rapamycin](https://www.nmn.com/news/modulating-mtor-to-slow-aging-with-fasting-quercetin-curcumin-and-rapamycin) - In a YouTube segment, naturopathic physician Dr. Paul Anderson describes why some people target mTOR inhibition to promote longevity.
- [New Hair Regrowth Agent Isoquercitrin Targets Hallmarks of Aging](https://www.nmn.com/news/potential-hair-regrowth-agent-targets-hallmarks-of-aging-new-study-shows) - Highlights: Isoquercitrin stimulates hair growth by inhibiting the nutrient-sensing molecule mTOR and promoting cellular waste removal in young rats. Isoquercitrin also stimulates hair growth in middle-aged rats. What if age-related hair loss could be reversed? This is what researchers from Zhejiang University in China sought to discover by examining isoquercitrin, a compound found in tea leaves, Isoquercitrin accelerates hair regrowth.
- [The Lowdown on Seragon’s RESTORIN Aging Optimizer](https://www.nmn.com/news/the-lowdown-on-seragons-anti-aging-optimizer) - The anti-aging optimizer RESTORIN contains mTOR inhibitors, autophagy and mitophagy activators, senolytics, and NAD+ boosters.
- [Are Microplastics the Silent Killer? Here’s What You Need to Know](https://www.nmn.com/news/are-microplastics-the-silent-killer-heres-what-you-need-to-know) - The average person ingests or inhales up to 120,000 microplastic particles annually, which accumulate in vital organs and may contribute to accelerated aging.
- [Cellular Reprogramming Counteracts Accelerated Brain Aging](https://www.nmn.com/news/new-anti-aging-technology-counteracts-accelerated-brain-aging) - Highlights: Cellular reprogramming technology reverts cells to an earlier stage of development, essentially making them younger. Cellular reprogramming increases the brain size of mice during development leading to improved brain function. Cellular reprogramming gene therapy mitigates symptoms of Alzheimer’s disease in a mouse model. An international team of scientists from Germany, Spain, France, Taiwan, and the United Cellular reprogramming technology mitigates Alzheimer's disease.
- [Statins Reduce the Risk of 21 Cancers](https://www.nmn.com/news/fda-approved-drugs-reduce-the-risk-of-21-cancers) - Highlights: Lipid-lowering drugs like statins reduce the risk of 21 types of cancers, including lung, brain, and reproductive system cancers. In addition to changing one’s lifestyle, lipid-lowering drugs may act as a preventative measure against cancer. Everyone hates cancer and now scientists are coming closer to preventing it. By analyzing over 380,000 individuals from the UK Statins lessen the risk of 21 cancers.
- [NMN Suppresses the Progression of Hearing Loss, New Research from Japan Shows](https://www.nmn.com/news/nmn-suppresses-the-progression-of-hearing-loss-new-research-from-japan-show) - Highlights: Compared to young mice, older mice exhibit hearing loss. NMN prevents this age-related deficits in hearing. According to John Hopkins, mild hearing loss doubles the risk of dementia, moderate loss triples the risk, and severe hearing loss increases the risk fivefold. While hearing aids can slow cognitive decline, they can be expensive, amplify background noises, NMN prevents age-related hearing loss.
- [Is Taking NMN Better Than Eating Broccoli?](https://www.nmn.com/news/is-taking-nmn-better-than-eating-broccoli) - Highlights: NMN and sulforaphene improve aspects of skin aging, including raising levels of hyaluronic acid, a substance that decreases with aging and contributes to wrinkles. NMN and sulforaphene counteract biological drivers of skin aging: inflammation and oxidative stress. Broccoli and other leafy greens are nutrient-rich foods associated with reducing all-cause mortality, cardiovascular disease, and cancer. For NMN and broccoli compound counteract skin aging.
- [NMN and CoQ10 Can Minimize Irregular Heartbeats Following a Heart Attack](https://www.nmn.com/news/nmn-and-coq10-can-minimize-irregular-heartbeats-following-a-heart-attack) - Highlights The combination of NMN and CoQ10 decreased the severity and frequency of irregular heartbeats after a heart attack in aged rats.The NMN and CoQ10 combination also improved levels of several indicators of heart stress and damage. New research has pointed to a simple way to get the heart to maintain a healthy and normal
- [Neural Stem Cell Transplants Show Safety and Potential in Breakthrough Phase 1 Spinal Cord Injury Trial](https://www.nmn.com/news/neural-stem-cell-transplants-show-safety-and-potential-in-breakthrough-phase-1-spinal-cord-injury-trial) - Neural stem cell transplants show long-term safety, reduce chronic pain, and improve motor control in spinal cord injury patients.
- [New Epigenetic Clocks Advance Age Assessment Precision](https://www.nmn.com/news/new-epigenetic-clocks-advance-age-assessment-precision) - A cell-type resolution-based aging clock that advances the precision of aging assessments may help uncover effective aging intervention therapeutics.
- [Probiotics Reverse Aging When Combined with Vitamin D, New Research Shows](https://www.nmn.com/news/probiotics-reverse-aging-when-combined-with-vitamin-d-new-research-shows) - Highlights: Three probiotic strains combined with vitamin D reduce the biological age of men and women by an average of 11 years. The probiotic and vitamin D combo also improves immune system function and deters two important biological drivers of aging. The composition of our gut bacteria plays a major role in how we age and Probiotics and vitamin D reverse aging.
- [New Study: A Bile Acid May Mimic Rejuvenating Effects of Calorie Restriction](https://www.nmn.com/news/new-study-a-bile-acid-may-mimic-rejuvenating-effects-of-calorie-restriction) - Highlights Through the analysis of metabolite concentrations affected by calorie restriction, scientists identified lithocholic acid (LCA), which activates a pathway that works against aging.When administered to aged mice fed a standard diet, lithocholic acid mimicked calorie restriction by alleviating insulin resistance and improving physical function. Calorie restriction (CR), where daily caloric intake is reduced by
- [Governmental Initiative Aims to Extend Americans’ Healthy Lifespan](https://www.nmn.com/news/governmental-initiative-aims-to-extend-americans-healthy-lifespan) - A new initiative associated with the US Department of Health and Human Services (HHS) aims to prolong the years without age-related disease for Americans.
- [New Research Uncovers Link Between Antibody Buildup and Aging](https://www.nmn.com/news/new-research-uncovers-link-between-antibody-buildup-and-aging) - New research uncovers an age-associated buildup of antibodies across tissues in mice and humans, and reducing antibody levels mitigates signs of aging in mice.
- [Can NMN End Your Struggle with Dry Mouth?](https://www.nmn.com/news/can-nmn-end-your-struggle-with-dry-mouth) - NMN treatment restores salivation against age-related dry mouth in old mice.
- [Age-Accelerating Poison in the Air and Food: Microplastics](https://www.nmn.com/news/are-we-breathing-in-and-ingesting-aging-the-microplastics-connection) - Microplastics exposure is associated with increased levels of protein markers associated with aging in fat tissues of mice.
- [NMN Inhibits the Onset of Liver Fibrosis](https://www.nmn.com/news/nmn-inhibits-the-onset-of-liver-fibrosis) - When our livers get injured, whether from chronic alcohol use or the buildup of cellular stress in the form of damaging molecules called reactive oxygen species, it can cause scarring, known as fibrosis. This excessive scarring can lead to diseases like liver cancer and cirrhosis and, currently, no therapeutic options to prevent it exist. Deng
- [Australian Study Shows NMN Delivers Stronger Bones](https://www.nmn.com/news/australian-study-shows-nmn-opposes-age-related-bone-disease) - Highlights: NMN reduces senescent age-accelerating cells in human bone cell cultures. Treating human bone cells with NMN promotes bone formation. Osteoporotic mice injected with NMN display increased bone volume. Though our bones become weak and prone to fracture with age, current therapies only modestly increase bone mineral density. This issue is largely due to the underlying causes
- [NMN Demonstrates Potential Efficacy in a Glaucoma Model](https://www.nmn.com/news/japanese-study-indicates-nmn-prevents-pressure-induced-eye-damage) - Highlights NMN treatment blocks eyeball pressure-induced tissue damage in mice. NMN prevents injury to the eye’s retina – the surface on which light is projected for us to perceive the external world – by reducing inflammation. NMN rescues mouse retinal cells from death by countering oxidative stress – where cells don’t sufficiently detoxify harmful, oxygen-containing
- [Study Finds Protecting Skin Cells from UV Damage Depends on NMN Synthesis](https://www.nmn.com/news/protecting-skin-cells-uv-damage-nmn-synthesis) - Highlights · UV radiation triggers the enzymes NAMPT and PARP — which produce and consume NAD+, respectively — in a tug of war between cell survival and dysfunction. · Inhibiting NAMPT allows PARP to exhaust the NAD+ supply, which hinders the response from skin cells to UV damage and cell proliferation. ·
- [Study Shows that NAD+ Precursors Reverse Blood Vessel Dysfunction](https://www.nmn.com/news/nad-precursors-endothelial-inflammation-dysfunction) - Some nicotinamide adenine dinucleotide (NAD+) precursors have the potential to be vasoprotective — they can act to alleviate or prevent conditions or diseases that affect the blood vessels. Despite many studies on the benefits of two of these NAD+ precursors nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), the effects on the endothelium — the cells
- [NMN Lowers Blood Pressure in Patients with Hypertension: Latest Human Trial](https://www.nmn.com/news/nmn-lowers-blood-pressure-in-patients-with-hypertension-latest-human-trial) - Highlights Supplementing hypertension patients with 800 mg of oral NMN per day for six weeks significantly lowers their blood pressure.Hypertension patients display significantly lower blood cell NAD+ levels, and taking NMN increases their blood cell NAD+ levels by ~43%..Adults with hypertension have cells lining blood vessels — endothelial cells — with elevated concentrations of the
- [Study Indicates NMN Has Anti-Aging Potential for Kidneys](https://www.nmn.com/news/nmn-anti-aging-kidneys) - The world’s population of older adults continues to expand at an unprecedented pace. So, there is a need for a better understanding of aging processes to mitigate age-related diseases and disorders. But not all organs age at the same pace, so it’s important for scientists to characterize aging processes for each organ. Recently, Deng and
- [Silver Quantum Dots Enhance Liver Absorption and Therapeutic Effectiveness of NMN and Metformin](https://www.nmn.com/news/silver-quantum-dots-enhance-liver-absorption-therapeutic-effectiveness-nmn-metformin) - Highlights Attaching NMN and metformin to silver nanocrystals called quantum dots significantly enhances their uptake into liver cells.The quantum dot-bound NMN and metformin facilitate improved metabolic responses like blood glucose clearance at much lower drug doses. Nanomedicine is the application of nanotechnology – technology dealing with tiny dimensions of less than 100 nanometers – to
- [New Aging Clock Predicts NMN and Metformin Reduce Biological Age](https://www.nmn.com/news/new-aging-clock-predicts-nmn-and-metformin-reduce-biological-age) - Highlights Assessing gene activity by measuring messenger RNA (mRNA) transcript levels – transcriptomics – reveals differences in the aging rate between individuals. Slow-aging individuals exhibit blood immune cell levels indicative of less inflammation compared to fast-aging individuals. Treatment with nicotinamide mononucleotide (NMN) or Metformin reduces the predicted biological age. The world has a rapidly expanding
- [Latest Study: NMN Prevents Lung Injury from Exposure to Air Pollutants](https://www.nmn.com/news/latest-study-nmn-prevents-lung-injury-from-exposure-to-air-pollutants) - Highlights Nicotinamide adenine dinucleotide (NAD+) levels fall 39.86% in the lungs from air pollutant (particulate matter [PM]) exposure, likely inducing inflammation that precipitates lung injurySupplementing with nicotinamide mononucleotide (NMN) before and during PM exposure prevents damaging lung injury.Confirming NMN’s lung-preserving effects against inflammation, NMN supplementation cuts in half elevated inflammatory protein TNF-ɑ levels from PM
- [NMN Protects Egg Cells from Reproductive Toxins](https://www.nmn.com/news/nmn-protects-egg-cells-reproductive-toxins) - Highlights The common household and industrial solvent ethylene glycol butyl ether (EGBE) is a reproductive toxin that causes deterioration of mammalian egg cell (oocyte) quality.NMN protects oocyte quality from EGBE-induced deterioration. With every birth, we always hope for the emergence of a healthy child — “ten fingers and ten toes.” But some chemical substances interfere
- [NMN Reduces Inflammation and Defends Against Viruses: Japanese Study](https://www.nmn.com/news/nmn-reduces-inflammation-and-defends-against-viruses-japanese-scientists) - Highlights: NMN mitigates viral-mediated inflammation by preventing the elevation of mRNA for pro-inflammatory IL-6. NMN aids in defending cells against viruses by altering levels of mRNA for NAD+-dependent PARP9. Older folks are more susceptible to viral infection and exhibit higher mortality rates from viruses than younger folks. Such a conundrum may be exacerbated by deficiencies in
- [NMN Rejuvenates Bone Tissue Stem Cells](https://www.nmn.com/news/nmn-restores-stem-cells-bone-tissue-activating-nap1l2-protein) - Highlights The study suggests that NMN binds to the SIRT1 protein to activate genes for bone regeneration (osteogenesis).By stimulating osteogenesis, NMN may prevent the progression of osteoporosis. The breakdown and generation of new bone cells (osteogenesis) declines as people age. The disarray of bone regeneration stems from depleted stem cells in their original, youthful state
- [NMN May Improve the Brain-Associated Blood Vessel Cell Response to Stress](https://www.nmn.com/news/nmn-blood-brain-barrier-cell-response-stress) - Diabetes cases continue to rise sharply worldwide. These patients are more prone to stroke with a 50% greater risk of hemorrhagic stroke—blood vessels rupturing in the brain. This is thought to be caused by the dysfunction of brain-associated blood vessel cells—endothelial cells—during diabetes development. Although scientists understand that this breakdown is caused by inflammation and
- [New Study Shows NMN Rejuvenates Stem Cells and Mitochondria by Activating Longevity Protein](https://www.nmn.com/news/new-study-shows-nmn-rejuvenates-stem-cells-and-mitochondria-by-activating-longevity-protein) - Highlights NMN decreases cellular senescence - a dormant cell state that promotes aging - in stem cells and increases mitochondrial function.NMN’s effects on mitochondria and cellular senescence are governed by the increased activity of sirtuin 3 (Sirt3) - a guardian protein that helps regulate mitochondria. Stem cells have garnered extreme attention for their potential applications
- [NAD+ Precursors NMN and NR Suppress Hyper-Allergic Reactions](https://www.nmn.com/news/nad-precursors-nmn-and-nr-suppress-hyper-allergic-reactions) - Highlights NMN and NR mitigate severe allergic reactions termed anaphylaxis as measured by diminished body temperature drops and reduced ear swelling in mice. Both NAD+ precursors stifle the release of proinflammatory proteins from white blood cells called mast cells. Genetically deleting the protein Sirt6 mitigates the benefits of NMN and NR against anaphylaxis, indicating that
- [New Study Shows NMN May Prevent Reproductive Aging Caused by Chemical Found Ubiquitously in Consumer Products](https://www.nmn.com/news/study-suggests-chemical-found-ubiquitously-in-consumer-products-induces-features-of-reproductive-aging-which-nmn-prevents) - Highlights: Phthalate exposure induces features of aging in mouse oocytes, including reduced fertilization rate. NMN prevents disruptions in mitochondrial health induced by phthalates in mouse oocytes. Oocyte cell death and DNA damage induced by phthalate are prevented by NMN. The female reproductive system ages faster than any other system in the body, and the ability of oocytes
- [The Science Behind NMN](https://www.nmn.com/news/the-science-behind-nmm) - Highlights: NMN is made via various enzymes and is spread throughout the body within membrane-bound sacs secreted by fat cells. Animal studies have shown that NMN counteracts age-related diseases, in models of Alzheimer’s disease, diabetes, and stroke. Human studies have shown the benefits of NMN, including improved metabolism and enhanced physical activity. In an article published in
- [Scientists Show NMN Amends Eye Degeneration by Reducing Senescent Cells](https://www.nmn.com/news/nmn-eye-degeneration-senescent-cells) - Highlights: NMN eliminates senescent cells and drops DNA damage by 50% in a human cell model for macular degeneration — an age-related eye disease. Treatment with NMN restores retina structure while reducing senescence in a mouse model for macular degeneration. Our ability to visualize the fine details of our surroundings depends on a tiny patch of
- [Senolytics Alleviate COVID-Induced Brain Aging and Lifespan Shortening in New Study ](https://www.nmn.com/news/senolytics-alleviate-covid-induced-brain-aging-and-lifespan-shortening-in-new-study) - Highlights: In aged brains grown from human cells, the senolytics navitoclax, ABT-737, and dasatinib + quercetin (D+Q) reduce senescent cells, while only D+Q reverses biological age.COVID-19 patient brains exhibit increased senescence, and navitoclax, ABT-737, and D+Q reduce senescence in SARS-CoV-2 infected artificial human brains. The senolytics D+Q and fisetin, but not navitoclax increase the lifespan of
- [NMN Prevents Chemotherapy-Induced Cognition Impairments in Mice](https://www.nmn.com/news/nmn-prevents-chemotherapy-induced-cognition-impairments-mice) - Highlights · Nicotinamide mononucleotide (NMN) prevents chemotherapy-induced abnormalities in brain cells and cognitive function. · NMN’s protective effects on the brain and cognition did not affect tumor growth and anti-tumor efficacy of chemotherapy. Cancer itself is a scary thing, and going through treatment isn’t exactly a walk in the park. Chemotherapy is taxing
- [New Study Shows Combining NMN with Resveratrol or Ginsenosides Synergistically Increases NAD+](https://www.nmn.com/news/nmn-resveratrol-ginsenosides-nad) - Highlights Compared to NMN alone, combining NMN with resveratrol increases NAD+ in the heart and muscle 1.59-fold and 1.72-fold, respectively. In lung tissue, NMN combined with ginsenosides increases NAD+ 1.97 times compared to NMN on its own. These findings point to novel ways of increasing NAD+ in specific organs, paving the way for enhancing NMN’s
- [Scientists Increase Muscle Size and Strength by Restoring Stem Cells with Senolytic Agent](https://www.nmn.com/news/scientists-increase-muscle-size-and-strength-by-restoring-stem-cells-with-senolytic-agent) - Highlights: Senolytics selectively eliminate senescent cells — capable of making other cells dysfunctional. The senolytic fisetin increases the muscle strength and size of mice while reducing tissue scarring. Fisetin reduces senescent fat stem cells, which increases the proportion of functional muscle stem cells needed to regenerate muscle and promote growth and strength. The older we get, the
- [How Are NMN Supplements Made?](https://www.nmn.com/news/how-are-nmn-supplements-made) - Highlights: Chemical synthesis of NMN is the most common method for making NMN supplements but can be hazardous to the environment. Bacterial fermentation of NMN is eco-friendly but slow to produce NMN. Enzymatic conversion of NMN is both eco-friendly and produces higher yields of NMN than bacterial fermentation. In a frantic response to the coming boom in
- [NMN Attenuates Fat Tissue Inflammation and Scarring, New Study Shows](https://www.nmn.com/news/nmn-attenuates-fat-tissue-inflammation-and-scarring-china-study-suggests) - Highlights NMN treatments curtail harmful oxygen deprivation-induced fat tissue scarring (fibrosis) in mice.NMN alleviates fibrosis by reducing inflammatory proteins, and increasing levels of an anti-inflammatory and pro-insulin sensitivity protein called adiponectin.The treatments lessen the abundance of pro-fibrosis and inflammation-triggering protein hypoxia-inducible factor-1ɑ (HIF-1ɑ). Low-grade inflammation driving metabolic conditions like type 2 diabetes and cardiovascular diseases
- [Resveratrol Reduces Brain Cell Inflammation and Senescence, Shows Study](https://www.nmn.com/news/resveratrol-reduces-brain-inflammation-and-senescence-suggests-study) - Highlights: Resveratrol reduces markers of senescence and inflammation in brain cells (astrocytes) from the hypothalamus — a region of the brain that may regulate the process of aging. Treatment with resveratrol activates the gene for sirtuin 1 (SIRT1), an enzyme associated with increased lifespan. The hypothalamus controls everything from our reproductive success to our sleep-wake cycles.
- [NMN vs NR: Scientists Rejuvenate COVID-19 Infected Cells](https://www.nmn.com/news/nmn-vs-nr-scientists-rejuvenate-cells-infected-by-sars-cov-2) - Highlights: In human artery cells infected with SARS-CoV2, NAD+ and nitric oxide (NO) levels are low, and reactive oxygen species (ROS) are high, indicating oxidative stress.NR prevents NO production loss and elevations in ROS. NMN prevents elevations in ROS and nearly prevents NO production losses. Coronavirus 2019 (COVID-19) is now one of the world’s leading causes
- [Natural Antioxidant Apigenin Prevents Cardiac Damage, Scientists Find](https://www.nmn.com/news/natural-antioxidant-apigenin-prevents-cardiac-damage-scientists-find) - Highlights: Apigenin prevents heart enlargement and tissue scarring in a mouse model for cardiac injury. The effects of apigenin are mediated by countering oxidative stress — damage caused to cells by excess levels of reactive oxygen species (ROS). By promoting an increase in NAD+, apigenin is implicated in extending lifespan. According to estimates from the American
- [Clinical Study Shows Tongkat Ali Raises Testosterone and Increases Strength in Older Men](https://www.nmn.com/news/clinical-study-shows-tongkat-ali-raises-testosterone-and-increases-strength-in-older-men) - Highlights: Twelve weeks of 100 mg or 200 mg of Eurycoma longifolia (EL) increases total testosterone in older men with low total testosterone. 200 mg, but not 100 mg of EL increases muscle strength. EL improves perceived symptoms of aging and fatigue, suggesting improved quality of life. With aging, our bones and muscles weaken as body fat
- [Study Shows NMN Delays Stroke in Rodents](https://www.nmn.com/news/study-shows-nmn-delays-stroke-rodents) - Highlights · Defective cell recycling processes favor hypertension-related spontaneous stroke in rats fed high-salt diets. · NMN treatment reverses these processes to protect against stroke occurrence in these rodents. Stroke is a leading cause of mortality and disability and has an array of risk factors including our genetic makeup and lifestyles that increase
- [Harvard Study Demonstrates Multivitamin Supplementation Enhances Memory and Cognition in Older Adults](https://www.nmn.com/news/informative-harvard-study-demonstrates-multivitamin-supplementation-enhances-memory-and-cognition-in-older-adults) - Highlights: Supplementing older adults with a multivitamin (MVM) for two years leads to a modest improvement in global cognition and a significant enhancement in episodic memory – the ability to retrieve information about recent events. A meta-analysis of three cognitive studies evaluating MVM supplementation confirmed that MVM’s positive impact on global cognition was likened to a
- [The Combination of Melatonin and NMN Protects the Aged Heart from Injury](https://www.nmn.com/news/the-combination-of-melatonin-and-nmn-protects-the-aged-heart-from-injury) - Highlights In aged rats with myocardial injury, NMN pre-treatment and melatonin post-treatment had significant cardioprotective effects.The combination of NMN and melatonin can be a promising strategy to attenuate myocardial damage in aged hearts. One major cause of heart failure is what is known in the medical field as myocardial ischemia/reperfusion (I/R) injury — heart damage
- [US Special Forces to Test Anti-Aging Pill Based on NAD+](https://www.nmn.com/news/us-special-forces-nad-based-anti-aging-pill) - Highlights · The US Military has completed pre-clinical safety and dosing studies of an “anti-aging” pill and are gearing up for follow-up performance testing in fiscal year 2022. · The Special Operations Command (SOCOM) is partnering with the company MetroBiotech, advised by anti-aging specialist Dr. David Sinclair, to test
- [Study Demonstrates Anti-Aging Therapy for Pulmonary Fibrosis](https://www.nmn.com/news/study-demonstrates-anti-aging-therapy-pulmonary-fibrosis) - Highlights SIRT3 is decreased in the lungs of individuals with idiopathic pulmonary fibrosis and aged mice with lung injury.Airway delivery of Sirt3 DNA resolves chronic, age-associated lung fibrosis in aged mice. Aging is linked to impaired regenerative capacity. So, it is not surprising that aging is an established risk factor for human fibrotic disorders, defined
- [NAD+ Boosting Protects Human Cells From Premature Aging Disease](https://www.nmn.com/news/nad-boosting-protects-human-cells-from-premature-aging-disease) - Highlights · Mitochondrial dysfunction drives premature aging seen in ataxia telangiectasia (A-T).· Enhancing mitochondrial recycling by boosting NAD+ is a potential therapeutic intervention for (A-T). Ataxia telangiectasia (A-T) is a devastating, complex genetic disorder characterized by degeneration of the nervous system often during infancy or early childhood. Premature aging
- [Study Shows NMN Stops Blood Vessel Aging in Mice](https://www.nmn.com/news/study-shows-nmn-stops-blood-vessel-aging-in-mice) - Highlights · Deficiency of CD38 — an enzyme that consumes NAD+ — alleviates high blood pressure and cardiovascular disease-related blood vessel changes.· NMN supplementation or CD38 inhibition restores cardiovascular function by ameliorating blood vessel cell cycle arrest (senescence). CD38 is the main enzyme for the degradation of nicotinamide adenine
- [Alzheimer’s Drug Failures Beckon the Importance of Prevention](https://www.nmn.com/news/alzheimers-drug-failures-beckon-the-importance-of-prevention) - Highlights: Recent and past pharmaceutical interventions have failed to stop the progression of Alzheimer’s disease. Drug failures could partially be due to scientists focusing too much on one idea. For those not yet afflicted, reducing the risk of Alzheimer’s disease is possible. Certainly not due to a lack of trial and error, Alzheimer’s disease (AD) remains without
- [NMN Limits Breast Cancer Growth and Spread, According to Chinese Study](https://www.nmn.com/news/nmn-limits-breast-cancer-growth-and-spread-according-to-chinese-study) - Highlights NMN inhibits the growth of a common breast cancer form – triple negative breast cancer (TNBC) – that evades typical treatments. NMN significantly improves tumor-bearing mouse survival following breast cancer injection. NMN reduces breast cancer metastasis to lung tissue by activating the pro-longevity protein Sirtuin 1, which repairs DNA and eliminates cell stress. Breast
- [Study Shows Metformin Restores Muscle and Decreases Fat](https://www.nmn.com/news/study-shows-metformin-restores-muscle-and-decreases-fat) - Highlights: Treatment with metformin increases muscle mass, decreases muscle fat storage, and enhances exercise capacity in both sarcopenic mice and sarcopenic obese mice. Metformin decreases muscle inflammation by activating an enzyme called AMPK - a longevity-linked molecule known to increase fat metabolism and reduce inflammation. As we age, the structural integrity of our muscles inevitably deteriorates,
- [Newest Study Indicates NMN Reduces Inflammation and Restores Cognitive Function](https://www.nmn.com/news/newest-study-indicates-nmn-relieves-inflammation-induced-cognitive-impairment) - Highlights: Injecting 500 mg/kg of NMN into the bloodstream of septic mice raises NAD+ and SIRT1 levels in the hippocampus — the region of the brain that consolidates memories. NMN treatment alleviates the cognitive impairments triggered by sepsis-mediated inflammation. Treatment with NMN reduces brain inflammation and oxidative stress — a defect that accompanies inflammation in wreaking havoc on
- [Human Trial Shows NMN Enhances Exercise Endurance in Runners](https://www.nmn.com/news/human-trial-nmn-enhances-exercise-endurance-runners) - Highlights · In middle-aged runners, supplementing 600 to 1200 mg/day of NMN for six weeks improves muscle oxygen absorption and efficient usage for energy production. · The muscle oxygen utilization improvements increased with higher NMN doses during endurance exercise. · No adverse health effects while taking
- [The Anti-Aging Supplements Dr. David Sinclair Takes Besides NMN](https://www.nmn.com/news/the-anti-aging-supplements-dr-david-sinclair-takes-daily-nmn-included) - According to his Book Lifespan and Interviews, Sinclair’s Daily Supplement & Drug Stack is as Follows: Nicotinamide mononucleotide (NMN): 1 g Resveratrol: 1 g Metformin: 800 mgSpermidine: 1 mg Quercetin: 500 mg Fisetin: 500 mg Vitamin D3: 4,000 to 5,000 IU Vitamin K2: 180 to 360 mcgLow-dose aspirin: 81 mgTrimethylglycine (TMG): 500 to 1,000 mg Rapamycin: ? Harvard scientist Dr. David Sinclair
- [Scientists Reveal Vitamin D Prevents Knee Arthritis Via Anti-aging Proteins](https://www.nmn.com/news/scientists-reveal-vitamin-d-prevents-knee-arthritis-via-anti-aging-proteins) - Highlights: Mice with vitamin D deficiency develop osteoarthritis faster than their age-matched counterparts, but supplementing these mice with vitamin D alleviates the osteoarthritis. Chondrocytes – cells thatmake cartilage – which have been exposed to inflammatory molecules and treated with vitamin D show decreased cell aging and cellular stress, both implicated in the development of osteoarthritis.The decreased
- [Study Shows NMN Enhances Immunotherapy and Prolongs Survival](https://www.nmn.com/news/nmn-enhances-tumor-suppression-extends-lifespan) - Highlights: NMN enhances the effect of natural killer (NK) cells — immune cells that kill cancer cells — to increase the lifespan of mice with cancer by nearly 3-fold. NK cell tumor suppression is amplified by NMN in liver cancer mouse model. Tumor growth is also reduced by NMN-treated NK cells in skin cancer mouse model. The true
- [Researchers Report that NMN Coupled with a Compound Found in Chinese Herb Fully Protects the Heart During Chemotherapy](https://www.nmn.com/news/nmn-buckwheat-heart-chemotherapy) - Highlights NMN coupled with a molecule found in buckwheat, troxerutin, fully protects the heart against tissue damage instigated by the chemotherapeutic agent doxorubicin. NMN and troxerutin combined preserve markers of mitochondrial health and new mitochondrial production to protect the heart during chemotherapy. Doxorubicin is a chemotherapy drug used to treat cancers like lymphoma, leukemia, and
- [NMN Increases Telomere Length in Middle-Aged Adults](https://www.nmn.com/news/nmn-improves-telomere-length-blood-cells-middle-aged-people) - Highlights NMN doubles the telomere length of humans over a 90-day period of time. Giving the compound to mice also reduces microbiome bacteria species diversity. As people get older, the repeated DNA sequences at the ends of our chromosomes called telomeres shorten. The erosion of telomeres leads to disorders associated with aging, like metabolic disease
- [Latest Clinical Study Shows Age-Reversing Effects of Resveratrol-Enriched Wine](https://www.nmn.com/news/latest-clinical-study-shows-age-reversing-effects-of-resveratrol-enriched-wine) - Highlights Resveratrol-enriched wine consumed at each meal for three and a half months reverses aging by about three years as shown with an epigenetic age clock.The same wine consumption regimen increases muscle mass by about 300 g over the three-and-a-half-month study period.A body fat mass reduction of 1.6 kg results from the resveratrol-enriched wine consumption
- [Washington University Study Indicates Increasing NMN Transporter in the Brain Mitigates Age-Related Muscle Decline](https://www.nmn.com/news/increasing-nmn-transporter-abundance-brain-mitigates-age-related-muscle-decline) - Highlights Experimentally increasing brain NMN transporter Slc12a8 improves muscle function in aged mice, while reducing NMN transporters in young mice induces muscle decline. These findings suggest an important NMN-mediated connection between the brain and muscle that drives age-related muscle decline (sarcopenia). As we grow older, loss of muscle mass and strength – sarcopenia – facilitates
- [Scientists Find Rapamycin Inhibits Bone Loss by Increasing Mitochondrial Quality](https://www.nmn.com/news/scientists-find-rapamycin-inhibits-bone-loss-by-increasing-mitochondrial-quality-control) - Highlights: Rapamycin heightens mitophagy — mitochondrial quality and quantity control — in a mouse model for bone aging. Bone cell death is reduced by rapamycin treatment. Treatment with rapamycin increases bone mineral density, volume, and thickness. As our mitochondria work hard to generate the cellular energy we need to stay alive, they produce reactive oxygen species (ROS)
- [Study Shows NMN Alleviates Inflammation-Induced Lung Injury in Mice](https://www.nmn.com/news/study-shows-nmn-alleviates-inflammation-induced-lung-injury-in-mice) - Highlights: Mice injected with NMN are protected against lung tissue injury in response to damaging levels of inflammation. NMN reduces inflammatory protein levels in fluid from injured lungs. Protein markers of oxidative stress in response to injury are reduced by NMN. Older individuals are particularly susceptible to sepsis — a life-threatening inflammatory reaction to infection, often starting in
- [New Study Shows that Supplement Spermidine Slows Down Liver Aging](https://www.nmn.com/news/spermidine-slows-degeneration-liver-tissue-integrity) - Highlights Treatment with spermidine increases liver cell viability in the presence of calcium chloride. Feeding spermidine to mice also improves their liver tissue integrity under dietary conditions that promote scarring. Spermidine promotes cell mitochondria generation along with diminishing harmful oxidative stress in cells. As we age, our livers accumulate scar tissue, driving a condition called
- [NMN Boosts the Efficacy of Cancer-Fighting Immune Cells](https://www.nmn.com/news/nmn-increases-cancer-fighting-immune-cells) - Highlights NMN treatment increases CAR-T cell — antitumor immune cell — proliferation up to 180 times, while prolonging the cells’ capabilities to kill cancer cells. With NMN treatment, anticancer CAR-T cells display signs of delayed aging as illustrated by longer telomere lengths and a reduced abundance of dead or dying CAR-T cells. NMN-treated CAR-T cells
- [Fisetin Has Anti-Aging Activity in Human Tissues and Extends Mouse Lifespan](https://www.nmn.com/news/fisetin-anti-aging-human-tissues-mouse-lifespan) - Highlights Fisetin targets biologically aged cells in mice and human tissues.Administration of fisetin to mice late in life reduced age-related disease characteristics and extended median and maximum lifespan. When cells are stressed and need to prevent the replication of damaged DNA, which could lead to cancer, they engage in a process called senescence — an
- [New Study Shows Senolytics Help Reduce Inflammation and Improve Blood Sugar Levels](https://www.nmn.com/news/new-study-shows-senolytics-help-reduce-inflammation-and-improve-blood-sugar-levels) - Highlights: Similar to young mice, old mice treated with dasatinib and quercetin have decreased inflammation in their fat tissue.Dasatinib and quercetin treatments alleviate age-related metabolic dysfunction, leading to improved blood sugar levels and better sugar and insulin tolerance.Treatments with dasatinib and quercetin help reduce liver fibrosis (scarring) and new sugar creation in the liver. Aging
- [New Study Shows Rapamycin Improves Aged Women’s Embryos](https://www.nmn.com/news/new-study-shows-rapamycin-improves-aged-womens-embryos) - Highlights Rapamycin-treated oocytes from aged women mature into high-quality embryos at a higher rate than non-treated ones following insemination. Treated oocytes from aged mice exhibit better chromosome structure and less DNA damage than those that aren’t treated. With rapamycin, reduced levels of harmful, oxygen-containing molecules (reactive oxygen species) that cause cellular stress are found in
- [Latest Findings: Loading Wound Dressing with NMN Accelerates Diabetic Ulcer Healing](https://www.nmn.com/news/latest-findings-adding-nmn-to-wound-dressing-accelerates-diabetic-ulcer-healing) - Highlights Infusing hydrogel dressings with NMN speeds restorative skin healing in a mouse model for diabetic skin wounds.Higher NMN doses added to the hydrogel dressing increase the synthesis and thickness of skin collagen — a structural protein for skin and connective tissue — during healing.Elevated NMN doses in the hydrogel dressing increase gene activity for
- [Telomere Length and Aging](https://www.nmn.com/news/telomere-length-aging) - DNA contains the instructions for life. Every time a cell replicates, it makes two copies of DNA inherited by each of the resulting two cells. Our DNA, and that of any animal and plant, is organized into strings called chromosomes. Because of this structure, every time chromosomes are copied, a tiny bit gets snipped off
- [Two Senolytics Equally Effective in Improving Brain Function: Florida University Study](https://www.nmn.com/news/two-senolytics-equally-effective-in-improving-brain-function-florida-university-study) - Highlights: The senolytics — compounds that remove senescent cells — D + Q and ABT-263 improve the memory of middle-aged rats. D + Q or ABT-263 remove senescent cells — age-promoting cells — from multiple organs, including the lungs, liver, and bone. Each senolytic improves the wiring of the brain, despite ABT-263 being unable to cross into the brain.
- [Study Finds NMN Protects Intestinal Wall from Cancer Radiation Therapy Injury](https://www.nmn.com/news/study-finds-nmn-protects-intestinal-wall-from-cancer-treatment-injury) - Highlights: NMN reduces DNA damage and reactive oxygen species (ROS) in intestinal cells exposed to radiation. In mice, treatment with NMN helps prevent structural impairments caused to the intestinal wall after radiation exposure. Pro-longevity enzymes called sirtuins mediate NMN’s benefits. Radiotherapy is commonly used to treat elderly cancer patients who are often too frail to undergo surgery
- [Chinese Study Shows Bone Formation Requires NMN](https://www.nmn.com/news/human-bone-regeneration-requires-nmn) - Highlights In humans, NMN is necessary for bone stem cells to mature into bone-producing cells called osteoblasts.Enhancing NMN synthesis boosts bone stem cell maturation, produces more osteoblasts, and promotes bone formation.Blocking NMN synthesis impairs bone fracture repair in mice by inhibiting the development of bone stem cells into bone-producing cells. When we break a bone,
- [Female Mouse Infertility Remedied by NMN](https://www.nmn.com/news/nmn-remedies-infertility-in-female-mice-with-mitochondrial-mutations) - As mammals age, fertility decreases and our ability to procreate drops. This fall in fecundity is thought to be linked with the accumulation of mutations in mitochondria, the powerhouses of the cell. These ancient cell structures have their own genetic code that is passed almost exclusively from mother to offspring through the oocyte—the immature egg
- [NMN Reverses Blood Vessel Aging in Middle-Aged Adults with High Weight and Blood-Glucose: Clinical Trial](https://www.nmn.com/news/nmn-reverses-blood-vessel-aging) - Highlights: 250 mg of NMN for 12 weeks does not significantly reduce artery stiffness — a risk factor for cardiovascular disease, dementia, and death — in healthy middle-aged adults. However, NMN reduces artery stiffness in individuals with high blood-glucose and body mass index (weight/height). Blood vessel biological aging is reversed by 2 years with NMN treatment. Nicotinamide
- [Surveying the Current State of NMN Research](https://www.nmn.com/news/surveying-the-current-state-of-nmn-research) - Highlights Animal studies show NMN restores lifespan in premature aging models and improves inflammation and metabolic functioning.Human studies confirm that NMN boosts blood nicotinamide adenine dinucleotide (NAD+) levels, improves markers of healthy metabolism, alleviates fatigue, and enhances physical performance during aging.Future NMN research challenges include determining whether the molecule is the best at boosting NAD+
- [NAD+ Precursors NMN and NR Prevent Nerve Fiber Degradation in Diabetes](https://www.nmn.com/news/nad-nmn-nr-prevent-nerve-fiber-degradation-diabetes) - Highlights Diminished NAD+ levels are restored by nicotinamide riboside (NR) treatment in nerve fibers damaged by diabetes. Administering nicotinamide mononucleotide (NMN) to rats or mice with experimentally-induced diabetes improves nerve function and prevents nerve fiber loss. These findings suggest that supplementing with the NAD+ precursors NMN or NR could prevent the degradation of nerves associated
- [NMN Protects Against Chemo-Induced Mitochondrial Dysfunction: Mayo Clinic](https://www.nmn.com/news/mayo-clinic-scientists-find-nmn-protects-against-chemo-induced-mitochondrial-dysfunction-in-human-neurons) - Highlights: NMN mitigates cellular defects brought about by the chemotherapy drug cisplatin — used to treat cancers like lung, testicular, ovarian, and breast cancer.Treatment with NMN prevents cisplatin-induced disruptions in mitochondrial function, such as reduced production of ATP — cellular energy. NMN prevents cisplatin-induced mitochondrial swelling, a phenomenon that occurs in response to neural injury. “Chemobrain” is
- [NMN Maintains Eye Function and Activates Antioxidants Following Injury](https://www.nmn.com/news/nmn-maintains-eye-function-and-activates-antioxidants-following-injury) - Highlights: Supplementation with NMN prevents retinal dysfunction due to artery occlusion.NMN increases antioxidant production following occlusion.Treatment with NMN reduces inflammatory glial cell activation, suggesting reduced scarring. As we age, we are more likely to suffer from cardiovascular complications, which can lead to retinal dysfunction. The retina – the part of the eye responsible for receiving
- [NMN Prevents Kidney Damage and Restores Kidney Function, Japanese Study Indicates](https://www.nmn.com/news/nmn-prevents-kidney-damage) - Highlights NMN treatment restores essential kidney cells that filter waste (podocytes) and reduces the number of kidney tissue lesions in a mouse model for kidney disease. NMN increases the activation of a pro-longevity enzyme called Sirtuin-1 that reduces kidney cell damage. Our kidneys filter out unwanted material from our bloodstream. As we get older, kidney scarring
- [UNSW Study Shows NMN Corrects Hormonal Disorder-Related Metabolic Dysfunction](https://www.nmn.com/news/study-shows-nmn-corrects-female-hormonal-disorder-related-metabolic-dysfunction) - Highlights NMN supplementation reverses insulin resistance in female mice with PCOS to restore metabolic function. With NMN-induced metabolic restoration, females with PCOS exhibit reduced fat deposits, an indicator of body weight improvement. NMN rescues declining levels of the essential molecule for cell energy and DNA repair – nicotinamide adenine dinucleotide (NAD+) – in the muscle
- [Grape Seed Extract and NMN Protect Mouse Retinal Cells from Aging, Study Finds](https://www.nmn.com/news/grape-seed-extract-boosts-nmn-retinal-cells-aging) - Highlights · A compound from grape seed extract called proanthocyanidin has anti-aging qualities in retinal cells.· The grape seed proanthocyanidin extract (GSPE) works by activating the levels of an enzyme NAMPT that generates NMN, a precursor to NAD+. Our senses enable us to experience the world, especially sight (at
- [New Study Shows NMN Reduces Mortality Risk and Restores Physical Function Following Chemotherapy](https://www.nmn.com/news/new-study-shows-nmn-reduces-mortality-risk-and-restores-physical-function-following-chemotherapy) - Highlights NMN treatment for 10 days increases survival chances and prevents deteriorating heart function following a single high dosage of doxorubicin in mice. A longer-term (chronic) NMN treatment regimen also increases survival odds following doxorubicin treatments spread out over five days. NMN rescues physical function following the longer-term doxorubicin treatment regimen. Doxorubicin is a chemotherapeutic
- [What is Biological Aging and Can It Be Reversed?](https://www.nmn.com/news/what-is-biological-aging) - How do we define aging? Historically, we’ve counted the number of times we live while the Earth orbits the sun (chronological age in years), but nowadays we can also think about the accumulation of cell and tissue damage (biological age). Right now, the aging research field is having a “eureka” moment — we’re rapidly uncovering
- [NMN Induces Metabolic Shift in Damaged Cells to Promote Survival](https://www.nmn.com/news/nmn-circumvents-reduced-nad-levels-cell-damage-response-promote-survival) - Highlights Cell damage initiates a metabolic shift to promote survivalBlocking the damaged cell metabolic pathway leads to cell deathNMN restores damaged cell viability by reversing the metabolic shift As we age, our cells and DNA accrue damage. To offset this, our cells have developed damage sensing responses with a battery of proteins. One such DNA
- [Guard Your Brain: New Study Shows NMN Protects Against Stroke and Prevents Brain Damage](https://www.nmn.com/news/nmn-offers-stroke-protection-and-prevents-blood-brain-barrier-damage-new-study) - Highlights: In a mouse model for blood-brain barrier (BBB) dysfunction, NAD+ levels are low within BBB cells. NMN prevents age-related BBB leakage, an indicator of BBB dysfunction. Pretreatment with NMN reduces brain damage caused by stroke, which is linked to BBB damage. Our BBB protects our brain from toxins in the bloodstream but deteriorates with aging, which
- [NMN and NR Elevate NAD+ Similarly: Walking Longevity Experiment Bryan Johnson](https://www.nmn.com/news/equal-efficacy-of-nmn-and-nr-in-elevating-nad-levels-bryan-johnsons-quest-for-youth) - Highlights: Both NMN and NR raise NAD+ levels similarly after 90 days, as measured from Bryan Johnson’s blood samples.According to his NAD+ levels, Johnson has reversed his biological age by 26 years in 9 months. Whether NMN is more effective than NR remains inconclusive, but both seem to have similar effects. More people, including the likes
- [NMN Eases Neurological Damage Following Traumatic Brain Injury: China Study Confirms](https://www.nmn.com/news/nmn-eases-neurological-damage-following-traumatic-brain-injury-china-study) - Highlights NMN treatment substantially improves learning and memory in rats with TBI. NMN curbs neurological damage from TBI in rats. NMN treatment alleviates the brain’s gene activity signatures indicative of inflammation following TBI. Brain injury is one of the global leading causes of adult disability, with a yearly incidence of about 50 million adults worldwide.
- [NMN and Citicoline Synergistically Shield Against Memory Decline, Study Finds](https://www.nmn.com/news/nmn-and-citicoline-synergistically-shield-against-memory-decline-study-finds) - Highlights: NMN and citicoline synergistically improve the memory of rats with vascular dementia (VD) — dementia from lack of blood flow to the brain. Combined NMN and citicoline reduce the activation of inflammation-promoting microglia cells — the brain’s resident immune cells.NMN combined with citicoline reduces damage to the white matter tracts of the brain. Vascular dementia
- [Study Suggests NMN Can Treat Inflammatory Bowel Disease](https://www.nmn.com/news/study-suggests-nmn-can-treat-inflammatory-bowel-disease) - Highlights: Intestinal mucus secretion is increased by treatment with NMN in mice modeling inflammatory bowel disease (IBD). Intestinal wall leakage is repaired by NMN treatment. Beneficial bacteria called probiotics are elevated by NMN. Aside from pleasure, the food we eat is useless unless the nutrients it contains are absorbed through our intestinal wall. Furthermore, if our intestinal
- [Unveiling NMN’s Remarkable Bone Preservation Abilities in Spaceflight: The Latest Study Findings](https://www.nmn.com/news/unveiling-nmns-remarkable-bone-preservation-abilities-in-spaceflight-the-latest-study-findings) - Highlights NMN revamps bone density in a rat model for weightlessness-induced bone fragility (osteopenia).Levels of the essential, pro-longevity molecule nicotinamide adenine dinucleotide (NAD+) in bone fall during microgravity, but NMN restores bone NAD+.The space travel rat model exhibits higher levels of malondialdehyde, a marker of troublesome oxidative stress in bone, yet NMN normalizes this cell
- [NMN Protects Against DNA Damage-Related Kidney Scarring](https://www.nmn.com/news/nmn-protects-against-dna-damage-related-kidney-scarring) - Highlights · NMN improves cell viability after chemical and oxygen deprivation-induced kidney cell damage. · The NAD+ booster also alleviates kidney tissue scarring from reduced blood flow in mice. Our kidneys, the organs that keep our blood clean and filtered, can be harmed in all sorts of ways. One
- [Scientists in China Reverse Intestinal Aging with NMN](https://www.nmn.com/news/intestinal-aging-nmn) - Highlights: Increasing cellular NAD+ with NMN restores the structure of the intestinal wall in old mice, suggesting improved nutrient absorption. NMN increases the activation of genes associated with gut barrier integrity, providing a means to restore the function of a leaky gut. Intestinal wall fortification is achieved by boosting antioxidant defenses and reducing inflammation via NMN. Our
- [Researchers Restore Cognition In Mice With Traumatic Brain Injury (TBI)](https://www.nmn.com/news/researchers-restore-cognition-mice-traumatic-brain-injury) - Highlights P7C3-A20 is an activator of the rate-limiting enzyme that produces the NAD+ precursor nicotinamide mononucleotide (NMN).Administration of P7C3-A20 in mice with traumatic brain injury (TBI) blocks chronic neurodegeneration and recovers normal cognitive function. A major cause of the long-term disabilities that afflict survivors of traumatic brain injury (TBI) is chronic degeneration of the nervous
- [Is NMN Safe?](https://www.nmn.com/news/is-nmn-safe) - Highlights At doses up to 1200 mg per day over a six-week time course, nicotinamide mononucleotide (NMN) supplementation has proven physiologically safe in humans.Currently, three FDA-regulated clinical trials without published results are in the works as accessed through clinicaltrials.gov.Long-term evaluations are required to examine the reagent’s capacity as safe for consumption. Research shows that nicotinamide
- [NMN Improves Mouse Heart Dysfunction Caused by Scarring](https://www.nmn.com/news/nmn-improves-mouse-heart-dysfunction) - Highlights · NMN alleviates heart muscle enlargement and tissue disorganization in chemically-induced scar tissue buildup.· Boosting NAD+ with NMN activates cell health-maintaining proteins to inhibit genes facilitating fibrosis and dysfunction. Heart scar tissue accumulation (cardiac fibrosis) is a significant contributor to heart failure by increasing the stiffness of heart cavities and diminishing blood
- [NMN Improves Sleep in Middle-Aged and Older Adults: Latest Human Trial](https://www.nmn.com/news/nmn-improves-sleep-in-middle-aged-and-older-adults-latest-human-trial) - Highlights Taking NMN for 12 weeks enhances sleep quality scores evaluated with a sleep test called the Pittsburgh Sleep Quality Index (PSQI). The PSQI revealed that subjects who took NMN took less time to fall asleep than those who didn’t take it. A sleep analysis performed with an electronic wristband indicated that those who took
- [Study Zeroes In On NAD+ Metabolism and α-Ketoglutarate to Combat Obesity](https://www.nmn.com/news/nmn-novel-therapeutic-approach-combat-obesity) - Obesity is a global epidemic that causes numerous metabolic diseases, including type 2 diabetes and cardiovascular disease. The excess accumulation of fat tissue that is characteristic of the disorder results from the increase in both the size and the development of mature fat cells called adipocytes. Discovering compounds able to regulate the size, number, and
- [NMN Prevents Infection and Defends Against Bacterial Invasion: New Study](https://www.nmn.com/news/latest-study-shows-nmn-protects-against-susceptibility-to-infection-when-sleep-deprived) - Highlights: Sleep-deprived (SD) mice have increased susceptibility to bacterial infection, which NMN supplementation prevents. NMN increases the production of an antibacterial molecule called deoxycholic acid (DCA) in SD mouse intestine. When combined with an antibiotic, DCA increases the survival of infected moth larvae by 50%. Sleep deprivation (SD) can lead to cardiovascular disease, cognitive impairment, and intestinal
- [Latest Findings: NMN Reverses Cognitive Impairment from Exposure to Common Environmental Pollutant](https://www.nmn.com/news/latest-findings-nmn-reverses-cognitive-impairment-from-exposure-to-common-environmental-pollutant) - Highlights NP exposure triggers learning and memory impairments in rats, however, NMN (the equivalent to 600 mg per day for humans) restores cognitive function.NMN likely rescues cognition by increasing the quantity of memory-associated receptors — serotonin receptors — in a learning and memory-related brain region, the hippocampus. Banned in the European Union, the hazardous compound
- [Top 4 Recent Breakthroughs for Treating Alzheimer’s Disease](https://www.nmn.com/news/4-breakthroughs-alzheimers-disease) - An estimated 5.8 million people aged 65 and over in the US have Alzheimer’s disease in the year 2020. People with Alzheimer’s disease experience memory loss and confusion as their main symptoms. Patients with Alzheimer’s also frequently have difficulty concentrating, display aggressive behavior, and have irritable dispositions. These hallmarks of Alzheimer’s disease can lead to
- [Latest Japanese Clinical Study Demonstrates NMN's Insulin-Promoting Effect](https://www.nmn.com/news/boosting-insulin-and-nad-levels-in-healthy-adults-promising-discoveries-with-nmn) - Highlights Eleven healthy adults who took 250 mg of NMN for 12 weeks displayed a fivefold increase in blood serum insulin levels after two months.The supplementation regimen substantially raised blood plasma NAD+ levels after the first month, which tapered off with continued NMN usage.The study showed for the first time that taking NMN increases blood
- [Researchers Show Topical NMN Relieves Skin Inflammation](https://www.nmn.com/news/topical-nmn-relieves-inflammatory-skin-disease) - Highlights: The topical application of NMN prevents lesions, itching, rash, and scaling in a mouse model for eczema (inflammatory skin disease). NMN also alleviates signs of skin aging, including excessive reactive oxygen species (ROS) and elevated water loss. Our skin is an external barrier full of immune cells that guard our internal organs against pathogens. Like
- [Mouse Study Shows NMN Can Prevent Diabetic Kidney Disease](https://www.nmn.com/news/nmn-diabetic-kidney-disease) - Highlights · Diabetic mice treated with NMN for two weeks showed improved kidney structure and function, increasing survival. · This treatment paradigm can enhance possibilities for achieving the remission of diabetes-related kidney disorder and other diabetic complications. Up to 40% of patients with diabetes progress to the deterioration of kidney function (a condition
- [New European Study: Restoring NAD+ with NMN Rescues Immune Cell Function Against Hepatitis B](https://www.nmn.com/news/new-european-study-restoring-nad-with-nmn-rescues-immune-cell-function-in-hepatitis-b-patients) - Highlights The nicotinamide adenine dinucleotide (NAD+) precursor NMN improves hepatitis B virus-specific immune cell (CD8 T cell) antiviral activation. Exhausted hepatitis B-specific CD8 T cells with impaired function exhibit high levels of DNA damage and defective DNA repair mechanisms. In their exhausted state, CD8 T immune cells display higher NAD+-consuming CD38 enzyme levels and lower
- [Dr. Huberman's Top 2024 Supplements Beyond NMN](https://www.nmn.com/news/dr-hubermans-top-2024-supplements-beyond-nmn) - Dr. Huberman is on record saying he takes the following supplements daily: NMN: 1-2 g NR: 500 mg Tongkat Ali: 400 mg Fadogia Agrestis: 600 mg, cycled Zinc: 15 mg Boron: 2-4 mg Magnesium L-threonate: 140 mg L-Theanine: 100-300 mg Apigenin: 50 mg Omega-3 Fatty Acids: 2-3 g EPA L-Glutamine: 1 gCreatine: 5 g Vitamin D: 5000-10,000 IU Grapeseed Extract: 400-800 mg Multivitamin Andrew Huberman, Ph.D., is a
- [Study Shows NMN Protects Against Environmentally-Induced Skin Aging](https://www.nmn.com/news/nmn-protects-against-skin-aging) - Highlights: NMN reduces harmful molecules called reactive oxygen species (ROS) in human skin cells exposed to particulate matter. Senescent (aged) cells are elevated in response to particulate matter exposure but reduced by NMN. Treatment with NMN also reduces markers of inflammation and increases levels of the longevity-associated enzyme sirtuin 1. Whether indoors or outside, chances are you
- [NMN Significantly Boosts NAD+ Levels and Enhances Physical Function in Latest Human Trial](https://www.nmn.com/news/nmn-enhances-physical-function-and-perceived-health-especially-at-higher-doses-abinopharm-study) - Highlights Taking NMN at doses of 300 mg, 600 mg, or 900 mg per day for 60 days significantly increases blood levels of the pro-longevity molecule NAD+. Taking these NMN doses for 60 days substantially increases the distance walked over a six-minute period, an indicator of improved physical function. An evaluation measuring perceptions of health
- [NMN Improves Cell Survival and Reduces Inflammation in Dry Eye Disease](https://www.nmn.com/news/nmn-treatment-dry-eye-disease) - Highlights NMN treatment protects eye cell viability under conditions of dry eye disease moisture loss.NMN preserves eye cells by activating DNA maintenance and metabolic health-promoting protein Sirtuin1 (SIRT1).NMN triggers immune cells called macrophages to transition from states of cell killing to healing. Dry eye disease is one of the most prevalent eye disorders and causes
- [Scientists Find NMN Counters Lung Damage Caused by Dust Inhalation](https://www.nmn.com/news/scientists-find-nmn-counters-lung-damage-caused-by-dust-inhalation) - Highlights: NMN treatment reduces lung damage and lung scarring in mice exposed to silica — a mineral constituent of sand found in industrial materials like concrete.Reduced inflammatory cells were seen in the lungs of mice treated with NMN.NMN increases glutathione — a potent antioxidant associated with mitigating the effects of aging. Aging is often
- [NMN Stimulates Metabolic Gene Activity in Fat Cells](https://www.nmn.com/news/nmn-stimulates-metabolic-health-related-gene-activity-in-fat-cells) - Highlights · NMN supplementation increases the activity of metabolism-related genes and diminishes inflammation and scarring-related gene activity in immature mouse fat cells.· If translatable to people, NMN may prevent obesity-related diseases during aging by improving gene activity related to metabolism and reduction of inflammation. As obesity becomes more prevalent
- [Study Demonstrates NMN Can Improve Newborn Health](https://www.nmn.com/news/nmn-improves-oocyte-quality-offspring-health) - Highlights Obese females treated with NMN have oocytes with less DNA damage. NMN administration to obese females improves the structural architecture – actin proteins – of their oocytes, a key marker of oocyte quality. NMN restores the body weight of offspring produced by obese mothers, suggesting the reversal of metabolic defects. With obesity becoming more
- [Scientists Find NMN and Resveratrol  Enhance Cognition in Latest Study](https://www.nmn.com/news/tomato-antioxidant-enhances-cognitive-boosting-effect-nmn) - Highlights: Both NMN and resveratrol improve the spatial learning and memory of aged rats. NMN and resveratrol display senolytic function — elimination of senescent cells (aged cells). The antioxidant craze over the last decades was based on the idea that free radicals cause damage to our cells, leading to disease. A lack of positive results from
- [Japanese Study Indicates NMN Injections Reduce Blood Fat Content in Healthy Individuals](https://www.nmn.com/news/nmn-injections-reduce-blood-fat-content) - Highlights A single injection of NMN reduces blood fat content by about 75%. NMN injections are safely metabolized and cause no discernible damage to the heart, kidney, or pancreas despite bypassing the body’s detoxifier – the liver. The injections boost blood NAD+ levels by about 20%. Rodent studies suggest nicotinamide mononucleotide (NMN) supplementation reverses age-related
- [NMN Antioxidant Activity Prevents Liver Injury in New Study](https://www.nmn.com/news/china-study-shows-nmn-antioxidant-activity-prevents-liver-injury) - Highlights: NMN prevents liver damage in aged mice. Treatment with NMN reduces oxidative stress — damage caused to cells by harmful molecules called reactive oxygen species (ROS). The effects of NMN are mediated by sirtuin3, belonging to a family of enzymes known to increase rodent lifespan. Perhaps the most distinguishing feature setting us apart from other species
- [NMN Reduces Weight, Cholesterol, and Blood Pressure in Overweight Adults: Harvard Study](https://www.nmn.com/news/nmn-reduces-weight-cholesterol-and-blood-pressure-in-overweight-adults-harvard-medical-school-study) - Highlights: A Daily 2,000 mg dose of nicotinamide nucleotide (NMN) for 28 days cuts body weight in overweight or obese middle-aged and older adults.NMN also lowers total blood cholesterol, including low-density lipoprotein (LDL) cholesterol, linked to blood vessel cholesterol buildup.Diastolic blood pressure is lowered by NMN, indicating that it can lower blood pressure. Human studies
- [NAD+ Boosting Drops Treat Age-Related Dry Eye Disease](https://www.nmn.com/news/nad-boosting-drops-dry-eye-disease) - Highlights Age-related testosterone decline causes dysfunction of eye glands that produce oily secretions to the eye, resulting in dry eye disease.Eye drops with NAD+ boosters NMN or NR ameliorate age-related eye conditions by activating a testosterone synthesizing enzyme in aged mice. Within our eyelids are tiny glands that keep our eyes moist, and as we
- [NMN Inhibits COVID-19 Infection, According to Chinese Study](https://www.nmn.com/news/nmn-inhibits-sars-cov-2-infection-according-to-chinese-study) - Highlights SARS-CoV-2 viral entry is higher in human lung cells treated with DNA damage-inducing radiation.Inhibiting DNA repair hinders cell surface accumulation of primary receptors for SARS-CoV-2 (ACE2 receptors), suggesting a link between DNA repair and receptor-mediated viral entry.NMN, known to help repair DNA, dampens cell surface ACE2 receptor buildup along with SARS-CoV-2 viral load in
- [NAD+ Boosting Cocktail Improves Cognition and Brain Structure of Alzheimer’s Patients in Clinical Study](https://www.nmn.com/news/nad-boosting-cocktail-improves-the-cognition-and-brain-structure-of-alzheimers-disease-patients-in-clinical-study) - Highlights: A combination therapy consisting of nicotinamide riboside (NR), L-carnitine, N-acetylcysteine, and serine improves the cognition of Alzheimer's patients. The combination therapy increases brain thickness and volume. Analysis shows the combo improves mitochondrial function. The assumption that Alzheimer’s disease (AD) is caused by proteins called amyloid and tau has led to clinical trial failures. Now scientists are
- [NMN Increases DNA Building Block Production for Mitochondria, Japanese Study Finds](https://www.nmn.com/news/nmn-increases-the-production-of-dna-building-blocks-for-mitochondria-japanese-study-finds) - Highlights Nicotinamide mononucleotide (NMN) increases the concentration of nucleotides in the mitochondria of human cells by increasing the activity of an enzyme called ubiquinone (coenzyme Q10). NMN activates another enzyme that breaks NMN down into a precursor molecule for nucleotides. The findings provide an additional explanation for how NMN improves mitochondrial health. NMN confers anti-aging
- [Transferring Longevity Adaptations Across Species: Gene from Naked Mole Rat Extends Mouse Lifespan](https://www.nmn.com/news/transferring-longevity-dna-across-species-gene-from-naked-mole-rats-extends-mouse-lifespan) - Highlights Mice harboring a naked mole rat gene called nmrHAS2 exhibit 4.4% and 12.2% median and maximum lifespan extensions, respectively.Old mice with the nmrHAS2 gene show a 34% cancer incidence reduction compared to old mice without the gene.Old nmrHAS2 mice display less age-related physical dysfunction as assessed with frailty index scores — evaluations of the
- [Japanese Study Suggests NMN Benefits Sleep and Physical Performance in Older Adults](https://www.nmn.com/news/afternoon-nmn-intake-improves-sleep-and-physical-performance-in-older-adults) - Highlights NMN supplementation improves sleep quality to reduce drowsiness in adults over 65 years old. Better sleep has been shown to improve cognition and physical performance, which may improve aged adults’ outlook on life and the overall number of healthy years people live. As we age, our sleep quality dissipates, facilitating cognitive decline and ultimately,
- [Transforming Gut Health: New Study Shows NMN Fosters Beneficial Bacteria Growth](https://www.nmn.com/news/transforming-gut-health-new-study-shows-nmn-fosters-beneficial-bacteria-growth) - Highlights: NMN inhibits the growth of some gut bacteria while stimulating the growth of others. NMN increases the growth of beneficial gut bacteria called Bacteroides. A beneficial fat called propionate, which Bacteroides produce, is elevated by NMN. Living within our gastrointestinal tract, often referred to as our “gut”, are hundreds of species of bacteria, forming a complex
- [Japanese Study Indicates NMN Reverses Signs of Aging in Older Women](https://www.nmn.com/news/nmn-reverses-aging-older-women) - Highlights Supplementing older women with 300 mg of oral NMN improves sugar and cholesterol metabolism. NMN improves hormone levels as measured by the “mother hormone” – dehydroepiandrosterone sulfate (DHEA-s). Treatment with NMN reduces a process called glycation in the skin, suggesting the reversal of skin aging. Studies using rodents have shown that supplementing with precursors
- [Fat isn’t Always Bad: The Fat Supplements that Prevent Brain Aging](https://www.nmn.com/news/fat-isnt-always-bad-the-fat-supplements-that-prevent-brain-aging) - Highlights: About 2 g/day of DHA, or DHA + EPA, especially in phospholipid form may reverse or prevent cognitive impairment. 100 to 300 mg/day of phosphatidylserine (PS), a phospholipid, may prevent cognitive decline and dementia. 1 mg/day of plasmalogen, another phospholipid, may improve cognition and counteract forgetfulness. Our brain is composed mostly of fat (nearly 60% after
- [NMN Reduces Colitis in Mice](https://www.nmn.com/news/nmn-reduces-colitis-in-mice) - Highlights Deficient NAD+ synthesis in specific immune cells (macrophages) promotes mouse susceptibility to colitis.Macrophage cleaning-up activity that engulfs dead cells and repairs tissue is dependent on NAD+ synthesis.NMN administration mitigates colitis severity and improves mouse survival. Inflammation is at the root of the vital immune response to invaders. First, inflammation activates, recruiting an army of
- [What Are Senescent Cells and Why Are They Being Targeted for Healthier Aging?](https://www.nmn.com/news/what-are-senescent-cells) - Life expectancy has skyrocketed over the last few decades, leaving a billowing trail of diseases linked to aging. An ever-increasing number of scientific studies have honed in on cell senescence as a major contributor to the development of these age-related disorders. For these reasons, cell senescence has become a focus for research institutions and biotech
- [Study Shows NMN Can Protect the Mouse Intestinal Tract by Altering Gut Microbiome Diversity](https://www.nmn.com/news/study-shows-nmn-can-protect-mouse-intestinal-tract-altering-gut-microbiome-diversity) - Highlights · NMN can regulate the structure of the gut microbiota, increase the abundance of probiotics, and reduce the number of harmful bacteria.· These changes in gut microbiome colonization improve the intestinal lining of mice.· By exerting these protective effects on the intestinal lining, NMN may positively impact gut
- [Harvard Scientists Find Solution to Avoid Death Caused by Sleep Deprivation](https://www.nmn.com/news/harvard-scientists-find-sleep-loss-can-cause-death) - Highlights: In flies, sleep-deprivation shortens lifespan by 50% due to gut reactive oxygen species (ROS) — molecules that damage cells when in excessive amounts. Mice that are sleep-deprived also have increased gut ROS.Antioxidants like melatonin and NAD+, which help neutralize ROS, largely prevent sleep-deprived flies from dying early. Over a hundred years of research and we
- [Intestinal Bacterium and NMN Synergistically Enhance Skin Protection](https://www.nmn.com/news/intestinal-bacterium-nmn-enhance-skin-protection) - Highlights · NMN and the gut bacterium L. fermentum eliminate harmful molecules called free radicals.· The combination of NMN and an intestinal bacterium synergistically protects mouse skin from harmful ultraviolet radiation. The skin is one of the most complex organs in our bodies and has an integral connection to the gut. Skin anti-aging
- [NMN Alleviates Lung Damage in Cigarette-Induced Pulmonary Fibrosis](https://www.nmn.com/news/nmn-alleviates-lung-damage-cigarette-induced-pulmonary-fibrosis) - Highlights NMN treatment restores damaged cell cleanup processes to prevent aged, non-proliferating cell buildup following cigarette smoke exposure.Alleviating the buildup of these cells may prevent the progression of the fatal condition pulmonary fibrosis. We all know that smoking is bad for our health. It’s also a major contributing factor to the development of idiopathic pulmonary
- [NMN Improves Diabetes-Induced Male Infertility, New Study Suggests](https://www.nmn.com/news/nmn-diabetes-male-infertility) - Highlights Treating mice with NMN reverses the diabetes-induced shrinkage of seminiferous tubules – tubes in the testes where sperm generation occurs. By restoring testicular abnormalities associated with diabetes, NMN increases sperm count. NMN reduces sperm cell death and increases enzymes important for utilizing the sugar glucose for energy (glycolysis) in diabetic mice. According to the
- [Twelve Weeks of NMN Supplementation More than Doubles NAD+ Levels and Improves Muscle Function, Researchers Find](https://www.nmn.com/news/nmn-supplementation-nad-levels-muscle-function) - Highlights 250 mg of NMN per day for 12 weeks more than doubles blood NAD+ levels in healthy males older than 65. The supplementation regimen improves walking speed and grip strength in the aged men. These findings suggest NMN supplementation may be used to ameliorate age-related muscle deterioration. Nicotinamide adenine dinucleotide (NAD+) is an essential
- [What is Premature Aging and What  Can You Do to Prevent or Reverse It](https://www.nmn.com/news/what-is-premature-aging-and-what-you-can-do-to-prevent-or-reverse-it) - Biological aging describes the process of an organism deteriorating cellularly and functionally. About half of human deaths come from age-related diseases like heart disease, diabetes, chronic kidney diseases, chronic obstructive pulmonary disease, stroke, and Alzheimer’s disease. Also, chronic health problems related to the unprecedented aging of the human population in the 21st century threaten to
- [Metro Biotech Publishes MIB-626 NMN Human Data](https://www.nmn.com/news/nmn-tablet-blood-nad-levels-humans) - Highlights MIB-626 is a pharmaceutical-grade tablet of NMN from Metro International Biotech.This study evaluated the ability of varying oral MIB-626 doses to raise intracellular NAD+ levels.Two 500 mg MIB-626 tablets taken once or twice daily for two weeks doubled NAD+ blood levels in the participants middle-aged and older adults. While several studies in mice and
- [Research Shows NMN Supports Mitochondrial Replication](https://www.nmn.com/news/nmn-enhances-mitochondrial-genome-replication-in-human-cells) - Highlights Japanese researchers examine the role of nicotinamide mononucleotide (NMN) on human mitochondria.Boosting nicotinamide adenine dinucleotide (NAD+) levels with NMN may help deter aging by increasing mitochondrial metabolism. Our cells contain more than one set of DNA: one in our nucleus encodes most cellular processes and another in the energy-generating structure of the cell known
- [Researchers Show NMN Improves Cognitive Deficits in Alzheimer’s](https://www.nmn.com/news/nmn-improves-cognitive-deficits-alzheimers) - Highlights: Treating Alzheimer’s disease (AD) mice with NMN improves their learning and memory. NMN restores energy metabolism, reduces inflammation, and eliminates beta-amyloid, a hallmark of AD.Inhibiting an enzyme that degrades NAD+ called CD38 also reverses AD dysfunction. While the accumulation of a protein called beta-amyloid (Aβ) is undoubtedly involved, the underlying cause of AD is still
- [NMN Improves Stem Cell Therapy for Injured Aged Mouse Hearts](https://www.nmn.com/news/nmn-stem-cell-therapy-injured-aged-mouse-hearts) - Highlights · Mesenchymal stem cells (MSCs) preconditioned with the hormone ghrelin improved the protection of aged mouse hearts subjected to injury.· Injecting NMN with the ghrelin-treated MSCs synergistically improved heart repair after injury. The transplantation of cells found in the bone marrow called mesenchymal stem cells (MSCs), which are important for repairing muscle
- [Aging Expert Matt Kaeberlein’s Carefully Curated Supplement Stack](https://www.nmn.com/news/aging-expert-matt-kaeberleins-conservatively-assessed-supplement-stack) - Highlights Dr. Kaeberlein’s supplement list includes rapamycin, vitamin D, omega-3 fatty acids, vitamin B12, protein shakes with prebiotics and collagen, creatine powder, and magnesium.He is considering taking low-dose tadalafil (also known as Cialis for erectile dysfunction), calcium alpha-ketoglutarate, and urolithin A.His conservative philosophy for choosing supplements entails taking them to fix a measured deficiency, like
- [New Study Finds NAD+ Precursors Promote Wound Healing by Leveraging Skin Regeneration](https://www.nmn.com/news/new-study-finds-nad-precursors-promote-wound-healing-by-leveraging-skin-regeneration) - Highlights: Upon injury, the skin wounds of elderly mice do not fully heal like young mice. The regenerative capacity of skin from elderly mice is impaired, as shown by reduced cell proliferation.Nicotinamide, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) restore elderly skin regrowth to youthful levels. Poor wound healing in the elderly poses a unique problem,
- [Doctor’s Study Indicates COVID-19 Patients Improve with NMN Cocktail Treatment](https://www.nmn.com/news/covid-19-patients-nmn-treatment) - The molecule nicotinamide mononucleotide (NMN) is a promising anti-aging agent that boosts levels of an essential molecule for cellular energy generation and cellular health maintenance called nicotinamide adenine dinucleotide (NAD+). Increasing levels of NAD+ with its precursor NMN has reversed age-related reductions in function of the kidney, liver, brain, vascular, and immune systems in studies
- [Metabolic Benefits of NMN Shown for First Time in Humans](https://www.nmn.com/news/metabolic-benefits-of-nmn-shown-for-first-time-in-humans) - Highlights · This clinical study is the first to report the effectiveness of NMN on human health. · The researchers show that NMN increases blood cell NAD+ levels and improves muscle insulin sensitivity and structure in aged, prediabetic women. The molecule nicotinamide mononucleotide (NMN) has garnered attention for its counteracting effects on metabolic
- [NMN Helps Slow Alzheimer’s Disease Progression](https://www.nmn.com/news/nmn-helps-slow-alzheimers-disease-progression) - Highlights: In AD patients, the mitochondrial stress response is heightened, suggesting damage to brain cell powerhouses. In AD mice, NMN alleviates memory loss and neurodegeneration, the primary symptom and pathology of AD in humans. Mitochondria produce a form of energy our cells utilize to keep us alive. Per ounce, the brain has the highest demand for NMN prevents Alzheimer's disease.
- [Top Aging Scientist Critiques Bryan Johnson’s Attempt to Live Longer Through Gene Therapy](https://www.nmn.com/news/top-aging-scientist-critiques-bryan-johnsons-attempt-to-live-longer-through-gene-therapy) - Bryan Johnson underwent follistatin gene therapy to boost muscle growth and extend lifespan, but Dr. Matt Kaeberlein believes there is insufficient data on safety and efficacy to warrant undergoing the therapy.
- [Grandiose Life Extension Dreams Meet Lax Scientific Scrutiny in Honduras](https://www.nmn.com/news/grandiose-life-extension-dreams-meet-lax-scientific-scrutiny-in-honduras) - Highlights National University of Singapore’s Max Unfried highlights the VitaDAO Life Extension Conference’s goals of speeding up the discovery of longevity interventions.The University of Rochester’s Vera Gorbunova presents research on longevity extension using the seaweed-derived anti-inflammatory fucoidan.Justin Rebo, CEO of Kind Biotechnology, gives a snapshot of current ideas in the realm of organ replacements to
- [The NPA Files Lawsuit Against the FDA Over NMN Ban](https://www.nmn.com/news/the-npa-files-a-lawsuit-against-the-fda-over-nmn-ban) - Highlights In their lawsuit, the Natural Products Association (NPA) requested a ruling that the Food and Drug Administration (FDA) not exclude NMN from being defined as a dietary supplement.The NMN supplement market has suffered a detrimental downturn in the US following an FDA ruling banning the sale of NMN in 2022.According to NPA lawyers, the
- [The FDA Prolongs Its Inaction Regarding NMN](https://www.nmn.com/news/the-fda-prolongs-its-inaction-regarding-nmn) - In March 2023, the Natural Products Association (NPA) and Alliance for Natural Health USA submitted a request to the Food and Drug Administration (FDA). In their request, the organizations asked the FDA not to exclude NMN under the definition of a dietary supplement and commit to not enforcing their existing ban on the sale of
- [Anti-Aging Supplement Rapamycin Slows Muscle and Bone Aging in First Long-Term Clinical Trial](https://www.nmn.com/news/anti-aging-supplement-rapamycin-slows-muscle-and-bone-aging-in-first-long-term-clinical-trial) - Highlights: Supplementing with rapamycin does not lead to serious adverse side effects in older adults. Rapamycin improves muscle mass in women and bone mass in men. Rapamycin — an FDA-approved drug that inhibits mTOR — has proved to be one of the most potent longevity molecules to date, at least for animals. Now, scientists have conducted the Rapamycin slows muscle and bone aging in a sex-dependent manner.
- [Do Blood Transfusions Really Slow Aging? Discover the Science Behind It](https://www.nmn.com/news/do-blood-transfusions-really-slow-aging-discover-the-science-behind-it) - Highlights Dr. Greger reviews research suggesting that certain age-driving factors like possibly malfunctioning protein building blocks (peptides) can be filtered out of blood to rejuvenate tissues and improve cognition in rodents.Researchers applied a technique called plasma exchange therapy, which replaces blood plasma with fresh saline, to Alzheimer’s patients who then experienced 60% less cognitive decline.
- [NMN Stifles Mouse Inflammation Response Like NSAIDs](https://www.nmn.com/news/nmn-stifles-mouse-inflammation-comparable-aspirin-ibuprofen) - Highlights · NMN treatment alleviates the inflammatory response of immune cells called macrophages. · Supplementing with the molecule also inhibits the buildup of inflammation-associated proteins, including COX-2. · By dampening COX-2 accumulation, NMN targets inflammation like non-steroidal anti-inflammatory drugs (NSAIDs). In a vicious cycle, inflammation in any body region like the joints
- [Study Shows NMN Enhances Activation of Cancer-Fighting Immune Cells](https://www.nmn.com/news/study-shows-nmn-enhances-cancer-preventing-immune-cell-activation) - Highlights · NMN increases natural killer cell capabilities to destroy cancer cells (cytotoxicity) without increasing immune cell numbers.· The study supports that taking NMN may be a way to rejuvenate natural killer immune cell activation to preserve tissue health during aging. As the average human lifespan increases, people are experiencing poor health and
- [NMN Protects Against Colon Cancer, New Study Finds](https://www.nmn.com/news/nmn-protects-against-colon-cancer-new-study-finds) - Highlights: NMN injections prevent the development of colon tumors in a mouse model for colon cancer. NMN reduces biological drivers of aging, including inflammation, in the colon of colon cancer mice. Colorectal cancer — colon and rectal cancer — is the third leading cause of cancer-related death globally. For this reason, compounds that prevent the development of colorectal NMN protects against colon cancer.
- [New Longevity Treatment Trend: Aging Athletes and CEOs Use Plasma Exchange](https://www.nmn.com/news/new-longevity-treatment-trend-aging-athletes-and-ceos-use-plasma-exchange) - Plasma exchange therapy—where blood plasma is replaced with fresh saline—is a new fad among athletes and CEOs seeking to enhance longevity.
- [Brad Stanfield and Matt Kaeberlein’s New Rapamycin Aging Clinical Trial Measuring Strength and Endurance](https://www.nmn.com/news/brad-stanfield-and-matt-kaeberleins-new-rapamycin-aging-clinical-trial-measuring-strength-and-endurance) - Highlights: Strength and endurance will primarily be measured by how many times participants can stand up from and sit down on a chair for 30 seconds. Walking speed and grip strength will also be measured, along with quality of life and various blood markers of aging, including an inflammatory marker. The hypothesis is that rapamycin will deter New rapamycin clincial trial details.
- [Ashwagandha Root Extract Improves Cognition, Physical Performance, and Sleep](https://www.nmn.com/news/ashwagandha-root-extract-improves-cognition-physical-performance-and-sleep) - Highlights: Ashwagandha has been shown to reduce frailty and improves cognition, quality of life, walking speed, and sleep. Previous studies also suggest that ashwagandha may slow muscle and brain aging. Ashwagandha (Withania Somnifera) is an Ayurvedic medicine, used in India for thousands of years as a general tonic. Studies have shown that supplementing with ashwagandha relieves Ashwagandha counteracts aging.
- [NR Counteracts the Metabolic Aging Effects of Processed Food, New Study Suggest](https://www.nmn.com/news/nr-counteracts-the-metabolic-aging-effects-of-processed-food-new-study-suggest) - Highlights: NR counteracts fructose-induced weight gain in mice. NR promotes the fat-burning potential of fat cells by stimulating a phenomenon known as browning. Fructose, especially high-fructose corn syrup, is found in many processed foods, including fast food. Chronic consumption of fructose has been shown to lead to obesity and metabolic dysregulation (high triglycerides and insulin resistance) NR protects against age-accelerating processed foods.
- [Aging Scientist Applies Her Research to a Longevity-Promoting Lifestyle](https://www.nmn.com/news/aging-scientist-applies-her-research-to-a-longevity-promoting-lifestyle) - Aging scientist Mary Ní Lochlainn has applied her research to a longevity-promoting lifestyle that includes regular exercise, vitamin D supplementation, and intermittent fasting.
- [Biohacker Strives for a 150-Year Life, Shares Latest Age-Defying Secrets — Including Sleeping in a Faraday Cage](https://www.nmn.com/news/biohacker-strives-for-a-150-year-life-shares-latest-age-defying-secrets-including-sleeping-in-a-faraday-cage) - #post_excerptBiohacker tries to slow aging by sleeping in a cage.
- [Can Eating Diverse Foods Delay Aging?](https://www.nmn.com/news/can-eating-diverse-foods-delay-aging) - Highlights Dietary diversity—measured by self-reported intake of foods from five major food groups—is associated with slowed aging.This connection may be due, in part, to reduced oxidative stress—an accumulation of reactive, cell-damaging molecules.These findings highlight the potential importance of a broad-spectrum diet rich in macro- and micronutrients as well as antioxidants to slow aging and prevent
- [Latest Findings: Taking Vitamin D Associated with Lowering Blood Pressure](https://www.nmn.com/news/latest-findings-taking-vitamin-d-associated-with-lowering-blood-pressure) - A new study associates vitamin D supplementation with lowering blood pressure in overweight elderly individuals.
- [81-Year-Old Biohacker Claims His Biological Age is 18](https://www.nmn.com/news/81-year-old-biohacker-claims-his-biological-age-is-18) - Octogenarian Kenneth Scott spends around $70,000 annually for his aging intervention routine and claims his biological age reads 18.
- [Federal Court Halts Enforcement Against NMN](https://www.nmn.com/news/federal-court-halts-enforcement-against-nmn) - A federal court has issued a ruling that the Food and Drug Administration (FDA) halts its enforcement actions against nicotinamide mononucleotide (NMN) supplements.
- [Supplements Outvote Anti-Aging Drugs Metformin and Rapamycin](https://www.nmn.com/news/supplements-outvote-anti-aging-drugs-metformin-and-rapamycin) - Highlights: According to a survey, people are more willing to partake in anti-aging supplements (e.g. NMN) than any other anti-aging intervention. Exercise was the second most-voted anti-aging intervention, followed by intermittent fasting, metformin, and rapamycin. As life expectancy has increased, so too has chronic illness and disease. For this reason, scientists have begun focusing on targeting People are more willing to take anti-aging supplements than drug.
- [Could Space Be the Secret to Unlimited Stem Cells? Inside Cedars-Sinai’s Revolutionary Experiment](https://www.nmn.com/news/could-space-be-the-secret-to-unlimited-stem-cells-inside-cedars-sinais-revolutionary-experiment) - Cedars-Sinai is growing stem cells in space to harness microgravity for scalable production, aiming to revolutionize treatments for age-related diseases.
- [The Top NMN and NR Supplements of 2024](https://www.nmn.com/news/the-top-nmn-and-nr-supplements) - Highlights The top NMN and NR supplements are as follows:RESTORINThorne NiaCel 400ProHealth Longevity’s NMN Pro CompleteQuicksilver Scientific NAD+ PlatinumCymbiotika NMN + Trans-ResveratrolRevigorator The products chosen that include the top NAD+ precursor molecules nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) combine multiple ingredients. Adding multiple molecules with possible age-slowing benefits may confer interactions between these compounds
- [Stanford Neurology Professor Robert Sapolsky on Stress, Inflammation, and Accelerated Aging](https://www.nmn.com/news/stanford-neurology-professor-robert-sapolsky-on-stress-inflammation-and-accelerated-aging) - Dr. Mark Hyman interviews Dr. Robert Sapolsky who relays how chronic stress can facilitate elevated levels of the stress hormone cortisol, which drives age-related cognitive conditions.
- [Researchers Speculate Ozempic May Slow Aging](https://www.nmn.com/news/researchers-speculate-ozempic-may-slow-aging) - Highlights In a trial tracking more than 17,600 people over the age of 45 who were overweight or obese and had cardiovascular disease, those who took semaglutide died at a lower rate from all causes.In the same trial, semaglutide also lowered chances of heart failure symptoms and cut inflammation regardless of whether or not participants
- [Fasting Increases Length of Life but Resilience Matters Too](https://www.nmn.com/news/fasting-increases-length-of-life-but-resilience-matters) - Highlights: Dietary restriction — fasting and cutting calories — prolongs the lifespan of mice but with high variability. Resilience to stress is strongly associated with whether dietary restriction prolongs lifespan. Immune system health and genetic background are also strong determinants. Cutting calories is the only natural way to lose weight. However, whether this strategy is conducive to Resilience from stress promotes longer life.
- [New Study Predicts Maximum Human Lifespan with DNA Chemical Modification Analysis](https://www.nmn.com/news/new-study-predicts-maximum-human-lifespan-with-dna-chemical-modification-analysis) - Highlights Longer-lived mammalian species like humans showed lower rates of disorder in methylation (referred to as epigenetic entropy) than shorter-lived species.Statistical analyses of epigenetic entropy data suggested that humans have a maximum lifespan of about 118 years, comparable to the longest-documented human lifespan of 122.5 years.For mammals more generally, statistical assessments pointed to a maximum
- [What the New Kidney Disease Study Says About NR and CoQ10](https://www.nmn.com/news/what-the-new-kidney-disease-study-says-about-nr-and-coq10) - Key Points: Supplementing with either NR (nicotinamide riboside) or CoQ10 increased gene activity related to metabolism and immunity.CoQ10 supplementation significantly reduced protein markers of inflammation in the blood.NR improved the functional capacity of the cell powerhouse—mitochondria—as suggested with a measurement called the bioenergetic health index (BHI). Up to now, very little evidence exists suggesting that
- [Jimmy Carter Turns 100 to Vote in This Year's Presidential Election: The Power of Purpose in Longevity](https://www.nmn.com/news/jimmy-carter-turns-100-to-vote-in-this-years-presidential-election-the-power-of-purpose-in-longevity) - Highlights: Carter’s family has said Jimmy is sticking it out until this year’s presidential election with his money on Harris. Carter has also been eating healthy and exercising his whole life while challenging himself, helping others, being friendly, and practicing Christianity. Jimmy Carter, the 39th U.S. president, led the country from 1977 to 1981, leaving presidency Is Jimmy Carter living long enough just to vote against Trump?
- [What’s the Difference Between NMN, Niacin, and Vitamin B3?](https://www.nmn.com/news/whats-the-difference-between-nmn-niacin-and-vitamin-b3) - Highlights: Nicotinic acid/niacin, nicotinamide/niacinamide, and nicotinamide riboside are different forms of vitamin B3, while NMN is not.Each form of vitamin B3 offers unique benefits, including lowering cholesterol and counteracting skin aging. Studies have shown that nicotinamide riboside and NMN have similar effects. In a world of facts and plentiful information, confusion surrounds the similarities and differences
- [60-Year-Old Lenny Kravitz’s Secrets to Age Defiance](https://www.nmn.com/news/60-year-old-lenny-kravitzs-secrets-to-age-defiant-youthfulness) - Legendary rock star Lenny Kravitz maintains an ageless look by eating vegan, exercising regularly, and practicing relaxation techniques.
- [Could the Blind See Again? Neuralink’s Blindsight Clears FDA Hurdle](https://www.nmn.com/news/could-the-blind-see-again-neuralinks-blindsight-clears-fda-hurdle) - Neuralink's Blindsight implant receives FDA breakthrough designation, aiming to restore vision for individuals with blindness.
- [This Is How You Can Slow Aging: Dr. Andrew Huberman and Dr. Casey Means Reveal Mitochondrial Hacks](https://www.nmn.com/news/this-is-how-you-can-slow-aging-dr-andrew-huberman-and-dr-casey-means-reveal-mitochondrial-hacks) - Dr. Andrew Huberman and Dr. Casey Means explain how mitochondrial dysfunction accelerates aging and how diet, exercise, and fasting can support healthy aging.
- [Longevity Expert Explains How Bryan Johnson Has Not Reduced His Pace of Aging by 31 Years](https://www.nmn.com/news/longevity-expert-explains-how-bryan-johnson-has-not-reduced-his-pace-of-aging-by-31-years) - Highlights: Epigenetic clocks have great predictive power in determining the probability of human disease and mortality risks. While Bryan Johnson has reduced his epigenetic age, suggesting potential improvements in longevity, his calculation for reducing his pace of aging by 31 years is unsubstantiated. Bryan Johnson has spent millions of dollars to devise an anti-aging regimen called Bryan Johnson hasn't reversed his age as much as he claims.
- [50% Chance 40-Year-Olds Do Not Die from Aging: Longevity Expert Aubrey de Grey](https://www.nmn.com/news/people-over-40-have-50-50-chance-of-never-dying-of-aging-gerontologist-aubrey-de-grey) - Aging researcher Aubrey de Grey believes those who are currently 40-years-old have more than a 50% chance of never dying of aging.
- [Could Activating a Longevity Gene Extend Our Lives?](https://www.nmn.com/news/could-activating-a-longevity-gene-extend-our-lives) - Highlights Increasing OSER1 gene activity prolongs the lives of silkworms, nematode worms, and flies.Although the function of OSER1 remains largely unknown, researchers showed that it works against cell stress, which may lead to lifespan extension.Mutations in this gene have been linked to longer lifespans in humans. Published in Nature Communications, Dai and colleagues from Southwest
- [How NMN Could Protect the Brain from Wild Fire Smoke and Other Pollutants](https://www.nmn.com/news/how-nmn-could-protect-the-brain-from-wild-fire-smoke-and-other-pollutants) - Highlights: NMN prevents brain inflammation, memory loss, and anxious behavior in mice exposed to fine particles often found in polluted air and smoke. NMN may protect the brain by restoring cellular fat levels. Within the polluted air are unseen and potentially dangerous particles collectively known as particulate matter (PM). Smaller in diameter than human hair, PM
- [Our Mitochondria May Be Killing Us: New Research from Columbia University](https://www.nmn.com/news/how-the-mitochondria-in-our-brain-reduce-life-by-over-10-years-new-research-from-columbia-university) - Highlights: For every two additional mitochondrial DNA insertions, there was a 10-year reduction in life. Scientists are still trying to determine how to stop mitochondrial DNA insertions. Scientists from Columbia University, University of Michigan, and Rush University have discovered that individuals with no cognitive impairment (NCI) are more likely to die earlier if they have more
- [Peter Attia on Prolonging Life: Should You Take Statins Without Having Symptoms?](https://www.nmn.com/news/peter-attia-on-prolonging-life-should-you-take-statins-without-having-symptoms) - Highlights: In a recent study, heart disease was observed in one-third of asymptomatic individuals, which was associated with LDL cholesterol levels. Dr. Attia alludes to taking LDL cholesterol-lowering drugs to mitigate the risk of heart disease. While statins can lower LDL levels, so can diet and exercise. Heart disease is the number one leading cause of death
- [Inside Russia’s Plan to Extend Lifespan and Develop New Anti-Aging Technologies](https://www.nmn.com/news/inside-russias-plan-to-extend-lifespan-and-develop-new-anti-aging-technologies) - Highlights: The Russian government has requested that research institutions develop anti-aging technologies to prolong lifespan. Medical experts doubt whether this can be accomplished promptly without proper funding. A lack of talent may also hamper the Russian leadership’s goal of extending lifespan. According to Meduza, the president of Russia, Vladimir Putin, 71, recently announced a new project aiming
- [Mitrix Bio’s CEO Unveils Bold Plan to Extend Human Lifespan to 130 Years](https://www.nmn.com/news/mitrix-bios-ceo-unveils-bold-plan-to-extend-human-lifespan-to-130-years) - Highlights Tom Benson shows how the DNA in mitochondria degrades with age, which likely impairs mitochondrial function and correlates with chronic conditions like heart disease and dementia.He plans to harvest stem cells from patients to grow more mitochondria then transplant the mitochondria back into the patients.Using this technique, Tom Benson aims to extend human lifespan
- [The Top Longevity Clubs for the Rich](https://www.nmn.com/news/the-top-longevity-clubs-for-the-rich) - How much do you spend at the gym monthly? $30? $40? Maybe close to $100? Some people spend 100x that on longevity-focused health and wellness club memberships. Let’s take a look at some of the most notable of these ultra-fancy gyms. MOST SCI-FI CHIC: REMEDY PLACE ($24,000 per year) In the lower price range is
- [Longevity Scientist Debunks that NMN Triggers Kidney Toxicity](https://www.nmn.com/news/longevity-scientist-debunks-that-nmn-triggers-kidney-toxicity) - Highlights: A recent mouse study showed that NMN promotes kidney inflammation and damage. Longevity scientist Dr. Brenner says this could potentially be from contaminated NMN. Many animal studies have shown that NMN is beneficial to the kidneys. In a recent episode of The Optispan Podcast, host Matt Kaeberlein, PhD, asked guest Charles Brenner, PhD, about a recent
- [How a Tissue-Rejuvenating Vaccine Could Transform Aging and Recovery](https://www.nmn.com/news/how-a-tissue-rejuvenating-vaccine-could-transform-aging-and-recovery) - Highlights Dr. Scieszka’s vaccine consists of virus-like particles that present protein markers which also exist on the surface of blood vessel senescent cells.The immune system reacts to and mounts a response against the protein markers to subsequently target senescent cells in blood vessels and possibly throughout the body.Injecting mice with the vaccine prolonged their lifespans
- [Eating Less Food 2 Days Per Week Reverses Diabetes, Outperforming Most Prescribed Anti-Diabetes Drug Metformin](https://www.nmn.com/news/eating-less-food-2-days-per-week-reverses-diabetes-outperforming-most-prescribed-anti-diabetes-drug-metformin) - Highlights: 5:2 intermittent fasting improves blood sugar control more than the anti-diabetes pharmaceuticals metformin and empagliflozin. 5:2 intermittent fasting leads to significantly greater weight loss than metformin and empagliflozin. Cancer, heart disease, and neurodegenerative disorders are more likely to develop in individuals with type 2 diabetes (T2D). Fortunately, T2D is one of the few chronic age-related
- [Cognitive Rejuvenation Achieved with Advanced Therapy Pioneered by David Sinclair’s Lab](https://www.nmn.com/news/cognitive-rejuvenation-achieved-with-advanced-therapy-pioneered-by-david-sinclairs-lab) - Highlights: A gene therapy injected directly into the brain prevents learning impairments in aged rats. The gene therapy delivers genes called Yamanaka factors, which cause cells to revert to an earlier stage of development, making them appear younger. Cancer, previously shown to be induced by Yamanaka genes, was not detected in this study. Renowned Harvard professor David
- [Nicotinamide Riboside Brain NAD+ Elevations Measured for First Time in Healthy Adults](https://www.nmn.com/news/nicotinamide-riboside-brain-nad-elevations-measured-for-first-time-in-healthy-adults) - Highlights: As measured by MRI, brain NAD+ levels were elevated in 9 healthy individuals four hours after ingesting NR. Future studies may determine whether raising brain NAD+ levels can combat age-related conditions, such as neurodegeneration and reduced fertility. The latest research shows that NAD+ levels decline with age in the brain. Furthermore, low brain NAD+ levels
- [Combination of NMN, Probiotic, and Prebiotic Reduce Alzheimer's Brain Plaques by 67%](https://www.nmn.com/news/combination-of-nmn-probiotic-and-prebiotic-reduce-alzheimers-brain-plaques-by-67) - Highlights: The NMN, L. plantarum, and lactulose combo reduces Alzheimer’s plaques in regions of the brain associated with consciousness, thinking, and memory. Previous studies suggest that NMN, L. plantarum, and lactulose could work synergistically to improve cognition. In addition to progressive memory loss, cognitive decline, and neurodegeneration, Alzheimer’s disease (AD) features the abnormal accumulation of amyloid-β
- [Lithium Anti-Aging Benefits: A Deep Dive into Its Potential](https://www.nmn.com/news/the-anti-aging-benefits-of-lithium-a-deep-dive-into-its-potential) - Highlights: Lithium has been shown to extend the lifespan of fruit flies and nematodes. A 300 µg dose of lithium was shown to prevent cognitive decline while 42 mg to 336 mg was shown to improve cognitive function in Alzheimer’s patients. Lithium, a naturally occurring mineral, has long been recognized for its role in psychiatric treatment,
- [Glutathione – The Super Antioxidant: Benefits and Role in Longevity](https://www.nmn.com/news/glutathione-the-super-antioxidant-benefits-and-role-in-longevity) - Glutathione (GSH) is a powerful antioxidant produced in the liverthat supports longevity by reducing oxidative stress and enhancing cellular detoxification.
- [Removing the Harmful Effects of Microplastics in Human Body](https://www.nmn.com/news/how-to-reduce-the-harmful-effects-of-microplastics-on-your-body) - Highlights: Anti-aging supplements like NAD+ precursors and antioxidants may protect against cellular damage caused by pervasive environmental microplastics.Compounds called senolytics may deter cellular transformations that occur in response to microplastics.Avoiding microplastic intake by becoming aware of environmental exposures may help prevent the aging accelerating effects of microplastics. In our modern world, microplastics have become an
- [How Old Are You Really? Scientists Use Thermal Imaging to Find Out](https://www.nmn.com/news/how-old-are-you-really-scientists-use-thermal-imaging-to-find-out) - Highlights Using an imaging device called ThermoFace, researchers identify facial regions where temperatures are linked to aging and disease.Data suggests that nose temperatures decrease while eye and cheek temperatures increase with age and that participants with metabolic conditions have higher eye area temperatures.The research team found that jumping rope for two weeks reduced biological age
- [Hollywood Stars Like Matt Damon and Kevin Hart Pour $53 Million Into Longevity Platform](https://www.nmn.com/news/hollywood-stars-like-matt-damon-and-kevin-hart-pour-53-million-into-longevity-platform) - Highlights Function’s star-studded list of backers includes Hollywood actors Matt Damon, Kevin Hart, and Zac Effron, along with sports stars Blake Griffin and Colin Kaepernick.For $499 a year, Function provides access to more than 100 lab tests measuring things like heart health, hormone levels, immunity, and aging factors.In an effort to help people live 100
- [Columbia University Research Reveals the Impact of Our Thoughts on Mitochondrial Health](https://www.nmn.com/news/columbia-university-research-reveals-the-impact-of-thoughts-on-mitochondrial-health) - Highlights: What we think and feel has long been associated with health outcomes and longevity, but the biological basis for this has yet to be determined. For the first time, scientists have linked the mental state of older adults with mitochondrial energy output. The study supports therapies like NMN, which could counteract the physiological consequences of adverse
- [Tips from Harvard’s David Sinclair: How to Eat and Build Muscle for Longevity](https://www.nmn.com/news/tips-from-harvards-david-sinclair-how-to-eat-and-build-muscle-for-longevity) - Highlights Dr. Sinclair says eating protein from plants gives the optimal ratio of protein building blocks (amino acids) for longevity.As for exercise, Dr. Sinclair says that a little goes a long way and recommends running a few miles, doing yoga, and/or lifting weights every other day.Exercising the back, hip, and upper thighs, he says, is
- [Exploring the Longevity Paradox: Can Obesity Increase Lifespan or Is BMI an Inadequate Measure?](https://www.nmn.com/news/the-obesity-paradox-is-more-fat-better-for-living-longer) - Highlights: Specific obese individuals have lower mortality rates than non-obese individuals.Body mass index (BMI) is a poor indicator of health, whereas abdominal obesity more accurately predicts mortality risk. Exercise can lower the chances of premature death from obesity. Considering that obesity is generally thought to lead to a shorter life, the obesity paradox arises from studies
- [Star Trek’s William Shatner Joins Ambitious Project Aiming to Extend Life Expectancy to 130](https://www.nmn.com/news/star-treks-william-shatner-joins-ambitious-project-aiming-to-extend-life-expectancy-to-130) - Highlights William Shatner is now on the oversight committee of Biotech Explorers, a startup aiming to extend human life expectancy to 130 years.The ambitious initiative wants to protect astronauts’ bodies from the harsh conditions of space and extend healthy lifespans on Earth with transfusions of new mitochondria — the cell’s powerhouse.Including Shatner in the collaboration
- [An Aging Vaccine in Seven Years](https://www.nmn.com/news/an-aging-vaccine-in-seven-years) - Highlights Dr. Nag has entered a competition called Xprize that will award him $101 million if he can develop a way to extend older adults’ lifespans by 10 to 20 years.For Dr. Nag’s Xprize entry, he plans to develop a vaccine against aging using preexisting FDA-approved drugs that will be chosen based on AI computer
- [Fungus to Replace Steroids: Stem Cell Recruitment and Muscle Recovery](https://www.nmn.com/news/fungus-to-replace-steroids-stem-cell-recruitment-and-muscle-recovery) - Highlights: Ingesting 1 g of Cordyceps sinensis before intense exercise speeds up the expansion of stem cells that regenerate muscle. Cordyceps sinensis also leads to an earlier resolution of muscle damage after exercise. Previous studies have shown that Cordyceps sinensis increases the lifespan of mice by 10%, raises NAD+ levels, and improves aerobic performance in humans. As
- [Are Senolytics a Road to Better Mental Health and a Longer Life?](https://www.nmn.com/news/are-senolytics-a-road-to-better-mental-health-and-a-longer-life) - Highlights: Despite its influence on premature mortality, age-related mental illness is scientifically underexplored in the longevity space. Older individuals with major depression and bipolar disorder may have higher levels of age-associated senescent cells. Senolytics may alleviate symptoms of mental illness by targeting senescence-associated accelerated aging. While the onset of mental illness usually occurs during adolescence and early
- [Dr. Brad Stanfield’s Four Key Takeaways After Reading All 18 NMN Human Studies](https://www.nmn.com/news/dr-brad-stanfields-four-key-takeaways-after-reading-all-18-nmn-human-studies) - Highlights: Stanfield says that much of the expectations involving NMN surround early mouse studies showing improvements in muscle performance and metabolic health. Based on his analysis, Stanfield says that human studies have not yet met these expectations. Stanfield’s takeaways may be premature, and more studies that include more participants are needed. New Zealand’s Dr. Stanfield is a
- [Peter Attia’s Stance On Touted Longevity Interventions: Rapamycin, Metformin, Resveratrol, and Fasting](https://www.nmn.com/news/peter-attias-stance-on-popular-geroprotective-interventions-rapamycin-metformin-resveratrol-and-fasting) - On The Drive Podcast, Dr. Attia discusses the geroprotective potential of the following molecules and interventions: rapamycin, metformin, resveratrol, fasting, and caloric restriction.
- [New Harvard Study Shows NMN Increases the Lifespan of Naturally Aging Mice](https://www.nmn.com/news/new-harvard-study-shows-nmn-increases-the-lifespan-of-naturally-aging-mice) - Highlights: NMN increases the lifespan of female mice by 8.5% but does not increase the lifespan of male mice, perhaps because NMN metabolism is increased in females. NMN improves the health of both male and female mice but in a sex-dependent manner. NMN increases the abundance of beneficial gut bacteria, which are also abundant in people who
- [Dr. Brad Stanfield on the Science Suggesting Taurine Slows Aging](https://www.nmn.com/news/dr-brad-stanfield-reviews-research-suggesting-taurine-may-slow-aging) - Highlights A compelling human study suggests that taurine decreases blood pressure, blood sugar, triglycerides, cholesterol, and insulin levels.Taurine extends worm lifespan by 23% and mouse lifespan by 12%.Given the safety profile of taurine, the encouraging animal studies, and the positive human data, Dr. Stanfield supplements with about 1 gram of taurine daily. Dr. Brad Stanfield
- [Renowned Scientist Greg Fahy Claims Breakthrough in Human Body Rejuvenation](https://www.nmn.com/news/renowned-scientist-greg-fahy-claims-breakthrough-in-human-body-rejuvenation) - Highlights Dr. Fahy orchestrated a trial where participants were injected with a cocktail consisting of two hormones and the diabetes drug metformin to reactivate their thymus.After a year of undergoing the treatment, participants saw significantly reduced age based on an aging clock analyzing DNA modifications and had inflammation cut in half.Dr. Fahy also talks about
- [A Sneak Peek of Sinclair's MetroBiotech Lab and New NMN Clinical Trials](https://www.nmn.com/news/a-sneak-peek-of-sinclairs-stunning-metrobiotech-lab-and-new-nmn-clincial-trials) - Highlights: Metro Biotech just released a video showing their lab and describing some of their projects, including potentially making new NAD+ precursors into drugs. The video mentions three Phase 2 clinical trials for MIB-626 NMN that are currently recruiting. Metro Biotech believes NAD+ precursor treatment may potentially treat over 50 diseases by targeting mitochondria. Metro International Biotech
- [NMN Relieves Despair from Social Stress, New Study Shows](https://www.nmn.com/news/nmn-relieves-despair-from-social-stress-new-study-shows) - Highlights: 100 mg/kg of NMN fed to mice for 3 weeks reduces depressive-like behavior induced by social defeat stress. NMN increases NAD+ levels and cellular energy in a region of the brain associated with depression. A new study suggests that social stress leads to lower NAD+ levels in a region of the brain that regulates emotions
- [NMN Prevents Physical Decline and Poor Sleep: Latest Clinical Trial](https://www.nmn.com/news/nmn-prevents-physical-decline-and-poor-sleep-latest-clinical-trial) - Highlights: Twelve weeks of NMN supplementation prevents a decline in how long it takes to walk 13 feet.NMN also prevents a decline in sleep quality. Our walking speed reflects the vitality of our muscles, bones, and nervous and cardiovascular systems. In this way, our walking speed can predict how long we may live. However, the
- [Bryan Johnson’s Tips for Longevity: Vagus Nerve Stimulation for Stress Reduction](https://www.nmn.com/news/bryan-johnsons-tips-for-longevity-vagus-nerve-stimulation-for-stress-reduction) - Highlights Using a vagus nerve stimulating device, Bryan Johnson believes he has lowered his stress, improved his mood, enhanced his digestion, and reduced his body’s inflammation.He partially attributes vagus nerve stimulation with increasing his heart rate variability (HRV) — a measure reflecting the heart’s adaptability and resilience to stress. The entrepreneur and venture capitalist Bryan
- [Living Longer May Be Pointless, Experts Predict It's Too Late](https://www.nmn.com/news/living-longer-may-be-pointless-experts-predict-its-too-late) - Highlights: Climate scientists believe that rising global temperatures will inevitably arouse war, famine, death, and other calamities. Such calamities are predicted to occur by the year 2100.Meanwhile, longevity experts believe individuals alive today will live beyond the year 2100. Almost 80% of the world’s leading climate scientists predict that the earth will reach apocalypse-triggering temperatures, according
- [Life-Extending Gene Therapies: Successes, Failures, and Secrets](https://www.nmn.com/news/life-extending-gene-therapies-successes-failures-and-secrets) - Highlights: A promising new, possibly life-extending, gene therapy has been shown to reduce the symptoms of heart disease and improve exercise performance. Past age-reversing gene therapies were studied in the shadows of government regulation and have been called into question. The latest results from the EXACT Phase II trial show that a new gene therapy reduces
- [Dr. David Sinclair Steps Down from Prominent Aging Research Position Amidst Backlash Surrounding ‘Reverse Aging' Claim](https://www.nmn.com/news/disgraced-david-sinclair-resigns-from-top-aging-academy) - Highlights Dr. Sinclair was elected president of the non-profit organization with goals of promoting future longevity work called the Academy for Health and Lifespan Research in June 2023.A barrage of rebukes from fellow longevity researchers over his claims of “age reversal” in primates and dogs drove Dr. Sinclair to step down as president in March
- [Innovative Drug  Improves Vision In Blind People](https://www.nmn.com/news/innovative-drug-improves-vision-in-blind-people) - Highlights: CRISPR gene editing technology was used to improve the eyesight of individuals with a rare disease caused by a genetic mutation that leads to vision loss and blindness. The CRISPR drug was designed to remove said genetic mutation, allowing the eye’s light-detecting cells to function properly. Before the FDA approves the new CRISPR drug, more funding
- [Bryan Johnson's Anti-Aging Blueprint Protocol Includes an Ingredient You Might Not Expect](https://www.nmn.com/news/bryan-johnsons-anti-aging-blueprint-protocol-includes-an-ingredient-you-might-not-expect) - Bryan Johnson includes high-flavonol pure cocoa in his anti-aging regimen to capitalize on its potent health benefits.
- [FDA Halts NMN Supplement Approval, Citing Pharmaceutical Potential](https://www.nmn.com/news/fda-bans-labeling-nmn-as-a-supplement) - The FDA has issued a statement saying that NMN may not be sold as a supplement, citing its status as being under investigation as a drug. This development is a reversal of the FDA’s previous decision to allow its sale as a new dietary supplement (NDI). Although many vitamin and supplement companies that sell NMN
- [Top NMN Supplement Delivery Systems](https://www.nmn.com/news/top-nmn-supplement-delivery-systems) - Highlights: There are many different methods for delivering NMN on the market, including capsules, powder, suppositories, mouth sprays, and nasal sprays. The top delivery system may be capsules that are pH-sensitive and designed to bypass the acidity of the stomach. Individuals contemplating taking NMN supplements may be wondering about its best mode of delivery. While many overlook
- [Dr. Peter Attia Reveals His Top 5 Supplements in 2024](https://www.nmn.com/news/dr-peter-attia-reveals-his-top-5-supplements-in-2024) - Longevity expert Dr. Peter Attia’s top 5 supplements in 2024 include magnesium, creatine, methylated B vitamins, curcumin, and fish oil.
- [How Always Being Angry Can Shorten Your Life](https://www.nmn.com/news/how-always-being-angry-can-shorten-your-life) - Highlights: A bout of anger impairs blood vessel relaxation for 40 minutes in young adults. Anxiety and sadness do not impair blood vessel relaxation, suggesting that each of our emotions affect our health and physiology differently. Researchers from Columbia University have found that anger impairs the relaxation of blood vessels in young adults. These findings may
- [Viral Sensation Chuando Tan Leaves People Speechless at 58 with His Ever-Lasting Youthful Look](https://www.nmn.com/news/viral-sensation-chuando-tan-leaves-people-speechless-at-58-with-his-ever-lasting-youthful-look) - By following more conventional health practices, like strength training and eating whole foods, 58-year-old Chuando Tan has preserved his youth.
- [Crucial Element of Young Blood That Extends Life Discovered](https://www.nmn.com/news/crucial-element-of-young-blood-that-extends-life-discovered) - Highlights: Young extracellular vesicles (EVs) prolong the lifespan of older mice by 12.42%. Molecules called microRNAs within the EVs improve mitochondrial health. EV therapy may be a thing of the future, but supplements like NMN can also improve mitochondrial health. In the past few decades, scientists have discovered nanosized messengers in our blood that spread information to
- [Scientist Disagrees with David Sinclair’s Claims Regarding Dog Anti-Aging Supplement "Leap Years"](https://www.nmn.com/news/david-sinclairs-claims-regarding-dog-anti-aging-supplement-leap-years-are-a-lie-according-to-expert) - Key Points: In a press release from Animal Biosciences, David Sinclair is quoted as saying they have developed the first supplement “proven to reverse aging in dogs.”Matt Kaeberlein has said that this statement “is a lie” and has left a prestigious group for which Sinclair was president. Animal Biosciences has since corrected Sinclair’s quote so it
- [Can Intermittent Fasting Cause Heart Disease? Experts Slam Viral Study](https://www.nmn.com/news/can-intermittent-fasting-cause-heart-disease-experts-slam-viral-study) - Research links an 8-hour daily eating window and 16-hour fast to increased risk of death from heart and circulatory diseases.
- [Longevity Enthusiast Aging Slower than Bryan Johnson Takes These Supplements](https://www.nmn.com/news/longevity-enthusiast-aging-slower-than-bryan-johnson-takes-these-supplements) - Highlights Dave Pascoe is leading longevity guru Bryan Johnson in a contest to reverse aging called the Rejuvenation Olympics.In an effort to attain his position ahead of Johnson, Pascoe takes over 100 supplements five days a week, giving his body a break from supplementation on the weekends.Some of Pascoe’s most important supplements are discussed. In
- [Peter Attia Reveals His Greatest Mind and Body Tips for Each Decade of Life](https://www.nmn.com/news/peter-attia-reveals-his-greatest-mind-and-body-tips-for-each-decade-of-life) - Highlights: Tips for easing the mind throughout life include not being too self-critical, focusing on emotional health, and doing things you enjoy. Tips for maintaining the body throughout life include resistance exercise, cardiovascular exercise, and balancing exercises. Peter Attia, M.D., is a practicing physician, author of Outlive: The Science and Art of Longevity, and host of
- [Mind Blowing: Biological Robots Repair Neurons When Free](https://www.nmn.com/news/mind-blowing-robot-lung-cells-heal-neuronal-tissue-when-free) - Highlights: When lung cells are grown in the absence of a prison-like matrix, they form fully-motile spherical biological robots called anthrobots. When placed into areas of damaged neuronal tissue, the anthrobots promote the growth of new neuronal tissue, suggesting their reparative properties. As published in Advanced Sciences, researchers from Tufts University unveil their discovery of anthrobots
- [Meet the Digital You: Exciting New AI-Driven Longevity Medicine](https://www.nmn.com/news/meet-the-digital-you-exciting-new-ai-driven-longevity-medicine) - Highlights: Virtual representations of our body can be used to predict disease while simulating treatment outcomes, potentially leading us to live longer lives. Wearable and implantable sensors can be used to continuously measure both our biological state and the state of our external environment. Before this technology can be implemented, hurdles such as costs and susceptibility to
- [The Buck Institute’s Eric Verdin on How to Potentially Prolong Your Life by 12 to 14 Years](https://www.nmn.com/news/the-buck-institutes-eric-verdin-on-how-to-potentially-prolong-your-life-by-12-to-14-years) - Highlights Dr. Verdin reviews five tips that may extend your lifespan 12 to 14 years: regular exercise, minimizing alcohol consumption, not smoking, a healthy diet, and maintaining optimal weight.Dr. Verdin also gives a rundown of potential age-delaying compounds under investigation such as rapamycin, nicotinamide riboside, and metformin.He goes on to predict that the Food and
- [Spectators Thrilled for New Steroid Olympics](https://www.nmn.com/news/spectators-thrilled-for-new-steroid-olympics) - Highlights: The Enhanced Games is similar to the Olympic Games but allows performance-enhancing drugs (PEDs) like anabolic steroids. The ethos of the Enhanced Games revolves around the idea that banning PEDs is anti-science. The Enhanced Games are like the Olympic Games but without the drug testing. Yet, the differences don’t stop there. Unlike Olympic athletes, Enhanced
- [Rapamycin: A Promising Game-Changer for Longevity Enthusiasts](https://www.nmn.com/news/rapamycin-a-promising-game-changer-for-longevity-enthusiasts) - Highlights Some physicians are prescribing rapamycin — an FDA-approved drug for organ transplant recipients — for off-label purposes as an anti-aging treatment.Despite research showing rapamycin extends lifespan in yeast, flies, worms, and mice, its promise as a longevity drug in humans remains controversial among experts.High-profile rapamycin users like Bryan Johnson and Peter Attia have promoted
- [8-Hour Time-Restricted Eating Linked to a 91% Higher Risk of Cardiovascular Death?](https://www.nmn.com/news/8-hour-time-restricted-eating-linked-to-a-91-higher-risk-of-cardiovascular-death) - Highlights: Researchers determined which participants were on an 8-hour time-restricted eating (TRE) diet by averaging two days of dietary recall information. This method of determining who is following an 8-hour TRE routine is unreliable. “8-hour TRE” was correlated with an increased risk of cardiovascular mortality. Researchers from Shanghai Jiao Tong University in China have identified a correlation
- [Rifampicin and Resveratrol Nasal Spray Prevents Dementia in Preclinical Study](https://www.nmn.com/news/nasal-spray-dementia) - Highlights Nasal spray containing rifampicin and resveratrol significantly improved mouse cognition.This nasally administered mixture reduced toxic proteins that drive neurodegeneration. How can you treat a disease before symptoms show? This puzzle has stymied researchers and pharmaceutical companies developing preventative treatments (prophylactics) for neurodegenerative dementia. One thing is to address the problem conceptually — a drug
- [Holiday Shopping Guide for Aging & Longevity Science Fans](https://www.nmn.com/news/holiday-shopping-guide-aging-longevity-science) - In this season of giving, you can give gifts that'll keep them around healthier and happier for longer. Here are some suggestions for gadgets that can improve the wellbeing of your loved ones. Find your age through your gut: Viome Health Intelligence Test · Get wellness insights and personalized nutrition recommendations for
- [Super-Heroes and Ultra-Healers: The Real-World Science of Deadpool’s Immortality](https://www.nmn.com/news/superheroes-ultra-healers-science-deadpool-immortality) - Deadpool, the fourth-wall-breaking comic book hero turned movie star known as the “merc with a mouth,” is effectively immortal. No matter which way he gets sliced and diced, he does not die. Cursed by Thanos, one of the most villainous characters in the Marvel Universe, barring him from reaching “his lady” death, Deadpool sometimes shoots
- [NMN Extends Fast-Aging Mouse Life and Prevents a Leaky Gut](https://www.nmn.com/news/nmn-extends-fast-aging-mouse-life-and-prevents-a-leaky-gut) - Highlights NMN extends the median as well as the maximum lifespan in a mouse model of premature aging.Supplementing with NMN restores multiprotein complexes that are crucial to intestinal barrier formation — tight junctions — in healthy, middle-aged mice.NMN also beneficially restructures the gut microbial composition — the microbiome — of middle-aged mice. Published in Food
- [Dr. Huberman Says Keeping NMN on the Market as a Supplement Would Be Wonderful](https://www.nmn.com/news/dr-huberman-says-keeping-nmn-on-the-market-as-a-supplement-would-be-wonderful) - Highlights: NMN was initially acknowledged as a supplement by the FDA but due to the actions of Metro International Biotech, it has been banned from being sold as a supplement. Dr. Huberman says that the ban could be reversed if many letters are sent to the FDA demanding its unbanning. As a guest on The Joe
- [Juvena's Breakthrough: AI Drug Discovery for Restoring Aged Muscle](https://www.nmn.com/news/juvenas-breakthrough-ai-drug-discovery-for-restoring-aged-muscle) - Highlights Juvena Therapeutics has received the FDA’s orphan drug designation — providing tax incentives for conducting clinical trials — for its drug JUV-161.JUV-161 human trials will begin toward the end of the year with hopes of restoring muscle and improving strength and endurance in patients with a condition of progressive muscle weakening — myotonic dystrophy
- [Unlock Longevity: Study Reveals Gene Therapy Boosts Mouse Life](https://www.nmn.com/news/unlock-longevity-study-reveals-gene-therapy-boosts-mouse-life) - Highlights The gene therapy extended the remaining lifespan by 109% for 124-week-old mice (equivalent to ~77 years for humans).This technique also reduced age-related frailty, where muscles become weak and bones become delicate.Aged mice and human skin cells showed age reversal as measured with an analysis of DNA molecular tagging patterns following gene therapy. In a
- [Chris Hemsworth’s 4 Longevity Habits for Averting Alzheimer’s](https://www.nmn.com/news/chris-hemsworths-4-longevity-habits-for-preventing-alzheimers) - Highlights: Various lifestyle factors, including maintaining blood pressure levels, avoiding excessive alcohol, and using the sauna can reduce the risk of Alzheimer’s for everyone. Hemsworth does a lot of meditation and breathwork and focuses more on endurance exercise rather than muscle building. He avoids screens and reads books before bed to get better sleep and spends more
- [How An Ageless Future Would Affect Society](https://www.nmn.com/news/how-an-ageless-future-would-affect-society) - Highlights Contrary to critics, based on artificial intelligence (AI)-based calculations, the Earth could support about 132 billion people if they consume chicken and about 33 billion people if they eat beef.As for supposed water shortages, using new desalination techniques, where sea water is turned to drinking water, the world’s water may be able to support
- [Bryan Johnson Reveals How He Reversed Hair Loss and Greying](https://www.nmn.com/news/bryan-johnson-reveals-how-he-reversed-hair-loss-and-greying) - Highlights: Bryan Johnson’s hair loss reversal routine includes a red light therapy cap, a customized topical formulation, microneedling, and exosome therapy. To mitigate hair graying, Johnson utilizes two topical formulations: GR7 and Mayraki. Johnson asserts that “The best time to work on your hair is before you start losing it…Otherwise, it’s harder to catch it.” Bryan Johnson,
- [Are Anti-Aging Clinics Worth the Price Tag?](https://www.nmn.com/news/are-anti-aging-clinics-worth-the-price-tag) - Highlights The Miora longevity clinic measures 90 blood markers to gauge the rate of aging.Based on the blood analyses, Miora recommends lifestyle changes, supplements, medications, hormone replacement therapies, and vitamin-infused IV drips.Miora also offers pressurized chambers that increase cellular oxygen and purportedly promote healing as well as cold temperature exposure to tamp down inflammation. Longevity
- [Neuronal Stimulation Extends Lifespan by Activating NMN Synthesis](https://www.nmn.com/news/crosstalk-between-the-brain-and-fat-tissue-regulates-aging-and-lifespan-suggests-latest-study) - Highlights Aging dysregulates neurons within a brain region called the hypothalamus, impeding fight-or-flight signals to fat tissue.Stimulating these neurons improves physical activity and modestly extends lifespan in mice through the release of an NMN-synthesizing enzyme (eNAMPT) from fat tissue. A seminal study published in Cell Metabolism from Imai and colleagues at Washington University in St.
- [Is NMN the New Rogaine?](https://www.nmn.com/news/is-nmn-the-new-rogaine) - Highlights: In the cells responsible for generating new hair, NMN may promote hair growth by contributing to blood vessel formation and reducing inflammation.The effect of NMN on fur regrowth in mice is similar to that of no treatment at all. Researchers from Guangxi University in China report in Molecules that NMN promotes hair growth. This
- [Anti-Aging Researchers Unravel Longevity Secrets of a 93-Year-Old Man with the Heart Fitness of a 30-Year-Old](https://www.nmn.com/news/anti-aging-researchers-unravel-longevity-secrets-of-a-93-year-old-man-with-the-heart-fitness-of-a-30-year-old) - Highlights Researchers in Ireland are studying how a 93-year-old man, Richard Morgan, maintains an optimal physical condition.Morgan’s cardiovascular health resembles that of a 30- or 40-year-old.To maintain his physical fitness, Morgan does rowing exercises for 40 minutes a day, rowing around 18.5 miles weekly. Researchers at the University of Limerick in Ireland conducted a case
- [What Are Senolytics and How Can They Stifle Aging?](https://www.nmn.com/news/what-are-senolytics-and-how-can-they-stifle-aging) - Highlights According to one theory, senescent cell accumulation reaches a threshold during aging where the immune system cannot control their buildup.Animal models have shown that senescent cell buildup facilitates age-related diseases and that senolytics like dasatinib and quercetin alleviate them.Completed human trials with senolytics have shown that these compounds improve physical function in frail individuals
- [Can You Buy Unlimited Lifespan? The Longevity Biotechnology Fellowship Has a Roadmap](https://www.nmn.com/news/can-you-buy-unlimited-lifespan-the-longevity-biotechnology-fellowship-has-a-roadmap) - Rarely are great achievements made without careful planning, and the Longevity Biotechnology Fellowship (LBF) plans to solve aging. The LBF is a community of self-proclaimed Longevity Accelerationists — forward-thinking scientists, engineers, investors, and luminaries with a common vision: “Accelerate humanity’s transition to a post-aging future. Where healthy lifespan, of unlimited length, is available to all.”
- [Staying Hungry Drives Younger Blood, Mayo Clinic Discovers](https://www.nmn.com/news/eating-less-reduces-age-driving-molecules-in-human-blood-mayo-clinic-discovers) - Highlights: Middle-aged adults who reduced their calories by 25% (average of 12%) over 2 years tended to have lower levels of potentially age-driving proteins in their blood. These potentially age-driving proteins predicted the incidence of insulin signaling dysregulation. As part of the most exhaustive and thorough study of its kind, scientists from the Mayo Clinic,
- [117-Year-Old Woman Ate the Same Daily Diet Low in Fruits and Vegetables for Nearly 100 Years](https://www.nmn.com/news/117-year-old-woman-ate-the-same-daily-diet-low-in-fruits-and-vegetables-for-nearly-100-years) - Highlights Emma Morano, who died in 2017 at the age of 117, was unmarried throughout most of her adulthood, saying that she did not want to be dominated by anyone.She ate the same diet for nearly 100 years, starting after World War I, that consisted of egg- and chicken-based meals with low fruit and vegetable
- [Common Blood Pressure Medication Thwarts Smoker’s Lung and Reverses Emphysema Damage, New Study Finds](https://www.nmn.com/news/common-blood-pressure-medication-targets-smokers-lung-and-reverses-emphysema-damage-new-study-finds) - Highlights: Smoking cigarettes significantly damages the lungs and triggers the formation of senescent (dysfunctional) cells in lung tissue, contributing to the development of various lung diseases. In preclinical models, treatment with benidipine targets senescent lung cells and reduces lung damage caused by emphysema, a harmful lung disease characterized by the destruction of alveoli – tiny air
- [Nicotinic Acid vs. NMN: Impact on NAD+ Levels and Epigenetic Age Acceleration](https://www.nmn.com/news/nicotinic-acid-vs-nmn-impact-on-nad-levels-and-epigenetic-age-acceleration) - Highlights: Nicotinic acid increased Lustgarten’s blood NAD+ to about the same level as NMN but required a little more than 1/4th the dose. Nicotinic acid seems to have accelerated Lustgarten’s rate of aging. At-home testing kits for measuring NAD+ levels and aging rates are available to anyone who can spare around $500. A 600 mg dose of
- [New Study Shows NMN Prolongs the Lifespan of ALS Mice, by Boosting NAD+?](https://www.nmn.com/news/new-study-shows-nmn-prolongs-the-lifespan-of-als-mice-by-boosting-nad) - Highlights: Feeding NMN to ALS mice extends their median lifespan by about 3.5%. NMN delays the onset of movement dysfunction and preserves nerve-to-muscle signaling. NMN does not raise NAD+ levels in normal mice, but the researchers did not measure NAD+ levels in ALS mice. As reported in Experimental Neurology, researchers from the University of Missouri have shown
- [Bryan Johnson's Top Three Anti-Aging Compounds: How the Science Measures Up](https://www.nmn.com/news/bryan-johnsons-top-three-anti-aging-compounds) - Highlights: Bryan Johnson takes over 50 supplements and medications per day to slow his aging. Rapamycin, taurine, and acarbose seem the most promising of these anti-aging compounds considering that they have been shown to increase the lifespan of both male and female mice. Over the past few years, millionaire Bryan Johnson has devised an anti-aging protocol
- [Swiss Scientists Develop a Diabetes Drug Activated by Music](https://www.nmn.com/news/swiss-scientists-develop-a-diabetes-drug-activated-by-music) - Highlights: Human pancreas cells were genetically engineered to harbor vibration-sensitive proteins that activate insulin release in response to music. The highest levels of insulin release from music occur with the song “We Will Rock You” by Queen. Treating diabetes mice with capsules of engineered cells lowers their blood sugar levels, suggesting a potential novel diabetes therapy. It
- [Lycopene, A Potent Antioxidant, Significantly Strengthens Weak Bones, New Study Finds](https://www.nmn.com/news/potent-antioxidant-found-in-tomatoes-significantly-strengthens-weak-bones-new-study-finds) - Highlights: Lycopene supplementation preserves bone mass and increases bone strength and density in a mouse model of osteoporosis. Supplementing osteoporotic mice with lycopene significantly reduces cellular senescence – a dysfunctional cellular state known to promote osteoporosis and aging itself. Cellular senescence stands as a critical hallmark of aging, driving the deterioration of several fundamental biological processes
- [NMN Prevents Clogged Arteries and Protects Against Plaque Bursting, A New Study Shows](https://www.nmn.com/news/nmn-unblocks-arteries-and-protects-against-artery-bursting-a-new-study-shows) - Highlights: NMN prevents artery plaque buildup and the fat deposits within, suggesting the suppression of atherosclerosis. NMN protects against plaque bursting by reducing the accumulation of dead cells and fats within artery plaques. Researchers have found that NMN not only hinders the genesis of atherosclerosis — artery plaque buildup — but also protects against the plaque bursting
- [Aging Research Gains Copious Funding and Aims to Define Causes of Aging](https://www.nmn.com/news/aging-research-gains-copious-funding-and-aims-to-define-causes-of-aging) - Highlights Researchers seek a better understanding of what underpins aging.Researchers are using DNA molecular tagging (epigenetics) and DNA activation (transcriptomics) to determine whether anti-aging therapeutics reverse aging.Identifying what underpins aging on long-lived species like naked mole rats may help researchers design new anti-aging therapies. “Finally, finally,” says Vera Gorbunova, an aging researcher and co-director of
- [NAD+ Precursors May Counteract Vision Loss in Glaucoma](https://www.nmn.com/news/nad-precursors-may-counteract-vision-loss-in-glaucoma) - Highlights Preclinical trials in mice suggest glaucoma, an eye disease characterized by damage to nerves signaling visual information to the brain, begins with the deterioration of neuronal projections (axons) from eye cells (retinal ganglion cells [RGCs]) that relay visual information to the brain.RGC axonal deterioration is a result of low nicotinamide (NAM) adenine dinucleotide (NAD+)
- [UCLA Study Reveals Young Pig Plasma Reverses Organ Aging and Age-Related Cognitive Decline](https://www.nmn.com/news/ucla-study-reveals-young-pig-plasma-reverses-organ-aging-and-age-related-cognitive-decline) - Highlights: Injecting aged rats with plasma – the liquid portion of blood – from young pigs reverses the biological age of their liver, heart, and brain. Plasma treatment enhances learning and memory, and mitigates two hallmarks of aging: oxidative stress and inflammation. Animal studies have demonstrated that young plasma contains several critical factors capable of supporting
- [Italian Study Shows Anti-Diabetic Drug Boosts NMN & Omega-3 Levels](https://www.nmn.com/news/latest-cardiac-aging-advancement-italian-researchers-boost-hearts-nmn-omega-3-levels-using-empagliflozin) - Highlights: Empagliflozin raises NMN and DHA levels in normal human heart cells, suggesting potential anti-aging effects.NMN and DHA levels are also increased by empagliflozin in human heart cells exposed to high glucose, suggesting potential protection from diabetes-induced heart damage. High blood glucose from diabetes wreaks havoc on the body, including the heart and, if severe
- [Revitalizing Female Reproduction: How Spermidine Transforms Aging Oocytes To Increase Fertility](https://www.nmn.com/news/revitalizing-female-fertility-how-spermidine-transforms-aging-oocytes-to-increase-fertility) - Highlights: Aged oocytes have lower spermidine levels than young oocytes. Supplementing aged 52-week-old mice (similar to a 44-year-old) with spermidine restores spermidine levels and improves the quality of oocytes, leading to increased fertility. The beneficial effects of spermidine on oocyte health rely on the activation of mitophagy – the clearing and recycling of defective mitochondria inside a
- [Consuming Seaweed Reduces Muscle Loss and Raises Testosterone, Korean Study Shows](https://www.nmn.com/news/consuming-seaweed-reduces-muscle-loss-and-raises-testosterone-korean-study-shows) - Highlights: Seaweed extract increases the strength of middle-aged and older adults. Seaweed extract and anabolic steroids similarly elevate testosterone in old mice to reach levels largely equal to young mice. Muscle mass is also increased in old mice to similar levels as young mice with both seaweed extract and anabolic steroids. Sarcopenia — age-associated muscle and strength
- [Pawsitively Groundbreaking: Life-Extending Drug for Dogs Clears FDA Hurdle](https://www.nmn.com/news/pawsitively-groundbreaking-life-extending-drug-for-dogs-clears-fda-hurdle) - Highlights: Loyal’s unpublished research suggests LOY-001 increases lifespan in large dog breeds. By 2026, Loyal hopes to secure conditional approval from the FDA, allowing them to bring the drug to market while still conducting additional comprehensive lifespan experiments. When it comes to our beloved four-legged friends, we find ourselves grappling with the inevitable reality that we
- [Stanford Study Shows Small Molecule Treatment Restores Nerve Function and Enhances Strength](https://www.nmn.com/news/stanford-study-shows-small-molecule-treatment-restores-nerve-function-and-enhances-strength) - Highlights: In mice, levels of an enzyme called 15-PDGH significantly increase in muscle following nerve damage.Blocking 15-PGDH promoted regeneration of motor neurons and accelerated recovery.15-PGDH is a marker of muscles affected by neurogenic myopathies in human subjects, supporting the therapeutic potential of this treatment. Researchers from Stanford University School of Medicine and Sanford Burnham Prebys
- [Harvard’s David Sinclair and Celebrity Biochemist Rhonda Patrick: Eating Bright-Colored Plants to Extend Lifespan](https://www.nmn.com/news/harvards-david-sinclair-and-celebrity-biochemist-rhonda-patrick-eating-bright-colored-plants-to-extend-lifespan) - Highlights Aging researcher Dr. David Sinclair explains how plants grown under stressful conditions produce bright-colored fruits that, when consumed by people, may activate cellular defenses and longevity pathways.Dr. Rhonda Patrick highlights how polyphenols like curcumin, found in turmeric, turn on anti-inflammatory genes and detoxifying enzymes that may improve brain function and extend the number of
- [Dr. Brad Stanfield’s Nine Supplements to Slow Aging](https://www.nmn.com/news/dr-brad-stanfields-nine-supplements-to-slow-aging) - Dr. Brad Stanfield recommends the following nine supplements to extend healthspan, the period of your life where you are healthy and disease free: Creatine: 5 g per dayProtein powder: 1.62 g/kg (0.74 g per pound) of body weight daily for younger adults or 2 g/kg (0.9 g per pound) of body weight daily for older
- [Training for Longevity with Bryan Johnson: How to Strengthen Knees to Fight Against Age-Related Frailty](https://www.nmn.com/news/training-for-longevity-with-bryan-johnson-how-to-strengthen-knees-to-fight-against-age-related-frailty) - Highlights The longevity-focused fitness program centered around using sleds and treadmills and focused on exercises like squats and lunges.Beginners can easily implement these short routines into their schedules every few days to bolster knee strength and stave off incapacitating effects from age-related frailty. According to the Centers for Disease Control and Prevention (CDC), approximately 18%
- [Intermittent Fasting: Stanford’s Andrew Huberman Describes an Efficient Fat-Loss Technique Promoting Healthspan](https://www.nmn.com/news/intermittent-fasting-stanfords-andrew-huberman-describes-an-efficient-fat-loss-technique-promoting-healthspan) - Highlights During an extended fast, a period where no food is consumed, insulin and blood sugar levels decrease while other hormones like metabolism-promoting growth hormone increase, creating a state that triggers body fat metabolism.Timing the intake of food is important to induce a fasting state, which has been associated with leaner body mass, increased fat
- [Keto Diet Keeps Aging Mice Strong Without Building Muscle](https://www.nmn.com/news/keto-diet-keeps-aging-mice-strong-without-building-muscle) - Highlights: Aged mice fed ketogenic diets show improved muscle strength and coordination compared to mice fed normal diets.These improvements in muscle performance were not linked to increases in muscle size but, instead, to increases in the connectivity between the nervous system and muscles. ​​The ketogenic diet is all the rage as a fat-loss method, but
- [My Experience Taking the Senolytic NAD+ Enhancer Revigorator](https://www.nmn.com/news/my-experience-taking-the-senolytic-nad-enhancer-revigorator) - Highlights Taking two capsules of Revigorator in the morning gave me a small jolt of energy within 30 minutes of taking it that lasted throughout the day.The compound lifted my mood, providing me with the right frame of mind to easily accomplish whatever work I had on the agenda each day.Staying active has become a
- [It’s Never Too Late: Taking Anti-Aging Compounds Early or Late in Life Thwarts Physical Decline and Heart Aging, Study Shows](https://www.nmn.com/news/its-never-too-late-taking-anti-aging-compounds-early-or-late-in-life-thwarts-physical-decline-and-heart-aging-study-shows) - Highlights: Regardless of whether treatment started early in life (similar to a 25-year-old human) or later (similar to a 52-year-old human), by 22 months of age (similar to a 65-year-old human), all mice treated with acarbose or rapamycin saw enhancement in motor function, endurance capacity, and coordination.Early or late-life treatment with acarbose or rapamycin mitigates
- [Plant-Based Substance Reduces Age-Related Muscle Weakness in Mice, Study Reveals](https://www.nmn.com/news/plant-based-substance-reduces-age-related-muscle-weakness-in-mice-study-reveals) - Highlights: Administration of farnesol prevented muscle weakness and metabolic misregulation in aged mice.Farnesol treatment also enhanced muscle “stem cell” growth and regenerative capacity.These results suggest that farnesol might prevent muscle weakness related to aging or disease conditions. Giving old mice a natural compound called farnesol, found in Japanese honeysuckle and other plants, made their muscles
- [Preliminary Findings from Clinical Trial Confirm Senolytic Therapy’s Safety for Alzheimer’s](https://www.nmn.com/news/preliminary-findings-from-clinical-trial-confirm-senolytic-therapys-safety-for-alzheimers) - Highlights: This 12-week trial tested intermittent senolytic therapy on 5 participants with early-stage symptomatic Alzheimer’s.The study supports the safety and tolerability of senolytic combo dasatinib and quercetin in older adults with Alzheimer’sWhile the study was not meant to test for efficacy, the results suggest that senolytic treatment can affect senescence biomarkers in the cerebrospinal fluid
- [Dr. Peter Attia’s Longevity Secrets: The Supplements He Takes and How to Know if They Work](https://www.nmn.com/news/dr-peter-attias-longevity-secrets-the-supplements-he-takes-and-how-to-know-if-they-work) - According to a recent podcast, Attia’s daily supplement stack is as follows: Morning: EPA and DHA fish oil: 2.5 g and 1 g Vitamin D3: 5000 IU Magnesium: 1 g Vitamin B9: 400 mcgVitamin B12: 500 mcg Vitmagin B6 (3x per week): 50 mg Asprin: 81 mg Pendulum Glucose Control probioticAG1 multi-supplement powder Night: Ashwagandha: 600 mg Glycine: 2 gMagnesium Phosphatidylserine (to overcome jetlag): 400 mg
- [Eating Strawberries Boost Memory and Wards Off Depression, Study Shows](https://www.nmn.com/news/eating-strawberries-boost-memory-and-wards-off-depression-study-shows) - Highlights: Supplementing with strawberry powder improves the cognitive performance of overweight, middle-aged individuals. Strawberry powder reduces symptoms of depression in overweight, middle-aged individuals. It is becoming increasingly clear that obesity is a key factor in driving neurodegenerative disorders like Alzheimer’s disease and Parkinson’s disease. This is because obesity leads to chronic inflammation, which gradually damages the
- [Columbia University Study Reveals 8 Lifestyle Habits Associated with Slowing Biological Age](https://www.nmn.com/news/columbia-university-study-reveals-8-lifestyle-habits-associated-with-slowing-biological-age) - Highlights: Following the American Heart Association’s 8 lifestyle habits for improving heart health is correlated with slower aging. These 8 lifestyle habits are eating better, being more active, not smoking tobacco, getting enough sleep, managing weight, controlling cholesterol, managing blood sugar, and managing blood pressure. Findings presented at this year’s American Heart Association’s (AHA’s) annual conference
- [From Nature to Medicine: Study Shows Root Extract Revitalizes Stem Cells and Enhances Tendon Repair in Old Age](https://www.nmn.com/news/from-nature-to-medicine-study-shows-root-extract-revitalizes-stem-cells-and-enhances-tendon-repair-in-old-age) - Highlights: Treating aged tendon stem cells with POG reduces cellular senescence – a dysfunctional state where cells cease to grow and divide – and boosts their function (stemness). Orally supplementing injured aged (18-month-old) rats with POG enhances tendon regeneration and reduces markers of senescence and inflammation. Our ability to bounce back from tendon injuries falters with
- [Researchers Unveil “Anti-aging” Vaccine in Mice](https://www.nmn.com/news/researchers-unveil-anti-aging-vaccine-in-mice) - Highlights A cell surface molecule called Gpnmb is enriched in specific senescent cells in humans and mice.Deletion of Gpnmb-positive cells improved systemic metabolic abnormalities and reduced atherosclerosis in mice fed a high-fat diet. Senolytic vaccination also improved typical and disease-like characteristics associated with aging and extended the male lifespan of mice with an accelerated aging
- [Cutting-Edge Magnetically Guided Senolytic Technology Eliminates Blood Vessel Plaques in Latest Study](https://www.nmn.com/news/cutting-edge-magnetically-guided-senolytic-nanoparticles-eliminate-blood-vessel-plaques-in-latest-study) - Highlights Researchers magnetically guided senolytic vesicles to the largest artery — the aorta — to clear plaques in mice with cardiovascular disease.The senolytic vesicles were able to decrease the total number of senescent cells — dysfunctional cells that emit inflammatory molecules — in the aorta. Atherosclerosis is the thickening and hardening of blood vessels from
- [Harvard's David Sinclair Reveals His Daily Diet and Lifespan-Promoting Habits](https://www.nmn.com/news/nmn-researcher-and-harvard-professor-david-sinclair-shares-his-daily-diet-and-health-promoting-habits) - Highlights Dr. Sinclair gets at least six hours of sleep per night, preferring seven to eight hours, and sleeps on a bed that lowers his body temperature during the night.Sinclair rinses his mouth with coconut oil every morning to improve his mouth’s microbial composition.Sinclair eats a bit of yogurt mixed with plant-derived polyphenolic molecules like
- [Harvard Scientist David Sinclair Confirms NMN’s Life Extending Efficacy](https://www.nmn.com/news/harvard-scientist-david-sinclair-legitimizes-nmns-life-extending-efficacy) - Highlights: In his latest chats with the media, Sinclair teased some yet-to-be-released findings: NMN is looking like a life-extender for mice. Mouse longevity studies are basically our crystal ball for human aging. Meet the All-Stars of anti-aging: rapamycin, acarbose, captopril, and glycine. David Sinclair, a pioneering researcher from Harvard Medical School, is neck-deep in the
- [Why YouTuber Dr. Brad Stanfield No Longer Takes NMN and the NAD+ Precursor He Takes Instead](https://www.nmn.com/news/why-youtuber-dr-brad-stanfield-no-longer-takes-nmn-and-the-nad-precursor-he-takes-instead) - Highlights: Instead of taking NMN or NR, Stanfield takes 50 mg of niacin, gets regular exercise, eats well, and gets sufficient sleep.The science says exercise, caloric restriction, eating and avoiding certain foods, and sleeping well help to maintain NAD+ levels. There are more human studies supporting the anti-aging effects of NMN than niacin, so Stanfield’s reasoning
- [Who Takes NMN and Should You?](https://www.nmn.com/news/who-takes-nmn-and-should-you) - Highlights Those aged 35 and above who take NMN proactively seek NAD+ restoration to promote health, prevent aging, and improve physical function.Others above age 65 taking NMN do so to stave off frailty — the loss of physical functioning capacity — and enhance metabolism. The compound NMN has fallen under aging researchers’ radar in recent
- [Plant-Based Senolytic Flavonoids Are Linked to Slower Aging: New Study](https://www.nmn.com/news/dietary-fruit-and-vegetable-based-flavonoid-intake-is-associated-with-decelerated-physiological-aging-new-study) - Highlights High flavonoid content diets for those who don’t smoke or drink high levels of alcohol tend to confer lower blood marker-based biological age readings compared to chronological age: -1.10 years for the whole body, -1.68 years for the heart, and -4.69 years for the liver.A high flavonoid diet is more likely to slow aging
- [New Study Unveils NMN's Potential to Enhance Stem Cell Therapy](https://www.nmn.com/news/new-study-unveils-nmns-potential-to-rejuvenate-stem-cells-for-stem-cell-therapy-enhancement) - Highlights: NMN enhances the ability of stem cells to migrate, suggesting they can better target damaged tissues once injected into the body. Stem cells are hindered by excessive levels of reactive oxygen species (ROS), which NMN diminishes. NMN prevents stem cells from entering a dysfunctional pro-inflammatory state called senescence. Stem cells are now being implemented in the
- [Eat Your Way to a Sharper Mind: Study Shows Omega-3 DHA Can Reverse Brain Defects from Junk Food](https://www.nmn.com/news/eat-your-way-to-a-sharper-mind-omega-3-dha-can-reverse-damage-from-junk-food-diets) - Highlights: Aged rats fed a high-fat diet (HFD) show deficits in learning and memory that are improved by DHA. Brain insulin resistance — a prerequisite to diabetes — is reduced by DHA.DHA reduces brain oxidative stress and inflammation. While delicious, a lifetime of consuming an American-style diet, consisting of high-fat and high-sugar foods leads to age-related diseases like
- [University of Pittsburgh Finds Stem Cell-Secreted Particles That Can Restore Cognitive Function in Old Age](https://www.nmn.com/news/tiny-particles-secreted-from-stem-cells-restore-cognitive-function-university-of-pittsburgh-study-reveals) - Highlights: Injecting aged mice with young mouse serum containing extracellular vesicles ameliorates memory impairment. Removing EVs from young mouse serum reverses the serum’s cognitive-boosting effects. Treatment with EVs increases the activity of several genes involved in neuroprotection. Extracellular vesicles (EVs) have gained prominence in the field of neuroprotection due to their emerging roles as critical intercellular communicators
- [New Study Shows Plum Juice Prevents High Blood Pressure and Reverses Blood Vessel Aging](https://www.nmn.com/news/study-reveals-japanese-plum-juice-as-remedy-for-preventing-high-blood-pressure-and-reversing-blood-vessel-aging) - Highlights: Drinking bainiku-ekisu (BE) prevents abnormally high blood pressure in hypertensive mice. BE prevents blood vessel wall collagen buildup, an indicator of blood vessel deterioration and cardiovascular disease progression. Treatment with BE prevents blood vessel wall immune cell infiltration, which promotes inflammation and also contributes to cardiovascular disease progression. Hypertension is a major risk factor for cardiovascular
- [Scientists Use Seaweed Molecule to Boost Memory and Increase Brain  Cells](https://www.nmn.com/news/scientists-boost-memory-and-reduce-brain-inflammation-with-seaweed-derived-fucoidan) - Highlights: Fucoidan boosts the memory of mice modeling inflammation-induced brain aging. An inflammatory protein associated with cognitive decline called IL-1β is reduced by fucoidan. Injection of fucoidan also promotes the production of neurons, suggesting it protects against brain damage. A therapy to effectively slow the cognitive decline associated with brain aging has yet to be established. Still,
- [Taking Curcumin and Vitamin E Curbs Diabetes-Related Infertility](https://www.nmn.com/news/taking-curcumin-and-vitamin-e-curbs-diabetes-related-infertility) - Highlights: Male diabetic rats exhibit multiple reproductive deficiencies, including reduced sperm count, decreased motility, decreased viability, and lower testosterone.Treatment with curcumin and vitamin E ameliorates reproductive deficits in male diabetic rats. Treatment lowers oxidative stress levels and the amount of DNA damage in sperm cells. Males with diabetes are often susceptible to several physiological abnormalities, one
- [Old Mice That Exchange Blood with Young Mice Have Lower Biological Age and Live Longer, Harvard and Duke Study Shows](https://www.nmn.com/news/old-mice-that-exchange-blood-with-young-mice-have-lower-biological-age-and-live-longer-harvard-and-duke-study-shows) - Highlights: For the first time, researchers have demonstrated that exposure to the young circulatory system leads to persistent and systemic slowing of epigenetic aging.Notably, this effect correlates with a longer life span and improved physical characteristics.While this approach may not be feasible in humans, the analyses methods and insights could translate to the development of
- [Revitalizing Muscle Mass During Aging with Combined Pea Protein and Plant Fiber Inulin: French Study](https://www.nmn.com/news/revitalizing-muscle-mass-during-aging-with-combined-pea-protein-and-plant-fiber-inulin-french-study) - Highlights Pea protein combined with inulin increases the mass of fast-twitch muscle — used for quick bursts of movement — in aged rats.The nutrient combination of pea protein with inulin reduces gene activity for the MuRF1 protein involved in muscle breakdown.The nutrient combination enhances fast-twitch muscle mitochondrial enzymes with key roles in cell energy generation.
- [NMN Sales Continue After FDA Refuses Public Hearing](https://www.nmn.com/news/despite-fdas-supplement-objection-is-nmn-permitted-in-foods) - Highlights: The FDA denied a congressman’s request for a public hearing concerning the FDA’s actions regarding NMN on grounds of public interest.NMN could be sold as a food additive because it has generally recognized as safe (GRAS) status.Because NMN is already considered safe and effective, the FDA is hurting consumers by not allowing for the
- [EGCG and Curcumin Combo Reverses Cognitive Decline: New Findings](https://www.nmn.com/news/synergistic-restoration-of-cognitive-decline-by-egcg-and-curcumin-antioxidant-combo-recent-findings) - Highlights Mouse models for aging exhibit memory impairments, yet the combination of epigallocatechin 3 gallate (EGCG) and curcumin restores youthful cognition.The combination of EGCG and curcumin reverses the age-associated decline of neuronal antioxidant enzymes glutathione (GSH) and superoxide dismutase (SOD).EGCG and curcumin combined blunt age-associated neuronal stress from highly reactive, oxygen-containing molecules (reactive oxygen species
- [Is Life Extension Expert Dr. Peter Attia Right About the Approach to an NMN Study Needing Improvement?](https://www.nmn.com/news/is-life-extension-expert-dr-peter-attia-right-about-an-nmn-clinical-trial-being-smoke-and-mirrors) - Highlights: Attia has no gripes about the study in question’s results showing NMN elevates NAD+ levels.He says the method used to measure biological age is not reliable. The physical performance assessment doesn’t actually measure physical performance and has no clinical significance, says Attia. Licensed physician Peter Attia is the author of the #1 New York Times
- [New Study Reveals Sea Cucumber Peptides Strongly Protect Against Cognitive Impairment](https://www.nmn.com/news/new-study-reveals-sea-cucumber-peptides-strongly-protect-against-cognitive-impairment) - Highlights: Treating cognitively impaired mice with sea cucumber peptides (SCP) enhances memory in a dose-dependent manner. SCP protects against neuronal damage and improves synapse plasticity. Aging is closely intertwined with cognitive impairment, as the passage of time can introduce unwarranted changes in learning and memory capabilities. Aging researchers are continuously looking for natural compounds capable of
- [German Scientists Successfully Repurpose Common Vertigo Drug to Treat Cognitive Impairment](https://www.nmn.com/news/german-scientists-successfully-repurpose-common-vertigo-drug-to-treat-cognitive-impairment) - Highlights: Vertigoheel improves visual, spatial, and olfactory memory in aged rats and cognitively impaired mice. Treatment with vertigoheel stimulates the branching of neurons, which ehances brain connectivty. Humans become increasingly susceptible to cognitive impairment (CI) with age, eventually facing difficulties with memory, attention, reasoning, and problem-solving skills. To date, limited therapies for CI exist, as the
- [New Study Reveals Metformin’s Profound Ability to Enhance Bone Fracture Healing](https://www.nmn.com/news/new-study-reveals-metformins-profound-ability-to-enhance-bone-fracture-healing) - Highlights: Metformin speeds up bone fracture healing in mice modeling osteoporosis – a prevalent bone disorder characterized by reduced bone density and increased fracture risk. Metformin’s protective effects likely stem from its ability to increase the formation of blood vessels, which are vital to bone fracture healing. Afflicting nearly 33% of women and 20% of men
- [Stem Cell Secreted Vesicles Counteract Aging: Latest Study](https://www.nmn.com/news/vesicles-secreted-from-stem-cells-counteract-signs-of-aging-latest-study) - Highlights EV treatment reduces cellular senescence and restores cellular proliferative capabilities.Two short snippets of RNA called microRNAs (miRNAs) within the extracellular vesicles — miR-15b-5p and miR-290a-5p — rejuvenate aged cells when transfected into them.Treating mice with stem cell-derived EVs reduces levels of proteins linked to senescence in multiple organs, including the liver, kidney, and spleen.
- [New Drug Combo Counters Muscle Aging and Enhances Physical Fitness, Italian Study Shows](https://www.nmn.com/news/italian-study-shows-new-drug-combo-counters-muscle-aging-and-enhances-physical-fitness) - Highlights: Treatment with a combination of metformin and galantamine called RJx-01 enhances physical performance and strength while reducing inflammation and denervation – detachment of the nerve from muscle cells in aged mice. RJx-01 restores autophagy – the removal of cellular waste – and replenishes stem cells in aged mice. Susceptibility to the progressive loss of muscle
- [University of Washington: Natural Molecule Counteracts Learning and Memory Deficits Induced by Sleep Deprivation](https://www.nmn.com/news/university-of-washington-natural-molecule-counteracts-sleep-deprivations-impact-on-learning-and-memory) - Highlights: Injecting sleep-deprived mice with GHK prevents impairments in learning and memory. GHK prevents inflammation in the hippocampus — the brain's memory-consolidating region. Oxidative stress — damage caused to cells by excessive oxidant molecules — is prevented by GHK injections. In many ways, sleep deprivation accelerates the aging process. Like aging, sleep deprivation increases the risk of several high-mortality
- [New Study Shows Senomorphic Flavonoids Boost Cancer Treatment Efficacy](https://www.nmn.com/news/the-powerful-senomorphic-rutin-amplifies-cancer-treatment-efficacy-study-finds) - Highlights: In vitro, rutin successfully decreases the activity of the senescence-associated secretory phenotype (SASP) – compounds secreted by senescent cells that drive inflammation and support tumor growth. Combining rutin with the chemotherapeutic drug MIT is more successful at reducing tumor size than treatment with MIT alone. The older we get, the more senescent (aged) cells accumulate
- [Nature’s Shield: Plant Extract Protects the Heart During Chemotherapy, Study Finds](https://www.nmn.com/news/natures-shield-plant-extract-protects-the-heart-during-chemotherapy-study-finds) - Highlights: BrE mitigates heart shrinking and preservers cardiac structural integrity in rats receiving doxorubicin (DOX), a common chemotherapeutic drug known to damage the heart. Rats treated with BrE exhibit significantly lower levels of inflammation and oxidative stress. Curtailing the destructive effects of cancer often requires patients to undergo chemotherapy, a standard treatment for extinguishing cancerous cells.
- [Scientists Find Muscle-Building Supplement Improves Learning and Memory in Alzheimer's](https://www.nmn.com/news/scientists-find-muscle-building-supplement-improves-learning-and-memory) - Highlights: Oral supplementation with HMB restores the learning and memory of Alzheimer’s model mice. HMB prevents the loss of neuron outgrowths called dendritic spines, important for connecting neurons. Treatment with HMB enhances the electrical signaling responsible for strengthening neuronal connections, critical for memory formation. Recently, a drug developed by Biogen called lecanemab was approved by the FDA
- [New Study: A Single High-Intensity Exercise Session Increases NMN and Counteracts Chemotherapy-Induced Heart Injury](https://www.nmn.com/news/new-study-a-single-high-intensity-exercise-session-increases-nmn-and-counteracts-chemotherapy-induced-heart-injury) - Highlights An intensive round of exercise preserves cardiac function against treatment with the chemotherapeutic agent doxorubicin.Nicotinamide mononucleotide (NMN) and nicotinamide adenine dinucleotide (NAD+) levels fall in the heart following doxorubicin treatment, but high-intensity exercise prior to treatment preserves their levels.Sufficient NAD+ is essential for generating cell energy, and intensive exercise preserves cell energy production against
- [Harvard's David Sinclair Unveils Age-Reversing Small Molecule Cocktails that Rejuvenate Cells](https://www.nmn.com/news/innovative-research-harvard-scientists-unveil-age-reversing-cocktails-that-rejuvenate-cells) - Highlights Sinclair and colleagues show that six chemical combinations reverse cellular age within a week of applying them.Using gene activity-based aging clocks (RNA-seq technology), Sinclair and colleagues confirm the cells’ age reversal after treatment with the chemical combinations.The cells don’t exhibit signs of turning to stem cells, which could potentially trigger cancer in living tissue.
- [One-Time Injection Enhances Brain Function In Monkeys](https://www.nmn.com/news/one-time-injection-enhances-brain-function-in-monkeys) - Highlights: The non-human primate form of klotho is stable, safe, and increases blood levels of klotho protein in aged rhesus macaques.A single, low-dose injection of klotho enhances cognition in aged rhesus macaques in as little as 4 hours and lasts two weeks.This work suggests that a systemic low-dose klotho treatment may prove therapeutic in aging
- [Scottish Scientists Determine How Much Food to Eat for Prolonging Lifespan](https://www.nmn.com/news/scottish-scientists-determine-how-much-food-to-eat-for-prolonging-lifespan) - Highlights: A caloric deficit of 20%, 30%, or 40% increasingly raises survival rates, attributed largely to slowing the progression of cancer. On average, a calorically restricted diet leads to the stabilization of body weight after 30 days. Losses in fat and fat-free mass (muscle, bone, & other organs) increase as calories are reduced. From yeast to mice,
- [Cornell Researchers Show Unequal Distribution of NAD+ Across Organs Following NMN Administration](https://www.nmn.com/news/cornell-researchers-reveal-unequal-distribution-of-nad-across-organs-following-nmn-administration) - Highlights: Without NMN, NAD+ levels are highest in the kidney and liver of young mice and lowest in blood and fat tissue.NMN, administered either orally or injected, raises liver NAD+ levels more than in other tissues. The majority of NMN is converted to other NAD+ precursors (i.e. nicotinamide or nicotinamide riboside [NR]) before being converted to
- [Researchers Reveal that Creatine Enhances Memory](https://www.nmn.com/news/researchers-reveal-that-creatine-enhances-memory) - Highlights: Creatine treatment improved memory as compared to placebo across 10 studies worldwide.Subgroup analysis showed that memory improvement was more significant in seniors than in younger individuals.Treatment duration and gender did not influence the results. Creatine is often used as a supplement either shortly before or immediately after exercise to help increase strength and improve
- [Japanese Study Suggests Ideal Protein Intake Ratio for Metabolic Health and Longevity](https://www.nmn.com/news/japanese-study-suggests-ideal-protein-intake-ratio-for-metabolic-health-and-longevity) - Highlights: A protein intake of 25% (percentage of total calories) or higher reduces liver fat deposition in middle-aged mice. Intake levels of 35% or higher reduce blood glucose levels. Protein intake levels of 45% increase circulating free fatty acid levels, an indicator of poor metabolic health. Low-protein diets have been found to increase the lifespan of rodents,
- [Selenium and Coenzyme Q10 Counter Telomere Shortening, Potentially Prolonging Lifespan: Scandinavian Clinical Trial](https://www.nmn.com/news/selenium-and-coenzyme-q10-counter-telomere-shortening-potentially-prolonging-lifespan-scandinavian-clinical-trial) - Highlights: Supplementation with selenium and coenzyme Q10 (Se + Q10) prevents telomere — repetitive DNA sequences at the ends of chromosomes — shortening in older adults with low selenium levels. Despite Se + Q10 supplementation, shorter telomeres are associated with cardiovascular-related death. Those with the longest telomeres have a higher survival rate than those with shorter telomeres. It
- [Taking Probiotics Could Have Similar Effects as Fecal Matter Transplant in Treating Aging](https://www.nmn.com/news/taking-probiotics-could-have-similar-effects-as-fecal-matter-transplant-in-treating-aging) - Highlights: Old mice treated with fecal microbiota transplantations (FMT) from mice had improved sugar tolerance, inflammation, and intestinal barrier.Treating old mice with A.muciniphila – a bacteria which increases with FMT and is normally decreased in old mice – had results similar to FMTfrom young mice.Both A.muciniphila and FMT increase acetic acid in the intestines and
- [Latest Study Shows Berberine's Powerful Potential to Boost Liver Health](https://www.nmn.com/news/berberine-a-promising-restorative-agent-for-liver-fat-metabolism-and-disease-alleviation-latest-study-findings) - Highlights Berberine reverses liver triglyceride elevations and lowers enzyme markers for liver disease (alanine transaminase [ALT] and aspartate transaminase [AST]) in a high fat diet-induced liver disease mouse model.Lower levels of the pro-longevity protein sirtuin 1 (SIRT1) were found in liver disease patients, yet berberine increased SIRT1 levels in the liver disease mouse model.SIRT1 improves
- [New Study Demonstrates Plant-Derived Molecule Berberine's Potential to Inhibit Cancer Cell Growth](https://www.nmn.com/news/new-study-reveals-plant-derived-molecule-berberine-powerfully-halts-cancer-cell-growth) - Highlights Berberine dramatically reduces the viability of human colorectal cancer cells in laboratory dishes.The plant-derived molecule halts cancer cell proliferation by inducing apoptosis.Berberine substantially limits human colorectal cancer cell migration, an indication that it inhibits the spread of cancer. Colorectal cancer is one of the most common cancer types, ranking as the fourth most common
- [Pterostilbene Prevents Diabetes-Induced Memory Loss and Brain Degeneration in New Study](https://www.nmn.com/news/plant-based-pterostilbene-prevents-diabetes-induced-memory-loss-and-brain-degeneration-chinese-study) - Highlights: Pterostilbene, but not metformin (anti-diabetes drug) prevents memory impairments and neurodegeneration in a mouse model for diabetic cognitive impairment. Treatment with pterostilbene lowers blood glucose levels as effectively as metformin. Pterostilbene reduces inflammation in the brain and the gut. Our bodies can only handle so much sugar, the carbohydrate initially impossible to find in its modern
- [Study Shows Bacteria Found in Centenarians can Lead to Increased Healthspan](https://www.nmn.com/news/study-shows-bacteria-found-in-centenarians-can-lead-to-increased-healthspan) - Highlights: The centenarians of Guangxi, China have increased diversity within their gut microbiota as compared to younger elderly people.A probiotic complex made of two strains of bacteria found in the Guangxi centenarians led to benefits in naturally aging mice, including greater mobility and decreased anxiety.The treated naturally-aged mice also had decreased oxidative stress, increased antioxidant
- [2023’s Hot Longevity Supplements: NMN, NR, Resveratrol, Berberine, Quercetin, & Curcumin](https://www.nmn.com/news/2023s-hot-longevity-supplements-nmn-nr-resveratrol-berberine-quercetin-curcumin) - Highlights: These longevity-linked compounds target the underlying cellular causes of aging, including oxidative stress, inflammation, DNA damage, and cellular senescence. Targeting these hallmarks of aging has led to the protection against several age-related diseases known to shorten lifespan. In the realm of aging research, significant advancements have brought forth molecules with the potential to extend lifespan
- [New Study: Olive Leaf Extract Could Counter Muscle Aging by Boosting Mitochondria](https://www.nmn.com/news/new-study-reveals-olive-leaf-extract-could-counter-muscle-aging-by-boosting-mitochondria) - Highlights: Muscle samples from older donors show calcium-related mitochondrial defects that correlate with low muscle mass and strength. Dietary olive leaf extract improves mitochondrial function, running time, and muscle weight in aged mice. Our mitochondria produce the energy needed to sustain life. This is why mitochondrial dysfunction is a hallmark of aging, contributing to chronic diseases
- [Longevity-Promoting Organization Calls for Accelerating FDA Approval of Longevity Medicines](https://www.nmn.com/news/longevity-promoting-organization-calls-for-accelerating-fda-approval-of-longevity-medicines) - Highlights: The current economic turmoil in the U.S. may be exacerbated by the rising aging population if something is not done soon.Public perception must align with current advances in aging science which points to targeting multiple chronic diseases with a single drug.A4LI proposes the FDA aligns its definitions of chronic disease and aging with the
- [Researchers Discover The Natural Compound Berberine Could Treat Stroke Damage](https://www.nmn.com/news/researchers-discover-the-natural-compound-berberine-could-treat-stroke-damage) - Highlights: Treating a mouse model for intracerebral hemorrhage (ICH) – a stroke subtype– with berberine reduces brain inflammation (neuroinflammation) and enhances neurological function. Abolishing healthy gut microbiota - trillions of diverse microorganisms key to gut health - in ICH mice eliminates berberine’s neuroprotective effects. Nearly 20% of all strokes are caused by an intracerebral hemorrhage (ICH),
- [Scientists Discover Plant Compound Exerts Anti-aging Senolytic Effects](https://www.nmn.com/news/scientists-discover-plant-compound-exerts-anti-aging-senolytic-effects) - Highlights: Cycloastragenol eliminates cultured senescent human cells without affecting non-senescent cells.Proteins involved in cell survival and growth were decreased in senescent cells treated with cycloastragenol.Radiation-induced aged mice showed reversed signs of aging when treated with cycloastragenol, including better motor skills and reduced senescent cells. Aging is an inevitable part of life; however, researchers are working
- [Scientists Link Inflammation and Repeated Infections to Reduced Intelligence](https://www.nmn.com/news/scientists-link-inflammation-and-repeated-infections-to-reduced-intelligence) - Highlights: Middle-aged mice given repeated bacterial exposures (infections) have decreased memory retention during maze tests.Repeated infections lead to inflammation in the hippocampus, part of the brain which is primarily responsible for learning and memory formation.Inflammation in the hippocampus leads to decreased communication between nerve cells (neurons) and reduced memory retention. Age-related cognitive decline is a
- [Researchers Find Low-Carb Ketogenic Diet Can Reduce Lifespan in Mice](https://www.nmn.com/news/researchers-find-low-carb-ketogenic-diet-can-reduce-lifespan-in-mice) - Highlights: Genetically altered mice lacking ketogenesis have shortened lifespans.Middle-aged and old mice fed a low-carb ketogenic diet exhibit higher mortality.Supplementing the regular diets of old mice with a solvent for flavoring agents (1,3-butanediol) improves survival. Interest in the keto diet has skyrocketed in recent years, with consumer products bearing the label taking over grocery shelves.
- [Brain-Boosting Ketogenic Diet Wards Off Memory Loss and Anxiety: UC Davis Study](https://www.nmn.com/news/brain-boosting-ketogenic-diet-wards-off-memory-loss-and-anxiety-uc-davis-study) - Highlights: Mice on a standard diet show a decline in memory with age while mice on the ketogenic diet stay sharp. The ketogenic diet prevents age-related anxiety-like behavior and increases isometric (without joint movement) strength.Inflammation drops and “good” HDL cholesterol rises with the ketogenic diet. Our cells are naturally adapted to using glucose (from carbohydrates) as
- [Israeli Study Shows Three-Fold Improvement in Reducing Blood Vessel Hardening with New Green Mediterranean Diet](https://www.nmn.com/news/israeli-study-shows-three-fold-improvement-in-reducing-blood-vessel-hardening-with-new-green-mediterranean-diet) - Highlights: Combined with physical activity, the hypocaloric Green Mediterranean diet reduces artery stiffness by 15% while a standard healthy diet reduces it by 4.8%. The physical activity protocol includes aerobic, and resistance (weight lifting) exercises. The Green Mediterranean diet includes foods high in polyphenols — plant-based molecules encompassing senolytics like quercetin. The hardening of our arteries —
- [Latest Study: Repurposed Drugs Prevent Cognitive Decline in Alzheimer’s Disease Model](https://www.nmn.com/news/latest-study-repurposed-drugs-reduce-sticky-ab-protein-deposits-and-prevent-cognitive-decline-in-alzheimers-disease-model) - Highlights Two already FDA-approved drugs, acetazolamide and methazolamide, show a statistical trend toward preventing cognitive decline in an Alzheimer’s disease mouse model.The two drugs remove sticky proteins contributing to Alzheimer’s disease in the brain vasculature of Alzheimer’s disease mice.Acetazolamide and methazolamide suppress a key enzyme found to have elevated levels in human Alzheimer’s patients’ mitochondria
- [Study Shows Reishi Fungus Increases Testosterone and Prevents Male Reproductive Aging](https://www.nmn.com/news/china-study-suggests-reishi-fungus-increases-testosterone-and-prevents-male-reproductive-aging) - Highlights GL extract consumption increased testosterone levels ~25% in middle-aged male mice. Supplementing with GL extract more than doubled the number of times middle-aged male mice pursued females, an indicator of enhanced sexual function and libido. Middle-aged male mice that consumed GL extract produced about 37% more offspring than those that didn’t ingest the fungus.
- [New Study Shows Rapamycin Restores Blood Flow to Aging Limbs](https://www.nmn.com/news/scientists-successfully-restore-blood-flow-to-limbs-affected-by-alzheimers-and-atherosclerosis-with-rapamycin) - Highlights: Feeding aged mice rapamycin increases their blood flow to reach that of young mice. In a mouse model for atherosclerosis — a disease involving hardening of the arteries, rapamycin treatment restores blood flow. Alzheimer’s model mice also see an increase in blood flow from treatment with rapamycin. A lesser-known age-related disease with dire consequences called peripheral artery
- [Study by the American Nutrition Association Shows a DNA-Targeting Diet Combined with Exercise Can Reverse Biological Age in Women](https://www.nmn.com/news/american-nutrition-association-study-diet-targeting-dna-along-with-exercise-reverses-womens-biological-age) - Highlights Biological age reductions ranged from 1.22 and 11.01 years in five out of six participants with an average decline of 4.60 years after eight weeks of the program. The study’s dietary program included the consumption of foods that promote DNA methylation, including rosemary, turmeric, and green tea. The study participants’ exercise prescription entailed 60%
- [Longevity Expert Dr. Lamming Discusses How Fasting Drives Metabolic & Aging Benefits in Mice](https://www.nmn.com/news/dr-lamming-on-fasting-not-merely-counting-calories-driving-metabolic-aging-benefits-in-mice) - NMN.com · Dr. Lamming on Fasting, Not Merely Counting Calories, Driving Metabolic & Aging Benefits in Mice Welcome to the NMN.com podcast! I'm your host Brett Weiss. And today we have professor Dudley Lamming from the University of Wisconsin School of Medicine who will talk about his most recent study published in Nature Metabolism. His
- [An Aging Population May Not Spell Catastrophe for the US Economy](https://www.nmn.com/news/an-aging-population-may-not-spell-catastrophe-for-the-us-economy) - Highlights According to the US Census Bureau, about a quarter of the US population will be of retirement age by 2060 — up from 15% in 2016 — which may spur a forecasted 5.5% dip in the gross domestic product (GDP). An aging population also drives lower labor force participation — the percentage of adults
- [German Study Finds Eating Strawberries and Capers Lowers Cholesterol and Inflammation](https://www.nmn.com/news/german-study-finds-eating-strawberries-and-capers-lowers-cholesterol-and-inflammation) - Highlights: Strawberries and capers contain high levels of senolytics — compounds that eliminate age-promoting (senescent) cells. Older individuals who consumed copious amounts of strawberries and capers saw a reduction in low-density lipoprotein (LDL) cholesterol after ten weeks. Ten weeks of the senolytic-containing diet also reduced the pro-inflammatory marker IL-6, among other benefits. “Fruits and vegetables are good
- [Breakthrough in Heart Attack Recovery: Scientists Fine-Tune Cell Reprogramming Technology](https://www.nmn.com/news/breakthrough-in-heart-attack-recovery-scientists-fine-tune-cell-reprogramming-technology) - Highlights: Human skin cells are more efficiently reprogrammed to become heart cells by blocking four specific genes, abbreviated AJSZ, with RNA interference. Blocking AJSZ combined with cell reprogramming reduces heart tissue scarring following heart attack in mice. Blocking AJSZ with cellular reprogramming improves heart function after heart attack by 50% more than normal cellular reprogramming. Groundbreaking studies
- [Antioxidant ɑ-Ketoglutarate Revitalizes Cartilage Cells and Promotes Joint Health in Arthritis: China Study](https://www.nmn.com/news/antioxidant-ketoglutarate-revitalizes-cartilage-cells-and-promotes-joint-health-in-arthritis-china-study) - Highlights Ɑ-ketoglutarate (AKG) reverses inflammation-induced stunted human cartilage cell growth. AKG supplementation restores cartilage formation in an arthritis rat model. AKG improves cartilage mitochondrial health by revamping gene activity for degradation of defective mitochondria (mitophagy) in arthritic rats. Arthritis (osteoarthritis) affects over 32.5 million adults in the US and is characterized by severe joint pain
- [Antioxidant PQQ Shows Little Effect on Brain Function in Adults: Latest Human Trial](https://www.nmn.com/news/antioxidant-pqq-enhances-brain-function-in-younger-and-older-adults-latest-human-trial) - Highlights Supplementing with PQQ for 12 weeks slightly improves complex and verbal memory in older adults.PQQ mildly enhances the ability to respond to changes in instructions and to understand and make decisions about rules and concepts, both cognitive parameters, in younger adults. PQQ is a vitamin-like compound found in soil and various foods like spinach,
- [Study Shows NMN Enhances Stem Cell Vesicle Therapy for Heart Attack Damage](https://www.nmn.com/news/chinese-study-shows-nmn-enhances-new-potential-therapy-for-heart-attack-damage) - Highlights: Vesicles secreted from stem cells treated with NMN (N-Vs) improve heart function in rats following heart attack. N-Vs promote blood vessel formation, namely small arteries and capillaries, after heart attack. Heart tissue recovery is enhanced by N-Vs following heart attack, as shown by reduced heart cell death and tissue scarring. Heart attacks account for 80% of
- [Study Shows Orchid Compound  Helps to Alleviate Osteoarthritis and Cell Aging](https://www.nmn.com/news/study-shows-orchid-compound-helps-to-alleviate-osteoarthritis-and-cell-aging) - Highlights: Dendrobine decreases osteoarthritis progression and improves bone structure parameters in rats.Treating inflamed chondrocytes – cells that make cartilage – with dendrobine decreased cartilage degradation, increased cartilage production, and decreased cell senescence.The effects of dendrobine seem to work by decreasing reactive oxygen species (proinflammatory molecules) and inhibiting proinflammatory proteins. Osteoarthritis is the most common form
- [The NPA and ANH Petition the FDA Concerning NMN’s Classification as an Investigational New Drug](https://www.nmn.com/news/the-npa-and-anh-petition-the-fda-concerning-nmns-classification-as-a-drug) - The Natural Products Association (NPA) and the Alliance for Natural Health (ANH), two organizations representing the dietary supplements industry, have filed a Citizen’s Petition with the Food and Drug Administration (FDA). Their petition asks the FDA to reevaluate its position concerning the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN). As of November 2022, the
- [New Study Shows NAD+ Supplement Improves Alcohol-Induced Gut Dysfunction](https://www.nmn.com/news/new-study-shows-nad-supplement-improves-alcohol-induced-gut-dysfunction) - Highlights Excess alcohol consumption contributes to a porous intestinal lining (epithelium) mediated by sealant protein (tight junction) degradation, but the NAD+ booster NR restores the lining in mice. NR increases the mitochondrial production of energy molecules (adenosine triphosphate [ATP]) in human intestinal epithelial cells treated with alcohol. NR stimulates Sirtuin1 proteins – activators of mitochondria
- [Deciphering How People Live Past 100 Years](https://www.nmn.com/news/deciphering-how-people-live-past-100-years) - While pondering the lives and times of the oldest people who’ve ever lived, a natural question that comes to mind is how exactly one can increase his/her odds of living so long. Take Jeanne Calment for example, a woman from France who purportedly lived longer than anyone ever to age 122. She lived to such
- [Spanish Study Suggests Eating Low Phosphate Foods Like Fruits and Vegetables Could  Alleviate Muscle Decline](https://www.nmn.com/news/spanish-scientists-show-dietary-phosphate-restriction-alleviates-muscle-decline) - Highlights: A low phosphate diet (LowP) but not Velphoro increases the muscle mass of aged mice. Both LowP and Velphoro increase the strength of aged mice. LowP and Velphoro improve the physical performance of aged mice. Phosphate is within every cell of our body, found most abundantly in our bones, along with the more familiar mineral calcium.
- [New Washington University Study Links Intensive Endurance Exercise to Fewer Harmful Cells in the Gut](https://www.nmn.com/news/new-washington-university-study-intensive-endurance-exercise-rids-gut-of-harmful-cells) - Highlights Intensive endurance exercise lowers gene activity for a key senescent cell protein marker – p16 – in aged runners compared to sedentary age-matched counterparts. Endurance exercise also lowers gene activity for a primary protein marker for inflammation – interleukin-6 – in aged runners compared to their sedentary peers. Higher p16 levels are linked to
- [French Study Shows Senolytics Promote Survival from Aggressive Brain Tumors](https://www.nmn.com/news/french-study-shows-removing-senescent-cells-promotes-survival-from-aggressive-brain-tumors) - Highlights: Senescent cells are present in the tumors of patients with glioblastoma — brain and spinal cord cancer of cells called glia. Removing senescent cells with the senolytic (a compound that eliminates senescent cells) ABT263 increases the lifespan of a mouse model for glioblastoma by about 30%. Senescent cells are now associated with worse overall survival for glioblastoma
- [Latest Study: The Flavonoid Luteolin Alleviates High Blood Pressure](https://www.nmn.com/news/luteolin-high-blood-pressure) - Highlights Injecting luteolin into a brain region that modulates blood pressure (paraventricular nucleus of the hypothalamus [PVN]) mitigates hypertension in rats. Luteolin injections reduce circulating adrenal hormones norepinephrine and epinephrine that can contribute to hypertension. Luteolin diminishes the number of neurons with high levels of inflammatory proteins (interleukin-1ꞵ [IL-1ꞵ]) in the PVN brain region. Nearly
- [Study Shows Compound from Citrus Fruits Protects Aging Lungs in Mice](https://www.nmn.com/news/study-shows-compound-from-citrus-fruits-protects-aging-lungs-in-mice) - Highlights: Naringin protects mouse lungs from aging with less destruction of the lung structure as compared to an induced-aging mouse model.Mice treated with naringin had less cellular stress and increased antioxidant proteins.SIRT1 increased with naringin treatments in an induced-aging mouse model. Aging is a degenerative condition,associated with failing organs and diminished organ function. The lungs
- [Anti-Aging Supplement May Rejuvenate Healthy And Osteoarthritic Human Joint Cells](https://www.nmn.com/news/anti-aging-supplement-may-rejuvenate-healthy-and-osteoarthritic-human-joint-cells) - Highlights: Dysfunction of the cell’s energy-producing centers (mitochondria) is a hallmark of joint aging and osteoarthritis.Urolithin A improves mitochondrial function in human cartilage cells from healthy donors and osteoporosis patients.In a mouse model of osteoporosis, Urolithin A improves joint mitochondrial health, reduces inflammation, and protects against osteoporosis-associated cartilage degeneration and pain. According to a study
- [Columbia University Scientists Show Anti-Inflammatory Drug Improves Blood Regeneration in Old Age](https://www.nmn.com/news/columbia-university-scientists-show-anti-inflammatory-drug-improves-blood-regeneration-in-old-age) - Highlights: Blood-producing stem cells are impaired by inflammation in old mice. Blood production and immune cell levels are dysregulated in old mice. Blocking inflammation with anakinra improves blood production and immune cell levels. Approximately one trillion cells arise from our bone marrow daily. This is because our bone marrow contains the stem cells responsible for blood production.
- [New Study: Dietary Genistein Extends Mouse Healthspan and Lifespan by 10%](https://www.nmn.com/news/new-study-dietary-genistein-extends-mouse-healthspan-and-lifespan-by-10) - Highlights: Genistein-fed mice demonstrated a 9.2% increase in maximum lifespan and a 10.0% increase in mean lifespan. Genistein decreased the incidence and severity of aging phenotypes and delayed morbidity. Microbiota from genistein-fed mice rejuvenated the aging gut and extended the lifespan of prematurely aging (progeroid) mice. Research from the China Agricultural University in Beijing showed that dietary
- [Seragon Launches Its Most Advanced Longevity Nutraceutical RESTORIN](https://www.nmn.com/news/seragon-launches-its-most-advanced-longevity-nutraceutical-restorin) - Highlights: RESTORIN is the first and only nutraceutical with patented NAD+ and senolytic technologies from both Harvard and Mayo.RESTORIN contains a repertoire of proprietary molecules to target the cellular mechanisms underlying aging processes. RESTORIN has been called “the most advanced longevity nutraceutical to date,” in part because it is the first and only such product
- [Study Shows Lion’s Mane Mushroom Enhances Memory and Reduces Brain Inflammation ](https://www.nmn.com/news/study-shows-lions-mane-mushroom-improves-memory-and-reduces-brain-inflammation) - Highlights: Aged mice supplemented with lion’s mane extract (He2) exhibit improved memory. Treatment with He2 decreases markers of inflammation and oxidative stress in the hippocampus - the brain structure responsible for learning and memory. He2 contains high concentrations of the powerful antioxidant ergothioneine (ERGO), which has been previously shown to exert neuroprotective effects. Medicinal mushrooms have taken
- [Scientists Find "Young" Gut Bacteria Revamp Immune Cells and Fortify Gut Wall](https://www.nmn.com/news/young-to-old-gut-bacteria-transfer-rejuvenates-blood-stem-cells-and-intestinal-health-shows-study) - Highlights: Transferring gut bacteria from young to old mice rejuvenates immune cells and increases mucus-secreting intestinal cells, important for protecting the intestinal wall. The Lachnospiraceae family of bacteria prevalent in young mice reduce gut leakage in old mice. The gut bacterial metabolite indole-3-carbinol (I3C) rejuvenates blood stem cells and reduces inflammation. Our stem cells are important for
- [Washington University Study Shows NMN Replenishes NAD+ in the Aging Brain](https://www.nmn.com/news/washington-university-study-shows-nmn-replenishes-nad-in-the-aging-brain) - Highlights: Scientists have developed a novel method to accurately quantify NAD+ levels in the brain, specifically in small tissues. Supplementing aged mice with NMN restores NAD+ levels in three of four hypothalamic regions. Injecting aged mice with small vesicles containing an NMN-synthesizing enzyme – NAMPT (eNAMPT) – raises NAD+ levels in four subregions of the hypothalamus. Our
- [Study Shows New “Longevity Gene” Reverses Heart and Blood Vessel Function Decline](https://www.nmn.com/news/study-shows-longevity-gene-supports-heart-and-blood-vessel-function-in-the-face-of-aging) - Highlights: Aged human hearts have lower levels of LAV-BPIFB4 longevity gene activation, along with fewer small blood vessels and more senescent (aged) cells. Treating aged human heart cells with longevity protein LAV-BPIFB4 reduces senescent cell burden. Delivering the longevity gene via gene therapy methods (AAV9) restores blood vessels and increases blood flow in the hearts of mice.
- [Probiotic Alleviates Brain Aging in New Study](https://www.nmn.com/news/probiotic-alleviates-brain-aging-in-new-study) - Highlights: Feeding age-accelerated mice Lactobacillus parcasei PS23 (PS23) improves their learning and memory. PS23 reduces anxiety-like behavior and increases the neurotransmitter serotonin. Genes involved in neuroplasticity, anti-inflammatory, and antioxidant function are increased by PS23. By the year 2030, 1 in every 6 individuals will be over the age of 60, prompting the United Nations to declare 2021-2030
- [Stanford Study Suggests Metformin Can Extend Lifespan of Seniors with Delirium and Dementia](https://www.nmn.com/news/stanford-study-suggests-metformin-reduces-delirium-and-mortality-risks-in-diabetes-patients) - Highlights Metformin use reduces the probability of delirium, which increases in prevalence with age in diabetes patients. Diabetes patients who take metformin show survival chances comparable to individuals without diabetes. In individuals with dementia and delirium, diabetes patients who took metformin have lower mortality risks than patients without diabetes. The incidence of delirium – a
- [Anti-Aging Compound Curcumin Outperforms Chemotherapy in Cancer Model: Kyoto University](https://www.nmn.com/news/anti-aging-compound-curcumin-outperforms-chemotherapy-in-cancer-model-kyoto-university) - Highlights: A drug called TBP1901 is converted to curcumin in bone marrow and is more biologically active than curcumin.TBP1901 shows significant anti-tumor effects in a mouse model for multiple myeloma – an age-related bone marrow cancer.Cancer growth in vitro (in a dish) is inhibited more by curcumin than TBP1901. Turmeric – a major source of
- [Study Shows Ketogenic Diet Prevents Sleep Deprivation-Induced Alzheimer’s](https://www.nmn.com/news/study-shows-ketogenic-diet-prevents-sleep-deprivation-induced-alzheimers) - Highlights: A ketogenic diet (KD) prevents cognitive impairments induced by sleep deprivation (SD). KD restores critical factors involved in new neuron growth and survival. SD increases brain iron content and reduces sirtuin — longevity-associated enzyme — levels, which KD prevents. As the global prevalence of Alzheimer’s disease (AD) increases, scientists have opened their minds to new potential
- [Eating Grapes Could Counter the Life-Shortening Effects of Junk Food, Suggests Study](https://www.nmn.com/news/eating-two-cups-of-grapes-daily-could-prolong-lifespan-suggests-study) - Highlights: Mice on a Western-style diet can live approximately 27% longer when fed freeze-dried grape powder. Grape supplementation decreases fat droplets in the liver, suggesting protection against non-alcoholic fatty liver disease. Antioxidant gene activation increases in response to grape supplementation. The so-called Western-style diet, consisting of high levels of refined carbohydrates and saturated fats, has consistently been
- [Probiotic Alleviates Muscle Aging  in New Study](https://www.nmn.com/news/probiotic-alleviates-muscle-aging-in-new-study) - Highlights: Treating age-accelerated mice with living or heat-killed Lactobacillus parcasei PS23 (PS23) increases grip strength and leg muscle size. Increased grip strength is correlated with increased ghrelin gene activation in the stomach. PS23 increases ghrelin in human gastric cells. Aging is closely linked to our gut bacteria, which is why scientists have been testing the effect of
- [Norwegian Study Reveals Krill Oil Protects Against Cognitive Deterioration](https://www.nmn.com/news/norwegian-study-reveals-krill-oil-protects-against-cognitive-deterioration) - Highlights Administering krill oil to PD worm model preserves neurons associated with cognition and reduces the accumulation of the deleterious ⍺-synuclein protein. Krill oil-treated PD worms display reprogrammed gene activity that attenuates hallmarks of aging like harmful, reactive oxygen-containing molecule buildup — oxidative stress. Krill oil-treated worms exhibit improved cognitive function and a diminished predicted
- [Study Shows Resveratrol Reverses Age-Related Infertility and Restores Mitochondrial Health](https://www.nmn.com/news/study-shows-resveratrol-reverses-age-related-infertility-by-restoring-mitochondrial-health) - Highlights: Resveratrol treatment restores the live offspring rate of middle-aged mice. Treatment with resveratrol restores the mitochondrial health of aged oocytes.Increased live offspring rate correlates with increased activation of sirtuins — longevity-associated enzymes that modulate cell survival processes. The female reproductive system ages faster than any other system in the body. Meanwhile, due to social, cultural,
- [Whey Protein Shown to Reduce Cardiac Scarring and Blood Vessel Thickness](https://www.nmn.com/news/whey-protein-shown-to-reduce-cardiac-scarring-and-blood-vessel-thickness) - Highlights: A whey protein found in milk, ɑ-lactalbumin, was shown to decrease age-related changes in heart cells after experimentally-induced senescence (a state of cellular stasis associated with aging).Lactalbumin decreased DNA damage, cellular stress, and inflammation in artificially-aged cardiovascular cells.Treatment with lactalbumin also reduced inflammation and cardiac scarring in the hearts of aged mice while reducing
- [Study Finds Poor Psychological States Accelerate Aging More than Smoking](https://www.nmn.com/news/study-finds-poor-psychological-states-accelerate-aging-more-than-smoking) - Highlights Adverse mindsets like feeling fearful, hopeless, or unhappy add an estimated 1.65 years to a person’s biological age. In comparison, smoking adds about 1.25 years to an individual’s age, while having liver disease or a stroke adds an extra 0.9 years and 1.5 years, respectively. Confronting psychological factors with online resources like futurself.ai may
- [Study Shows GDF-11 Protein from Young Marrow Alleviates Muscle Decline](https://www.nmn.com/news/study-shows-young-marrow-alleviates-muscle-decline) - Highlights: Bone marrow from young mice increases muscle size and enhances the strength and endurance of prematurely aged mice. Young bone marrow elevates muscle regeneration, reduces cell death, and repairs damaged mitochondria. A protein called GDF-11 essentially replicates the benefits of young bone marrow transplantation. Our muscles progressively deteriorate as we age, leading to sarcopenia, the age-related
- [Study Suggests Rapamycin Can Overcome Genetic Differences in Vascular Aging](https://www.nmn.com/news/study-suggests-genetic-differences-in-aging-can-be-rescued-by-rapamycin) - Highlights: Old rats with low running capacity have increased artery stiffness — the arterial hardening associated with heart disease and early death. The immunosuppresent drug rapamycin can rescue mitochondrial impairment in artery cells from old rats with low running capacity. Our capacity for endurance exercise depends largely on our cells’ ability to utilize oxygen. Older adults
- [Canadian Toxicity Study Shows Little to No Adverse Effects of NMN](https://www.nmn.com/news/safety-evaluation-of-nmn-shows-limited-to-no-adverse-effects) - Highlights: 1000 mg/kg of NMN (Restorin) for female rats and 500 mg/kg for male rats is well-tolerated over the course of ninety-one days. Major side effects include weight loss and decreased food consumption. Nicotinamide adenine dinucleotide (NAD+) is an essential molecule involved in a myriad of cellular processes that keep our cells functioning and alive.
- [Fasting, Not Simply Calorie Reduction, Stimulates Age-Defying Metabolic Benefits in Mice](https://www.nmn.com/news/fasting-not-simply-calorie-reduction-stimulates-age-defying-metabolic-benefits-in-mice) - Highlights · Reduced calorie intake boosts insulin sensitivity only when extended fasting periods are incorporated in mice. · Fasting also extends lifespan in mice, while reduced calorie intake on its own diminishes lifespan. · Extended periods without food confer metabolic and longevity-related benefits. When trying to lose weight, typically with goals of
- [Study Identifies Genes Linked to Mammalian Lifespan Extension](https://www.nmn.com/news/genes-linked-mammalian-lifespan-extension) - Highlights · DNA sequence analysis in longer-living mammals points to 2,004 longevity associated genes.· An additional analysis identified four genes whose rate of protein evolution correlated with longevity in mammals.· These genes encode proteins that show more stability in long-lived mammals like humans. Everything about our biology, from eye and hair color
- [Drugs Increasing Protein Synthesis Accuracy Makes, Yeast, Worms, and Flies Live Longer](https://www.nmn.com/news/with-less-protein-synthesis-errors-yeast-worms-flies-live-longer) - Highlights · A mutation that gives single-cell organisms called archaea improved accuracy of protein fabrication provides survival advantages.· Yeast, worms, and flies with this mutation are longer-lived, healthier, and heat resistant. · Certain anti-aging drugs, like rapamycin, increase protein production accuracy. For cells to make proteins,
- [Introducing Essential Developmental Protein Reverses Aging in Human Muscle Cells](https://www.nmn.com/news/essential-developmental-protein-reverses-aging-human-muscle-cells) - Highlights · Boosting NANOG protein levels reverses signs of aging like chromosomal instability and abnormal mitochondria by improving the DNA damage response in human muscle progenitor cells. · Restoring muscle progenitor cells to their youthful state may offer a way to drive muscle regeneration and combat age-related musculoskeletal problems.
- [Precision Nutrigeroscience: Using Individualized Dietary Treatments to Slow Aging](https://www.nmn.com/news/precision-nutrigeroscience-using-individualized-dietary-treatments-slow-aging) - Highlights · Nutrient restriction promotes health and counteracts age-related morbidities, but, given the difficulty to restrict nutrients in humans, efforts are needed to identify compounds or behavioral interventions that induce or mimic dietary restriction.· A viable and seemingly promising approach is to optimize strategies that combine moderate dietary restriction
- [Mayo Clinic Study Shows Spinal Cord Nerves Depend on NAD+](https://www.nmn.com/news/mayo-clinic-spinal-cord-nerve-projection-health-nad) - Highlights· Diets high in fat adversely impact the survival and function of myelin-producing cells called oligodendrocytes by reducing NAD+ levels in mice.· Inactivating CD38 — an NAD+ consuming enzyme — by genetic or drug-based manipulation enhances oligodendrocyte survival.· Restoring NAD+ levels with the NAD+ precursor NMN
- [Why NAD+ Declines With Age](https://www.nmn.com/news/why-nad-declines) - From the simplest single-celled organisms to humans, all of life cannot exist without a molecule called nicotinamide adenine dinucleotide (NAD+). This molecule has its hands in many processes necessary for humans — and many organisms examined like yeast, flies, worms, and mice — to live a long and healthy life, let alone just being alive.
- [Removing “Zombie” Cells With Senolytics Improves Bone Fracture Healing in Young Mice](https://www.nmn.com/news/removing-zombie-cells-improves-bone-fracture-healing-in-young-mice) - Highlights· Saul and colleagues find non-replicating (senescent) cells accumulated during bone healing in young adult mice.· Following a fracture, intermittent treatment with compounds that selectively eliminate senescent cells (senolytics) heals bones twice as fast.· The resulting bone had an increased volume and improved biomechanical properties, such as increased stability. Our bones become
- [New Treatment Selectively Destroys Aging-Linked Cells](https://www.nmn.com/news/new-treatment-recognizes-destroys-aging-linked-cells) - Highlights · Antibodies targeting the cell surface protein B2M, present only on senescent cells, were linked to a cell toxic compound to specifically destroy senescent cells.· The antibody-drug conjugate primarily eliminates cells that enter senescence from stress instead of excessive divisions (replicative senescence). · Joining antibodies specifically targeting senescent cells to toxic
- [Green Tea Compounds Enhance Fitness & Lifespan of Nematodes](https://www.nmn.com/news/green-tea-compounds-enhance-fitness-lifespan-nematodes) - Highlights· C. elegans treated with EGCG and ECG reached an average lifespan extension of 6.9% and 6.2%, respectively.· Life span extension by EGCG and ECG involves the activation of energy sensors, ultimately boosting oxidative stress resistance.· The long-term effects also included reduced fat content in C. elegans after five days of catechin
- [NIH Launches Program to Map  Cells Linked to Human Health, Aging, and Disease](https://www.nmn.com/news/nih-launches-program-map-cells-linked-human-health-aging-disease) - The NIH is out to get at the root of senescence — a phenomenon causally linked to aging and age-related diseases in which cells stop dividing. And to do so, the NIH Common Fund has established the Cellular Senescence Network (SenNet) Program to comprehensively identify and characterize the differences in senescent cells across the body,
- [Longevity-Linked Protein Protects Heart Muscle From Lost Blood Flow, Study Shows](https://www.nmn.com/news/longevity-linked-protein-protects-heart-muscle-study-shows) - Highlights · Boosting levels of the protein TERT, which is critical for telomere length maintenance, exclusively in mitochondria, protects heart muscle integrity after infarction.· Increasing TERT levels in mitochondria enhances their power-generating capabilities to reduce dead tissue buildup after ischemic injury. · When a procedure called
- [FDA-Approved Antibiotic Extends Lifespan In Both Young and Old Lab Worms](https://www.nmn.com/news/fda-approved-antibiotic-extends-lifespan-young-old-lab-worms) - Highlights· Out of 21 compounds that increase lifespan in young C. elegans, only minocycline extended lifespan in worms treated starting in adulthood.· Minocycline, which is already FDA-approved as an antibiotic for acne, reduces toxic protein aggregation even in old worms.· The neuroprotective and aggregation-preventing effects of
- [Several Anti-Aging Molecules Work in Animals, But Will They Work in Humans?](https://www.nmn.com/news/why-do-anti-aging-molecules-that-work-mice-fail-human-clinical-trials) - Imagine a world with a cure for all chronic conditions from Alzheimer’s, cancer, and diabetes to aging. Well, that world exists — if you’re a laboratory mouse. When partaking in longevity-promoting experimentation, even some worms have lived a lifetime and a half longer than their non-tampered counterparts. Unfortunately for humans, a good chunk of these
- [Berberine Improves Spatial Memory in a Mouse Model of Alzheimer’s](https://www.nmn.com/news/berberine-spatial-memory-mouse-model-alzheimers) - Highlights· Berberine acts as an effective agent in relieving cognitive impairment in mice modeling Alzheimer’s disease.· Levels of toxic proteins linked to Alzheimer’s disease called amyloid plaques and neurofibrillary tangles are improved with berberine treatment.· The stress of a cell compartment called the endoplasmic reticulum, which
- [Researchers Alleviate Diabetes By Deleting Senescent Fat Cells](https://www.nmn.com/news/researchers-alleviate-diabetes-deleting-dysfunctional-cells) - Highlights· Specific senescent cells accumulate in fat with obesity.· Intermittent clearance of these senescent cells both prevents and alleviates insulin resistance.· A drug combination of dasatinib and quercetin reduces these senescent cells in human fat and alleviates metabolic harm in rodents. More than 93 million US
- [Mayo Clinic Study Indicates Dasatinib Provides Antidiabetes Benefits in Humans](https://www.nmn.com/news/mayo-clinic-dasatinib-provides-antidiabetes-benefits-humans) - Highlights The study screened over 9 million patients with type II diabetes and an underlying predisposition to cancer.Dasatinib lowered measurements of type II diabetes severity, like sugars in the blood, in the research conducted over the course of 26 years.This study provides clues that, by targeting aged, non-proliferating cells (senescent cells), we may be closer
- [Long-term NMN Administration Has Anti-Aging Effects in Ovaries](https://www.nmn.com/news/long-term-nmn-administration-anti-aging-effects-ovaries) - Highlights Forty-week-old mice treated with NMN for 20 weeks exhibited improvements to their reproductive capacity.This NMN treatment regimen improved the number of ovarian follicles – structures that support egg (ovum) growth and maturation – at several critical stages.Additionally, markers for replicative cell arrest (senescence) in ovaries were significantly reduced in mid-aged mice receiving long-term treatment
- [Scientists' Find New Angle for Alzheimer’s Treatment](https://www.nmn.com/news/activation-genome-protecting-protein-preserves-neuron-survival-cognition-alzheimers-models) - Highlights An enzyme that helps protect chromosome ends called TERT is downregulated in Alzheimer’s disease.TERT activation alleviates toxicity and enhances brain connectivity in an Alzheimer’s disease mouse model. In human cells with Alzheimer's, TERT activation alleviates toxicity in neurons and increases gene activity related to learning and memory impairment. Alzheimer’s disease is the most common
- [MIT Researchers Show Key Brain Cells Age Prematurely in Down Syndrome](https://www.nmn.com/news/mit-researchers-brain-cells-age-prematurely-down-syndrome) - Highlights The third copy of chromosome 21 disrupts the nuclear architecture and genome organization in neural progenitors — a key cell type of the developing brain.Neural progenitor cells harboring three copies of chromosome 21 display signatures of an aging-associated state known as cellular senescence.Drugs targeting senescent cells (senolytics) ameliorate trisomy-21-associated dysfunctions in neural progenitor cell
- [Are All Senescent Cells Bad?](https://www.nmn.com/news/are-all-senescent-cells-bad) - Research on cell senescence has boomed in the last decade due to its pervasive implications. Senescent cells have gotten a pretty bad rap because these growth-arrested cells are known mostly for accumulating with age and causing various age-related diseases. And when certain populations of senescent cells get eliminated, researchers have been seen some remarkable changes,
- [Urolithin A Improves Muscle Health in Older Adults](https://www.nmn.com/news/urolithin-a-improves-muscle-health-in-older-adults) - Highlights A small cohort of older adults (65 to 90 years) received oral supplementation with 1000 mg of urolithin A daily.Supplemented participants significantly improved muscle endurance for leg and hand skeletal muscles.Urolithin A improved mitochondrial health biomarkers in participants’ blood. To move, breathe, and have our hearts beat, we need healthy muscles supplied with plenty
- [Centenarian-Sourced Probiotic Mixed With Dietary Fiber Has Anti-Aging Effects](https://www.nmn.com/news/centenarian-sourced-probiotic-dietary-fiber-mixture-shows-anti-aging-effects) - Highlights A probiotic isolated from centenarians called LTL1361 mixed with dietary fiber alleviates age-related cognitive impairment and protects the brain of healthy aging mice.This probiotic and dietary fiber combination also improves gut function and reduces inflammation in the blood and colon.These findings suggest the LTL1361 and dietary fiber mixture as a novel and promising anti-aging
- [Selenium Mimics Exercise, Doubles New Neurons, and Reverses Memory Loss](https://www.nmn.com/news/selenium-mimics-exercise-doubles-new-neurons-and-reverses-memory-loss) - Highlights By mimicking the effect of exercise, selenium increases new neurons (neurogenesis) two-fold in the aging brain of mice.In mice, selenium reverses the cognitive decline associated with aging and brain injury.Selenium may boost cognition in individuals who cannot exercise due to advanced age, frailty, or disability. Exercise has often been touted as the best medication
- [Uridine Treatment Enhances Aged Tissue Regeneration](https://www.nmn.com/news/uridine-treatment-tissue-regeneration) - Highlights A set of regeneration-related metabolite modulators is conserved across species, including the metabolite uridine.Uridine can rejuvenate aged human stem cells and promote regeneration of various tissues in mice. These observations will open new avenues for metabolic intervention in tissue repair and regeneration. Many of our body parts are capable of regeneration — a rejuvenating process
- [UK Study Shows Older Workers' Health Can’t Catch Rising Retirement Ages](https://www.nmn.com/news/health-older-workers-increasing-retirement-ages) - Highlights Life expectancy projections from age 50 show a 4.10-year and 2.46-year increase in life expectancy for men and women, respectively.Healthy working life expectancy is projected to be 0.38 years and 1.08 years longer for men and women, respectively, in 2035 compared to 2015.The widening gap between healthy working life expectancy and life expectancy from
- [Experimental Cancer Drug Mimics Beneficial  Fasting Effects](https://www.nmn.com/news/cancer-drug-beneficial-effects-fasting) - Highlights A drug used to treat liver tumors, ADI-PEG 20, improves whole-body metabolism, insulin sensitivity, and fat imbalance in obese mice.ADI-PEG 20 mimics these fasting benefits in obese mice by driving arginine turnover and improving liver function.The arginine pathway can be manipulated by ADI-PEG 20, which may help treat obesity and related disorders. Obesity is
- [Study Shows NMN May Treat Rare Transmissible Neurodegenerative Disorder](https://www.nmn.com/news/nmn-neurodegenerative-disorder) - Highlights Mitophagy – the clearance of damaged mitochondria – is impaired in a mouse cell model of a rare neurodegenerative condition known as a prion disease.Supplementation with NMN or urolithin A (UA) in neuronal cells with prion disease significantly revives mitophagy.However, only NMN and not UA could alleviate prion-induced mitochondrial damage and dysfunction as well
- [Lithium Reduces Senescence and Preserves Kidney Function in Aging Patients](https://www.nmn.com/news/lithium-senescence-kidney-function) - Highlights Levels of an enzyme called GSK3β increases with age in the kidneys of humans and mice, mainly localizing to kidney cells critical for blood-filtering called podocytes.Blocking GSK3β in mice mitigates podocyte senescence – an aging-related phenomenon of cellular arrest in growth and replication – and improves kidney aging.Long-term lithium carbonate therapy in patients inhibits
- [Swiss Researchers Show NMN Could Help Teenagers Cope with Stress](https://www.nmn.com/news/nmn-may-help-kids-cope-with-stress) - Highlights Adult mice stressed during puberty exhibit increased fat deposition and sociability deficits.Reduced levels of the NAD+ generating enzyme NAMPT in fat and blood link lifelong reductions in sociability to stress during puberty.Impairments in sociability and brain function are prevented by treatment with nicotinamide mononucleotide (NMN), an NAD+-boosting compound. Being overweight as a child can
- [Chinese Researchers Show NMN Rejuvenates Brain Cells In Aged Mice](https://www.nmn.com/news/nmn-rejuvenates-brain-cells-in-aged-mice) - Highlights Levels of an enzyme called SIRT2 and NAD+ are substantially reduced in aged oligodendrocyte precursor cells (OPCs) — myelin generating cells, preventing neurons from being myelinated efficiently.Supplementing with NMN restores SIRT2 and rejuvenates aged OPCs, promotes their maturation, and enhances myelination in the aged central nervous system.The elevation of NAD+ levels via NMN injection
- [Northwestern University Study Shows NMN Improves Motor Neurons in ALS Mice](https://www.nmn.com/news/northwestern-university-researchers-show-nmn-improves-motor-neurons-in-als-mouse-model) - Highlights In a mouse model of amyotrophic lateral sclerosis (ALS), defects begin to occur early in the movement controlling centers of the brain, including reduced levels of NAD+.Treatment with the NAD+ precursor NMN improves the health of motor neurons from the ALS mouse model.Proper modulation of metabolomic imbalance via NAD+ precursors could offer therapeutic strategies
- [Metformin Ups NMN Production to Elicit Anti-Aging Effects](https://www.nmn.com/news/metformin-anti-aging-effects-nmn) - Highlights A micro RNA – a tiny molecule that can bind RNAs to modulate protein synthesis – called​​ miR-146a impedes the anti-aging effect of a cell survival pathway related to metformin, NAD+, and sirtuins.Metformin stops miR-146a from repressing NAMPT, the enzyme that leads to the production of NAD+.These findings suggest that inhibiting miR-146a could help
- [NMN Reels Back Metabolic Problems in Obese Mice](https://www.nmn.com/news/nmn-reverses-metabolic-dysfunction-obese-mice) - Highlights: Deleting NAMPT – the enzyme that synthesizes NMN – from mouse intestinal cells leads to a muted insulin response and high blood sugar levels.Obese mice also exhibit this phenomenon, with stunted NAD+ levels leading to dysfunctional insulin secretion and glucose regulation.Adding NMN to the water of these mice reverses the metabolic derangements caused by
- [Niacin Limits Alzheimer’s in Mice](https://www.nmn.com/news/niacin-limits-alzheimers-progression-animal-model) - Highlights HCAR2 gene inactivation in Alzheimer’s mice exacerbates cognitive impairments and amyloid-β burden.HCAR2 activation using the FDA-approved drug NIASPAN® (niacin extended-release tablets) has protective and therapeutic effects in mice, modulating the microglial response to amyloid pathology.The results suggest that modulating microglia activity through HCAR2 might effectively prevent or treat Alzheimer’s. If you open the cooler
- [NMN Generating Enzyme Drives Fasting-Related Fat Burning](https://www.nmn.com/news/nmn-generating-enzyme-drives-fasting-benefits) - Highlights NAMPT, the enzyme that generates NMN, is needed to enhance the balance of fat (lipid) and sugar (glucose) in metabolically stressed mice.In diabetic mice, NAMPT increases thermogenesis – the metabolic process by which organisms burn calories to generate heat.These data highlight a direct therapeutic role for NAMPT activation and NMN administration in liver cells
- [Young Adults With High Blood Sugar and Low HDL Have Increased Alzheimer's Risk](https://www.nmn.com/news/fat-sugar-levels-age-35-linked-alzheimers) - Highlights This report demonstrates for the first time that low high-density lipoprotein (HDL) and elevated glucose levels measured as early as age 35 are associated with Alzheimer’s later in life.These findings suggest that careful management of cholesterol and glucose levels beginning in early adulthood can lower Alzheimer’s disease risk. There’s a saying that there’s no
- ["Fat Burning" Molecule Treats Age-Related Muscle Loss](https://www.nmn.com/news/mitochondrial-modulator-treats-age-related-muscle-loss) - Highlights Elderly, overweight mice treated with BAM15 — a compound called a mitochondrial uncoupler — have increased muscle mass and improved muscle function.BAM15 treatment leads to the removal of damaged mitochondria and the generation of healthy mitochondria.This improvement is tied to the reduced “inflammaging,” or age-related inflammation, linked to muscle loss. In the United States,
- [NIA Study Shows Ginger Extract Selectively Kills Aging-Related "Zombie" Cells](https://www.nmn.com/news/ginger-extract-senescent-cells) - Highlights Ginger extract selectively caused the death of senescent cells without affecting proliferating cells.Among the ginger extract components, gingerenone A showed promising senolytic properties and selectively eliminated cultured human senescent cells.Gingerenone A was more selective at eliminating senescent cells than a known and popular senolytic cocktail, dasatinib and quercetin. In animals, eliminating senescent cells –
- [Tocotrienols Have Anti-Obesity Effects](https://www.nmn.com/news/tocotrienols-have-anti-obesity-effects) - Highlights Treatment with vitamin E homologs called tocotrienols (T3s) attenuated body weight gain in mice fed high-fat diets.T3s also blocked blood cholesterol elevation and white adipose tissue accumulation in high-fat diet-treated mice.Additionally, T3s also inhibited liver damage from obesity. Obesity kills, as over four million people die each year due to obesity-related disorders. This condition
- [Clinical Study Indicates that NMN Efficaciously Increases Blood NAD+ in Humans](https://www.nmn.com/news/nmn-increases-blood-nad-humans) - Highlights Healthy human subjects who took two 125 mg doses of NMN per day for 12 weeks nearly doubled their whole blood nicotinamide adenine dinucleotide (NAD) levels. No adverse physiological side effects, such as altered body weight or elevated blood pressure, were observed following NMN supplementation. Whole blood NAD+ levels plateaued after four weeks of
- [The Senolytic Navitoclax Improves New Neuron Production and Memory](https://www.nmn.com/news/senolytic-navitoclax-improves-neuron-production-spatial-learning) - Highlights Senescent neurons build up in the brain structure associated with learning and memory – the hippocampus. Senescent neuron accumulation in the hippocampus correlates with declining production of new brain cells (neurogenesis). Injecting the senolytic agent navitoclax into aged mouse brains eliminates senescent neurons, improves neurogenesis, and revamps memory performance. As we grow older, we
- [Uthever NMN Does Not Boost NAD+ or Improve Physical Endurance in Middle-Aged and Elderly Adults](https://www.nmn.com/news/uthever-nmn-nad-endurance) - Highlights Middle-aged and older adults treated with NMN did not show an increase in blood NAD+ levels.Participants included in the study exhibited no significant improvements in physical performance.No significant differences in blood pressure were found after taking NMN. Recent clinical trials suggest that taking nicotinamide mononucleotide (NMN) can improve health parameters like insulin sensitivity, at
- [The Naturally Occurring Senolytic 25HC Restores Age-Related Muscle Loss](https://www.nmn.com/news/the-naturally-occurring-senolytic-25hc-restores-age-related-muscle-loss) - Highlights Injecting aged mice with 25HC eliminates senescent cells and restores their muscle mass by a dramatic 23%. As cells enter an aged, non-proliferating (senescent) state, the gene CRYAB exhibits increased activation and prevents cell death. Senescent cells with high CRYAB activity are eliminated by the naturally-occurring metabolite 25HC in mouse and human cell lineages.
- [Study Shows the Combination of Nicotinamide and D-Ribose Improves Insulin Sensitivity](https://www.nmn.com/news/nad-booster-riagev-improves-insulin-sensitivity-and-stress-hormone-levels) - Highlights Nicotinamide and D-ribose supplementation significantly increases blood NAD+ and NADP levels, along with energy molecules ATP and ADP. The nicotinamide and D-ribose combination substantially diminishes blood glucose while preserving insulin levels, indicating an increased insulin sensitivity.Taking NAD+-boosting combination diminishes the stress hormone cortisol and increases the abundance of the antioxidant glutathione. Molecules associated with nicotinamide
- [Urolithin A Enhances Physical Performance in Overweight Adults](https://www.nmn.com/news/urolithin-a-obesity) - Highlights Four months of urolithin A supplementation increases muscle strength by 12% in overweight adults. Overweight adults treated with urolithin A exhibit a gain in walking capabilities following supplementation. Molecular markers of mitochondrial health linked to aging improve after urolithin A supplementation. Dietary supplements to improve cardiovascular, neurological, and muscle function have become a hot
- [Scientists Reverse Age-Related Infertility by Boosting Mitochondrial Function](https://www.nmn.com/news/removal-of-ovarian-scar-tissue-restores-age-related-infertility) - Highlights Fibrotic tissue builds up in the ovaries of aged and obese female mice long before menopause, which correlates with declining fertility. In obese mice, treatment with pharmaceuticals that improve mitochondrial function and reduce fibrosis restores ovulation and fertility. Reducing fibrosis with pharmaceuticals also restores ovulation in aged mice. With age comes declining fertility for
- [NMN, Metformin, and Rapamycin Mitigate Age-Related Cognitive Impairment](https://www.nmn.com/news/nmn-metformin-and-rapamycin-mitigate-age-related-cognitive-impairment) - Highlights Treatment with NMN, metformin, or rapamycin improves learning and memory in rats modeling vascular cognitive impairment (VCI), the second leading cause of dementia after Alzheimer's disease. The compounds reduce brain lesions caused by the lack of blood flow that characterize VCI. The degradation of the fatty tissue that makes our neurons fire faster called
- [Type 2 Diabetes Drug Revitalizes Aged Arteries](https://www.nmn.com/news/type-2-diabetes-drug-revitalizes-aged-arteries) - Highlights Aged humans and mice both display vascular dysfunction, stiffened arteries that are unable to dilate. Treating aged mice with the type 2 diabetes drug empagliflozin (Empa) improves their vascular dysfunction. Empa treatment also decreases the abundance of a protein called F-actin, which appears to contribute to age-related vascular dysfunction. Our blood vessels have the
- [Harvard Scientists Propose Using Fecal Transplants from Our Younger Selves to Reverse Aging](https://www.nmn.com/news/harvard-age-related-disease-fecal-transplants) - Highlights Changes in the way we live and eat over the last few decades have changed the composition of our gut microbes – the microbiome. Microbiome changes have been associated with a higher incidence of conditions like digestive ailments, type 2 diabetes, and cardiovascular disease. To restore a healthier microbiome and mitigate diseases, researchers propose
- [European Study Confirms NMN Safety and Highest Recommended Dose](https://www.nmn.com/news/study-reveals-nmn-safety-and-its-highest-recommended-dose) - Highlights Rats display no physical abnormalities from consuming 1500 mg/kg/day – the equivalent of 900 mg per day for an average human – for a 90-day period. Rats that consume 1500 mg/kg/day of NMN exhibit increased levels of liver enzymes that may indicate liver damage, an effect not associated with lower NMN doses. Male rats
- [How Do NAD+ Precursors Get Incorporated Into Cells?](https://www.nmn.com/news/how-do-nad-precursors-get-incorporated-into-cells) - Various molecules, all differing by a few atoms, get passed along and transformed by different receptors and enzymes inside and outside cells to create the vital molecule nicotinamide adenine dinucleotide (NAD+). But these distinct NAD+ precursors, whose differences in atomic structures can be distinguished by just a letter in their formula or a word in
- [NMN Alleviates Kidney Tissue Scarring in Rodents](https://www.nmn.com/news/nmn-alleviates-kidney-tissue-scarring) - Highlights · Rodents lacking SIRT1 have an aggravated kidney scarring response.· Stimulating SIRT1 in rodent kidney cells with NMN reduces the activation of the pro-scarring markers. When our kidneys become diseased, they undergo irreversible changes in function and overall structure that progress over months and years. Tissue scarring, or what’s called fibrosis in
- [NMN Makes Ears Resistant to Chemotherapy Poisoning in Mice](https://www.nmn.com/news/nmn-ears-resistant-chemotherapy-poisoning-mice) - Highlights · Cisplatin causes ototoxicity — ear poisoning — and reductions in the cell essential molecule nicotinamide adenine dinucleotide (NAD+). · The NAD+ precursor nicotinamide mononucleotide (NMN) protects cochlear cells from cisplatin-induced ototoxicity in mice, preserving hearing. There are few, if any, silver bullet clinical treatments for cancer, as
- [How Much and for How Long Can I Take an NAD+ Precursor?](https://www.nmn.com/news/how-much-and-for-how-long-can-i-take-an-nad-precursor) - NAD+, a compound essential for enzymes to participate in a great deal of biochemical reactions, has been found to be the key that activates enzymes that drive hundreds of diverse biological processes. In mammalian cells, NAD+ is one of the most abundant molecules, second only to water. Given the vitality of NAD+, there has been
- [Study Shows  Resveratrol Slows Cardiac Aging via Senolytic Function ](https://www.nmn.com/news/resveratrol-cardiac-aging-zombie-cell-elimination) - Highlights: Treatment with resveratrol restores the abnormal heart rhythms produced by aged cardiac cells. Resveratrol also diminishes senescent cells, acting as a senolytic — drug that eliminates senescent cells. Partakers of wine have postulated that their drinking habits could benefit their health, as wine contains resveratrol, a powerful antioxidant associated with cardiovascular protection and slowing aging.
- [Astellas' New NAD+ Boosting Drug  Reduces Damage Caused by Heart Attacks](https://www.nmn.com/news/astella-drug-may-reduce-damage-caused-by-stroke) - Highlights: A new drug called MK-0159 was designed to block an enzyme (CD38) that degrades NAD+ — an essential molecule that declines with age. Boosting NAD+ with MK-0159 and/or the NAD+ precursor NR (nicotinamide riboside) reduces heart tissue death in mice modeling heart disease. MK-0159 also raises NAD+ levels in human blood vessel cells. When our coronary
- [Study Suggests Withdrawing Blood Reverses Skin Aging](https://www.nmn.com/news/donating-blood-reverses-skin-aging) - Highlights Draining blood from mice at regular two-week intervals improves their skin and reduces the prevalence of senescent cells, which underlie many age-related diseases. Regular blood donations also lead to reduced skin iron content, which can drive a higher abundance of damaging, oxygen-containing molecules (reactive oxygen species). Higher skin content of the anti-inflammatory protein, TGF-ß1,
- [Regular Sleep-Wake Cycle Essential for  Prolonged Lifespan via Dietary Restriction](https://www.nmn.com/news/sleep-wake-cycle-life-extension-dietary-restriction) - Highlights Dietary restriction (DR) — reducing calorie intake — doubles the lifespan of flies, but with disrupted circadian rhythms, DR increases lifespan by only 25%. Doubling lifespan through DR and circadian rhythms is mediated by reduced inflammation. Circadian rhythms (the body’s 24-hour timed routine) modulate our behavior by anticipating changes in our environment, including light exposure,
- [NMN Dramatically Increases Cellular Energy Metabolism Through AMPK Activation](https://www.nmn.com/news/nmn-dramatically-increases-activation-of-metabolic-regulator-ampk-in-human-cells) - Highlights Treating human breast cancer cells with NMN increases the activity of AMPK, a metabolic master switch that enhances cell energy production, by 1,200%. NMN triples the concentration of intracellular NAD+, an essential molecule for cell energy synthesis known to decrease in abundance as people age. These results support that NMN confers anti-aging benefits by
- [FDA Considers Historic Nixing Common Antioxidant As Dietary Ingredient](https://www.nmn.com/news/fda-considers-historic-disqualification-common-antioxidant-dietary-ingredient) - Highlights In 2020, the FDA issued a series of warning letters to marketers of hangover cures for use of N-acetyl-L-cysteine (NAC). The Council for Responsible Nutrition (CRN) says that the US Food and Drug Administration (FDA) is dodging a central legal issue in its stance on NAC.The CRN requests that the FDA commit to substantively
- [New Intranasal and Injectable Gene Therapy Extends Lifespan in Mice](https://www.nmn.com/news/intranasal-injectable-gene-therapy-extends-lifespan-mice) - Highlights · This is the first report of researchers using cytomegalovirus successfully as both an intranasal and injectable gene therapy system to extend longevity.· The treatment significantly improved glucose tolerance, physical performance, and prevented loss of body mass and alopecia. · Intranasal and injectable preparations performed
- [Blood Plasma Exchange Slows Alzheimer's in Landmark Clinical Study](https://www.nmn.com/news/blood-plasma-exchange-slows-alzheimers) - Highlights Plasma exchange improved language fluency and processing speed in patients with mild Alzheimer’s disease.This treatment improved short-term verbal memory in patients with moderate Alzheimer’s disease.The quality of life improved, and the neurological status was stable in these Alzheimer’s patients. One powerful anti-aging technique used on rodents in labs is the transplantation of blood from
- [Rejuvenation: The Science of Reversing Biological Age](https://www.nmn.com/news/reversing-biological-age-rejuvenation-science) - There’s a lot of talk these days about stopping or slowing down aging. But what about rejuvenation — the reversal of aging? Can we actually turn back the clock to become biologically younger? Anti-aging vs. Rejuvenation First things first: what constitutes rejuvenation, and how does it differ from anti-aging? The line between rejuvenation therapies and
- [Pro-Longevity Molecules in ‘Young Blood’ Rejuvenate Aged Mouse Muscle](https://www.nmn.com/news/pro-longevity-protein-young-blood-nanoparticles-rejuvenate-aged-mouse-muscle) - Highlights Blood from young mice rejuvenates aged muscle through membrane-bound packages in the blood called extracellular vesicles (EVs). Aging affects the cargo carried by EVs, reducing mRNA levels that encode a pro-longevity protein called Klotho.Injection of EVs containing Klotho mRNA improved muscle regeneration, copying the effects of blood from young mice on aged muscle. From
- [Rockfish DNA Reveals Genetic Clues For Longevity](https://www.nmn.com/news/rockfish-dna-reveals-genetic-clues-for-longevity) - Highlights · Kolora and colleagues sequenced over 100 fish from 88 rockfish species to identify genes that evolved and drive lifespan.· Genes linked to a longer lifespan were related to immunity and inflammation, size and environmental adaptations, and DNA repair pathways. · Duplications in the immune
- [Bezos Backed Silicon Valley Biotech Startup Aims to Make People Younger](https://www.nmn.com/news/billionaire-backed-silicon-valley-biotech-startup-aims-to-make-people-younger) - In the Los Altos Hills above the city of Palo Alto, California, a large gathering of scientists met last October to discuss how to use biotechnology research to make people younger. They met at Russian-born billionaire Yuri Milner’s super mansion. Milner’s enthusiasm for scientific philanthropy has recently taken a specific direction, focusing on anti-aging research,
- [How Does Space Travel Affect Natural Aging?](https://www.nmn.com/news/how-does-space-travel-affect-natural-aging) - Growing older can take a serious toll on the body. Bones become brittle, muscle shrinks, the immune system loses strength, and age-related ailments like arthritis can set in. More serious complications like declining cognitive function and heart disease can also take hold as the later years of life progress. These symptoms can also come from
- [How Do I Find Out My Biological Age?](https://www.nmn.com/news/how-do-i-find-out-my-biological-age) - Life is finite, and we literally or figuratively blow out some candles demarcating our chronological age every living year. But as we get older, some become frail and require assistance in daily routines, and others remain independent and seem to escape significant physiological deterioration until very extreme ages. This varying limit to our existence has
- [The Role of NAD+ Consuming Enzymes in Aging and Disease](https://www.nmn.com/news/the-role-of-nad-consuming-enzymes-in-aging-and-disease) - With age, the levels of nicotinamide adenine dinucleotide (NAD+) — the essential molecule with key roles in generating cell energy and maintaining DNA integrity — fall. This reduction in cell NAD+ levels is linked to many age-related diseases like cardiovascular impairments, metabolic disorders like obesity, and neurodegenerative diseases such as Alzheimer’s disease. But how falling
- [A Small Molecule That Activates NAMPT Boosts NAD+ Levels](https://www.nmn.com/news/small-molecule-activates-nampt-boosts-nad-levels) - Pharmacological strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is the activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase the production of nicotinamide mononucleotide (NMN), a predominant NAD+ precursor in mammalian cells. Using tiny, synthetic pharmaceuticals called small molecules that can activate NAMPT is a pioneering approach to raise intracellular
- [Supplementing NAD+ Preserves Neurons and Memory Formation in Rats with Hypoglycemia](https://www.nmn.com/news/nad-neurons-memory-formation-hypoglycemia) - Hypoglycemia, where blood glucose drops below normal, often comes from insulin treatment for diabetes. It can also cause brain injury and in severe cases drives neuronal death and cognitive impairment. Trying to control blood glucose with insulin reduces the risk of diabetes complications but that of severe hypoglycemia increases. Currently, there is no known therapeutic
- [GNC NMN Anti-Aging Products Make Global Debut at the China International Import Expo](https://www.nmn.com/news/gnc-nmn-anti-aging-products-make-global-debut-at-the-china-international-import-expo) - Nicotinamide mononucleotide (NMN) is a trending new ingredient in the field of dietary supplements. If you do a web search for NMN, you’ll find a seemingly endless list of products from a host of different companies that range in quantity, price, and, probably, quality. NMN supplements are making their way to the global stage and
- [Hydrogel Laced With Immune Cell Secretion Enhances Muscle Regeneration](https://www.nmn.com/news/nampt-supplementation-after-muscle-injury-enhances-muscle-regeneration) - Highlights Immune cells called macrophages are required for muscle repair.These macrophages stimulate muscle stem cell proliferation by secreting an NMN generating protein called NAMPT.Injured muscles in fish and mice can be repaired and regenerated with NAMPT treatment. No matter our age, our muscles are always undergoing wear and tear. To keep our muscles fresh and
- [Study Shows NAD+ Supplementation Protects Eye Cells Following Retinal Detachment](https://www.nmn.com/news/study-shows-nad-supplementation-protects-eye-cells-following-retinal-detachment) - Age-related eye disorders, such as age-related macular degeneration, diabetic retinopathy, and retinal detachment, often lead to severe visual impairment and irreversible vision loss. These disorders all feature degraded photoreceptors, the light-responsive cells in the eye, which separate from a cell layer that nourishes visual cells called the retinal pigment epithelium. This separation induces cell death,
- [Dr. Stephen Gardell on NMN Boosting Drugs](https://www.nmn.com/news/dr-stephen-gardell) - In today’s episode, our conversation is with Dr. Stephen Gardell and his research on an enzyme called NAMPT. This enzyme is important to us because it generates NMN, which is a precursor to the essential and aging-related molecule NAD+. He and his colleagues discovered small molecule activators of NAMPT that raise intracellular NAD+ levels, an
- [Unlocking the Fixed Aging Rate is Key to Lifespan Extension, Analysis Shows](https://www.nmn.com/news/unlocking-fixed-aging-rate-key-lifespan-extension-analysis) - Highlights · Historically, longer life expectancies arise from lower infant and juvenile death rates. · But the rate of aging has remained mostly constant even though life expectancies have improved. · To substantially increase future human life expectancy, we need to reduce the aging rate with
- [What’s the Difference Between Aging and Longevity?](https://www.nmn.com/news/difference-between-aging-longevity) - Living longer and living more years looking and feeling youthful and disease-free are not one and the same. Although our life expectancies are getting longer, people are also spending more years with age-related chronic diseases. That is to say, we are not necessarily getting more years of vitality and good health but instead are getting
- [Viome's At-Home Microbiome Testing Kit Hits Nordstrom’s Digital Shelves](https://www.nmn.com/news/viome-health-intelligence-test-nordstrom-2022) - They say that the way to a man’s heart is through his stomach. As it turns out, there’s some real truth to this expression as our gut health is intimately tied to our overall health and aging process. Personalized wellness regimes, such as customized diets, can significantly impact an individual's digestion, mood, energy, sleep, hormones,
- [Supplementing NAD+ Curtails Zika-Related Birth Defects, Promoting Newborn Mice Survival](https://www.nmn.com/news/supplementing-nad-zika-related-birth-defects-newborn-mice-survival) - Highlights · To restore NAD+ levels altered by the Zika virus, Hu and colleagues injected NAD+ or NR to preserve neurons, maintain brain weight, and improve survival. · The study suggests that boosting NAD+ levels in newborns infected with the Zika virus can slow or even prevent the virus’s damaging effects. Not only
- [How Anti-Aging Pioneer Aubrey de Grey Faces the Quandary of Growing Old](https://www.nmn.com/news/aubrey-de-grey-anti-aging-pioneer) - Highlights · Dr. Aubrey de Grey describes seven cell-level sources of aging that include mutations and cell waste accumulation. · Developing ways to treat these origins of aging are spawning anti-aging breakthroughs. · Quantum leaps of anti-aging technology will potentially provide capabilities to choose your body’s
- [NAD+ Boosters and their Potential as Longevity and Health-Promoting Compounds](https://www.nmn.com/news/nad-boosters-and-their-potential-as-longevity-and-health-promoting-compounds) - Researchers have demonstrated the crucial roles of the molecule nicotinamide adenine dinucleotide (NAD+) in health and longevity with laboratory animals like rodents, flies, and roundworms. Examples related to its benefits abound where boosting NAD+ levels improves cognition, metabolic health, and cardiovascular wellbeing in these animals during aging. This doesn’t seem surprising given that animal and
- [Fido Forever: Figuring Out How to Treat Aging in Dogs Can Help People Live Longer and Healthier](https://www.nmn.com/news/figuring-out-how-to-treat-aging-in-dogs-can-help-people-live-longer-healthier) - The fountain of youth for man’s best friend may be within hand's (or paw's) reach. With the collective effort from research projects and biotech startups, we’re making such significant strides towards prolonging the longevity of dogs that we may soon see the approval of lifespan-extending drugs in canines. But the quest doesn’t stop with dogs;
- [Research Reveals Excessive NR Can Disrupt Mouse Heart Mitochondria](https://www.nmn.com/news/research-reveals-too-much-nr-bad-mouse-hearts) - Highlights · High levels of mitochondrial damage can cause a drop in NAD+ levels, which ultimately drives a breakdown of function and communication in cardiac mitochondria. · Treatment with the NAD+ precursor NR does not get the desired effect of re-establishing protein activity dependent on NAD+. · These data
- [Gene Therapy Preserves Brain Matrix, Preventing Memory Loss in Aged Mice](https://www.nmn.com/news/preserving-brain-matrix-prevents-memory-loss-aged-mice) - Highlights · Reducing levels of a molecule in perineural nets — cartilage-like brain structures that encase neurons — simulated brain aging in young mice.· Restoring levels of this molecule, chondroitin 6-sulphates (C6S), with gene therapy and a drug candidate in aged animals rescued the memory deficits. The brain is
- [US Olympians Live About Five Years Longer](https://www.nmn.com/news/us-olympians-live-about-five-years-longer) - Highlights· An analysis of lifespan durations and causes of death for US Olympic athletes shows they live about five years longer than the rest of the population.· Elite competitors gain about two years of life from reduced cardiovascular disease risk and one and a half from diminished cancer risk.
- [Mutations Cause NAD+ Deficiency Linked Organ Malformation](https://www.nmn.com/news/mutations-nad-deficiency-organ-malfunction) - Highlights · Mutations that induce impaired NAD+ synthesis facilitate heart, kidney, vertebral, and limb malformations in a condition called Congenital NAD Deficiency Disorder.· This study expands the list of known disorder-associated mutations in enzymes participating in NAD+ synthesis.· The researchers suggest that certain mutations can cause organ
- [Scientists Find Exercise Protects Against Age-Related Attrition of Chromosome Ends](https://www.nmn.com/news/exercise-protects-against-age-related-attrition-chromosome-ends) - Highlights · Exercising induces enzyme (telomerase) activity that protects against age-associated chromosome end (telomere) deterioration. · Short-term and chronic exercising regimens have similar immediate telomerase activation effectiveness. · In endurance athletes, strenuous training invigorates telomerase activity, possibly accounting for their longer telomeres. The erosion of repetitive
- [Study Suggests Space Travel Provides Anti-Aging Benefits and  Improves Sleep Quality](https://www.nmn.com/news/space-travel-sleep-quality-anti-aging-benefits) - Highlights · When astronauts orbit the Earth, it strengthens their bodies’ daily rhythms (circadian clock). · During space flight, sleep quality improves along with electrical heart rhythms indicating cardiovascular health, overall well-being, and anti-aging benefits. · Higher intensity fluctuations in Earth’s magnetism in outer space correlate
- [A Difference of $139,000 in Net Worth was Linked to a 13% Relative Decrease in Death Probability, Study Shows](https://www.nmn.com/news/higher-midlife-net-worth-linked-longer-lives) - Highlights· In 5414 American participants, those who had accumulated a higher net worth by midlife had significantly lower mortality risk over the subsequent 24 years.· Findings from analyses of siblings and twins suggested that wealth accumulation at midlife may be associated with longevity among adults in the United States.
- [Vitamin B Alters the Risk and Severity of Alzheimer’s Disease](https://www.nmn.com/news/vitamin-b-alters-risk-severity-alzheimers-disease) - Highlights · Diet interventions to improve nicotinamide adenine dinucleotide levels (NAD+) reduce neurodegeneration in flies modeling Alzheimer’s disease. · Alzheimer’s flies with mutations suppressing an enzyme that consumes NAD+ also reduces neurodegeneration. · Vitamin B, which contains the NAD+ precursor nicotinamide, is associated with a lower
- [In the Mediterranean, Optimism and Social Support Are Ingredients For Longer Life](https://www.nmn.com/news/mediterranean-optimism-social-support-ingredients-longer-life) - Highlights · In Sardinia and Ikaria, Longevity Blue Zones (LBZs) in Italy and Greece, people over 90 report high optimism and self-rated health. · The social support of aged adults in these regions may spur their optimism and drive longevity. · Some of the factors found
- [Eliminating Senescent Cells Repairs Spinal Cord After Injury](https://www.nmn.com/news/eliminating-senescent-cells-repairs-spinal-cord-injury) - Highlights · Upon injury, senescent cells accumulate next to the lesion in the spinal cord. · Targeting senescent cells favors a pro-repair microenvironment in the spinal cord after injury. · Administration of senolytic drugs promotes recovery of spinal cord mediated functions, such as locomotion and sensation.
- [Inflammation-Based Aging Clock Predicts Chronic Diseases in Healthy Adults](https://www.nmn.com/news/aging-clock-predicts-age-related-diseases-healthy-young-adults) - Highlights · Researchers developed an aging clock based on inflammation patterns from the blood of 1,001 individuals aged 8 to 96 years. · The resulting inflammatory clock of aging (iAge) tracks for multiple diseases and frailty. · iAge also predicts cardiovascular disease and exceptional longevity in
- [Improving Healthspan Boosts Economy by Trillions of USD, Says Harvard Scientist](https://www.nmn.com/news/aging-therapeutics-benefit-future-economics) - Highlights · Treating anti-aging directly, instead of targeting specific individual diseases, puts more money in people's pockets, improving the economy.· Expanding the number of healthy years we live (healthspan) while compressing years in poor health dealing with disease can inject trillions of dollars into the US economy. As our
- [Former NFL Quarterback Jay Cutler Taps into NAD+ Therapy](https://www.nmn.com/news/nfl-jay-cutler-nad-therapy) - In the past few years, the American football leagues, from pee-wee to the highest professional level National Football League (NFL), have made rule changes to reduce significant injuries. Still, the elephant in the room remains a long-term impact on the body and brain. Wear-and-tear, hits, and injuries accumulated during athletes’ playing years can affect their
- [Age-Related Cognitive Decline Ameliorated with Testosterone in Male Rats](https://www.nmn.com/news/testosterone-age-related-cognitive-decline-rats) - Highlights· Testosterone supplementation improves the performance of aged male rats in behavioral tests measuring their exploratory capacity in a novel environment.· The sex hormone improves cognitive performance by preserving neurons and improving the function of their mitochondria. · These findings could aid the design of testosterone-based
- [Dasatinib and Quercetin Improve Aged Mouse Stem Cells that Regenerate Bone](https://www.nmn.com/news/dasatinib-quercetin-improve-bone-regenerating-stem-cells) - Highlights · Treating aged mouse bone marrow stem cells with Dasatinib and Quercetin substantially enhances their bone regeneration capacity. · These findings provide hope for using the two therapeutic agents to rejuvenate aged tissue in humans. Stem cells that generate and repair our tissues, such as those that reside
- [Sodium Rutin Extends Lifespan 10% in Mice](https://www.nmn.com/news/sodium-rutin-extends-lifespan-mice) - Highlights · Sodium rutin treatment extended the life and healthspan of mice. · The present findings suggest sodium rutin is a promising candidate for clinical application in age-related diseases. Since aging is linked to progressive dysregulation of our metabolism, the maintenance of metabolic health may lead to anti-aging effects. Lifespan-extending strategies, such as
- [Fisetin Reduces Coronavirus-Related Mortality in Old Mice](https://www.nmn.com/news/fisetin-reduces-coronavirus-related-mortality-mice) - Highlights · Aged, non-proliferating (senescent) cell burden in old mice confers the reduced lifespan observed following exposure to new viral pathogens. · Both pharmacological and genetic clearance of senescent cells yielded significant delay or reduction in mortality in both old male and female mice. The COVID-19 pandemic has revealed
- [New Study Suggests Fish Oil Nutrient May Slow Human Aging](https://www.nmn.com/news/fish-oil-nutrient-human-aging) - Highlights · A fish oil nutrient called omega-3 buffers against changing levels of markers for accelerated aging.· Supplementation with Omega-3 may reduce inflammation and the stress hormone cortisol response that can facilitate age-related diseases like heart ailments.· Omega-3 usage may also preserve DNA and chromosome health for healthy aging. If you take
- [Ginseng-Derived Compound Promotes Brain Blood Vessel Formation After Stroke](https://www.nmn.com/news/ginseng-derived-compound-promotes-brain-blood-vessel-formation-after-stroke) - Highlights · A ginseng-derived compound called notoginsenoside R1 significantly restored blood flow and promoted blood vessel formation in the brain post-stroke in mice.· Notoginsenoside R1 triggers a signaling cascade that increases levels of the bioenergetic molecule NAD+.· This signaling cascade improves energy metabolism in the brain
- [New Aging Tool Identifies Limit to Human Lifespan at 150 Years](https://www.nmn.com/news/new-aging-tool-identifies-limit-to-human-lifespan-at-150-years) - Highlights · A new method predicts how biological age affects resilience — the rate of recovery from setbacks in health.· This model was used to develop a biological sensor phone app to monitor people’s state of health and resilience to measure possible anti-aging effects of therapeutics. Our chronological age,
- [Intermittent Fasting Enhances Long-Term Memory and Adult Neurogenesis in Mice](https://www.nmn.com/news/intermittent-fasting-enhances-long-term-memory-and-adult-neurogenesis-in-mice) - Highlights · Intermittent fasting is more effective than calorie restriction in promoting long-term memory retention and increasing the generation of new brain cells in adult mice.· The longevity gene Klotho is upregulated by intermittent fasting and is required for neurogenesis in the mice and cultured human adult brain stem
- [Researchers Substantially Extend Mouse Lifespan by Activating NAD+-Dependent and Energy Balancing Enzyme](https://www.nmn.com/news/researchers-substantially-extend-mouse-lifespan-by-activating-nad-dependent-and-energy-balancing-enzyme) - Highlights · Mice genetically modified to overproduce SIRT6 protein see drastic increases in lifespan and physical performance.· SIRT6 improves liver cell energy and glucose sugar production for improved physical activity, healthspan, and survival. The rising aging global population, referred to as the “Silver Wave,” presents health-related challenges that include
- [Can Organ Transplantation Help You Live Forever?](https://www.nmn.com/news/can-organ-transplantation-help-you-live-forever) - In the dystopian movie The Island starring Ewan McGregor and Scarlett Johansson, clones of regular people are grown as a source of replacement body parts for ailing DNA-matched clients — wealthy people willing to pay large sums of money to extend their lifespans. Ethics aside, this premise begs the question: Can we live forever if
- [Scientists Reliably Predict Age by Measuring Blood Proteins](https://www.nmn.com/news/scientists-reliably-predict-age-by-measuring-blood-proteins) - Highlights · Protein levels in people’s blood can predict their age· Aging isn’t a smoothly continuous process. Through some Frankenstein-like experiments of exchanging blood between young and old animals, scientists have thought for some time that age-related changes of compounds in blood could provide new insights into age-related disease biology. After all, aging
- [Drops in NAD+ Levels Are Tied to Brain Damage Following Seizures](https://www.nmn.com/news/nad-levels-brain-damage-seizures) - Highlights · The levels of CD38, an NAD+ consuming enzyme, increase in brain cells during epilepsy.· CD38 emerges as an interesting new target in epilepsy. With spontaneous recurrent seizure activity — a condition called epilepsy — people can develop brain damage due to the over-stimulation of brain cells. Essentially, your brain cells get
- [Is Fisetin the Lifespan Extending Compound You’ve Been Looking For?](https://www.nmn.com/news/is-fisetin-the-lifespan-extending-compound-youve-been-looking-for) - Many efforts have been made on researching potential agents that target aging and age-related diseases. Among the popularly investigated agents are natural products like plant-based compounds. One promising example is fisetin — a micronutrient (polyphenol) with varying pharmacological properties that shows promising activity towards aging and age-related diseases. So, what is fisetin, what’s known about
- [Extremely Long-Lived Fish May Hold Key to Beat Aging](https://www.nmn.com/news/extremely-long-lived-fish-show-no-evidence-of-aging) - Highlights - North American freshwater fish called Bigmouth buffalo can live over a century. - Older bigmouth buffalo have improved immune function compared to younger fish. - There is no link between biological aging markers and chronological age in bigmouth buffalo. What would it be like to get older without aging? That’s where long-lived bony
- [Dr. Dudley Lamming on Dietary Restriction of Branch Chain Amino Acids Extending Male Mouse Lifespan](https://www.nmn.com/news/dr-dudley-lamming) - Welcome to the NMN.com podcast. I’m your host, Brett Weiss, and today we have Professor Dudley Lamming from the University of Wisconsin. Dr. Lamming has studied the effects of mouse dietary restrictions for specific protein building blocks called branch chain amino acids that stimulate a central regulator protein complex of metabolism and aging called the
- [Intermittent Fasting Improves Male Age-Related Frailty and Cognition](https://www.nmn.com/news/intermittent-fasting-improves-male-age-related-frailty-and-cognition) - Highlights Fasting every other day improves frailty measures including muscle function and cognition for aged male mice.Intermittent fasting also increases the production of a possible anti-aging chemical compound hydrogen sulfide in the kidney. As the global population over age 65 continues to grow, so too comes the need to extend the number of healthy years
- [Healthy Aging Linked to a Gut Bacteria Signature](https://www.nmn.com/news/healthy-aging-gut-bacteria-signature) - Highlights Elevated bacterial composition uniqueness predicts better health and survival in older ageSpecific age-related patterns of gut bacteria are linked to higher levels of blood metabolic byproducts like indoles that may contribute to healthy aging The types of microorganisms inhabiting the gut – the microbiome – change as people approach their later years. Whether these
- [NAD+ Improves Adult Stem Cells For Research and Clinical Applications](https://www.nmn.com/news/nad-improves-adult-stem-cells-research-clinical-applications) - Highlights Nicotinamide adenine dinucleotide (NAD+) replenishment significantly postpones the senescence of bone marrow-derived mesenchymal stem cells (BMSCs).NAD+ supplementation reduced cell levels of harmful oxygen-containing molecules called reactive oxygen species (ROS) in senescent BMSCs. Stem cells are found throughout our adult bodies that multiply to replenish dying cells and regenerate damaged tissues. One type known as
- [GlyNAC Improves Physical Functioning and Cognition in Older Adults](https://www.nmn.com/news/glynac-improves-physical-functioning-cognition-older-adults) - Highlights · Older adults supplementing with the glutathione antioxidant precursor combination GlyNAC reduces cellular stress. · GlyNAC supplementation also improves physical functioning, muscle strength, inflammation, and cognition in older adults. Getting older typically involves physical and cognitive decline as well as a diminished quality of life. At the root of
- [The First Non-Invasive Indicator to Evaluate Drugs that Target Aging Cells](https://www.nmn.com/news/the-first-non-invasive-indicator-to-evaluate-drugs-that-target-aging-cells) - Highlights · Non-replicated cells linked to aging make several bioactive fat molecules, including a type called prostoglandins · One specific prostoglandin called dihomo-15d-PGJ2 is released when these non-replicating cells are destroyed The hunt for anti-aging drugs has been continuously gaining steam. One major approach to prevent aging has been
- [NAD+ Boosting Nanocrystals Protect Mouse Hearts from Damage](https://www.nmn.com/news/nad-boosting-nanocrystals-protect-mouse-hearts) - Highlights · Nanocrystals containing nicotinamide riboside (NR) and resveratrol boost NAD+ levels in multiple mouse organs. · These nanocrystals attenuate heart damage and dysfunction after injury in mice. Nicotinamide riboside (NR), as a dietary supplement, can be converted to nicotinamide adenine dinucleotide (NAD+) in cells to support metabolism and
- [NAD+ Supplementation Improves Liver Regeneration](https://www.nmn.com/news/nad-supplementation-improves-liver-regeneration) - Highlights · Loss of the mitochondrial sirtuin SIRT3 impairs liver regeneration after partial liver removal. · The NAD+ precursor nicotinamide riboside can regenerate the liver independent of SIRT3. Our livers are constantly fighting off damage. To win this war and keep our body metabolism running properly, liver cells lost due to acute injury
- [Fisetin Rescues Mice Brains Against Brain Inflammation-Induced Cognitive Impairment](https://www.nmn.com/news/fisetin-rescues-mice-brains-against-brain-inflammation-induced-memory-impairment) - Highlights · Fisetin has neuroprotective effects in mice with memory dysfunction caused by oxidative stress and brain inflammation.· Fisetin has antioxidant and anti-inflammatory qualities that improve brain cell connections and cognitive abilities. Several studies have indicated that oxidative stress, when cells have elevated levels of harmful molecules called reactive oxygen species (ROS), is
- [NIH Scientists Propose Strategy for Propelling Anti-Aging Research and Therapeutics](https://www.nmn.com/news/anti-aging-research-therapeutics) - Getting a handle on what leads to cellular senescence — an irreversible state where cells no longer proliferate — may provide scientists with a means to craft a blueprint of human aging. On the one hand, researchers have recognized the biological relevance of cellular senescence in age-related disease conditions like kidney dysfunction, neurodegeneration, and accumulated
- [Drug Combo Kills Off Aged Cells to Mitigate Spinal Disc Degeneration](https://www.nmn.com/news/drug-combo-kills-off-aged-cells-to-mitigate-spinal-disc-degeneration) - Highlights Dasatinib and Quercetin target aged, non-proliferating cellsTreating mice with these two drugs mitigates age-related spinal disc degenerationIf these results translate to humans, Dasatinib and Quercetin could provide a means to alleviate age-related lower back pain Many people experience lower back pain as they age, and the few clinical interventions that do exist like surgery
- [New Target for Non-Replicating Cells Improves Various Age-Associated Disorders](https://www.nmn.com/news/new-target-for-non-replicating-cells-improves-various-age-associated-disorders) - Highlights Metabolism of the protein building block glutamine is essential for the survival of non-replicating, growth-arrested human cells termed senescent.Inhibition of glutamine metabolism induces the death of senescent cells and ameliorates aging-related organ dysfunction in mice. Senescent cells — those that no longer replicate or grow — accumulate as we grow older and are linked
- [Quercetin Improves Poor Diet-Induced Heart Dysfunction](https://www.nmn.com/news/quercetin-improves-poor-diet-induced-heart-dysfunction) - Highlights · Quercetin stimulates improved heart function in cardiometabolic disease by promoting blood vessel generation. · Improved blood vessel integrity plays a key role in quercetin’s beneficial effects for heart function. · Quercetin’s positive impact isn’t related to aged cell elimination. We all know that eating a balanced diet contributes to our
- [Clearing Aged Non-Replicating Cells Alleviates Cognitive Impairment in Mice](https://www.nmn.com/news/clearing-aged-non-replicating-cells-alleviates-cognitive-impairment-mice) - Highlights · Brain inflammation contributes to brain aging and cognitive impairment.· Limiting brain inflammation by eliminating aged, non-replicating cells alleviates age-associated cognitive impairment in mice. Senescence, the phenomenon of when cells get locked into irreversible replication arrest, plays a key role in aging. Clearance of senescent cells has been shown to improve brain
- [The Benefits of Exercise for Seniors and Activities to Get Started](https://www.nmn.com/news/benefits-exercise-seniors-activities) - It’s hard to get into and stick to an exercise regimen, especially the older we get. That’s because we encounter more barriers to exercise with age. For example, many older adults aren’t active due to physical barriers such as discomfort, pain, and low energy. There are barriers that are more mental, such as the fear
- [NAD+ Levels Delay Facial Nerve Degeneration After Trauma](https://www.nmn.com/news/nad-levels-delay-facial-nerve-degeneration-after-trauma) - Highlights Following facial nerve injury, neurodegeneration and neuroinflammation are suppressed in mice lacking an enzyme that depletes levels of the bioenergetic compound NAD+.Supplementation of an NAD+ precursor slowed the nerve projection degeneration in mice with facial nerve injury. Facial muscles make all kinds of motions, often to convey emotion. The nerves that control these muscles
- [NAD+ Precursor Improves Cognition of Mice with Compromised Brain Blood Flow](https://www.nmn.com/news/nad-precursor-improves-cognition-mice-compromised-brain-blood-flow) - Highlights Treatment with the NAD+ precursor nicotinamide reduces brain damage in a diminished brain blood flow condition called chronic cerebral hypoperfusion (CCH).Nicotinamide administration also improves cognition in CCH mice. A constant supply of blood is needed to fuel the brain’s many essential functions. When we experience reduced brain blood supply over an extended time, a condition
- [Apigenin Ameliorates Kidney Injury in Diabetic Rats](https://www.nmn.com/news/apigenin-ameliorates-kidney-injury-diabetic-rats) - Highlights CD38 levels are increased in the damaged kidneys of diabetic ratsApigenin, an inhibitor of CD38, has antioxidant properties that mitigate diabetes-induced kidney injury Diabetic kidney disease is a serious diabetes-related complication and the leading cause of end-stage kidney disease. Since this kidney damage, often found in type 2 diabetes patients, is induced by multiple
- [Parasitic Worm Secretion Promotes Lifespan Sex-Specifically](https://www.nmn.com/news/parasitic-worm-secretion-promotes-lifespan-sex-specifically) - Highlights Parasitic worm secretion molecule ES-62 substantially extends male mouse lifespan but not female.ES-62 improves male mouse gut health, which may contribute to lifespan extension. Parasitic worms called helminths infect people’s intestines when their eggs get transmitted through contaminated food or water. And there’s an interesting link between age-related diseases associated with high calorie, Western
- [A Combination Treatment Has Promising Effects In ALS Patients](https://www.nmn.com/news/nicotinamide-riboside-pterostilbene-effects-als) - Highlights This clinical trial tested the effects of EH301 — a combination of nicotinamide riboside (NR) and pterostilbene — in a small cohort of ALS patients.Several months of EH301 was shown to significantly slow the progression of ALS relative to placebo and even showed improvements in several key outcome measures. Amyotrophic lateral sclerosis (ALS), or
- [Human Cells Exposed to an NAD+ Precursor Have Different Survival Responses](https://www.nmn.com/news/human-cells-nrh) - Highlights Dihydronicotinamide riboside (NRH) exposure results in different toxic responses between cultured human cells.NAD+ increases can cause cellular dysfunction and eventually induce cell death in certain cell types. Nicotinamide adenine dinucleotide (NAD+) is involved in processes that are intimately implicated in cell metabolism and aging. Our bodies are dependent on stable levels of NAD+, as
- [Study Proposes Prevention Strategy  for Multi-Organ Fibrosis](https://www.nmn.com/news/boosting-nad-may-prevent-multi-organ-fibrosis) - Highlights An NAD+ consuming enzyme CD38 is elevated in an autoimmune disorder called systemic sclerosisIncreased levels of CD38 are linked to augmented scarring and thickening of tissue in fibrotic responsesNAD+ boosting prevents multi-organ fibrosis Our understanding of the causes of autoimmune disorders like systemic sclerosis -- where the immune system attacks the body, leading to
- [Stanford Scientists Reverse Cognitive Aging in Mice by Revamping Immune Cells](https://www.nmn.com/news/stanford-scientists-reverse-cognitive-aging-in-mice-by-revamping-immune-cells) - Highlights Blocking a prostaglandin signaling pathway in aged immune cells reprograms their metabolism to a youthful state.The metabolic rejuvenation of these immune cells restores aged mouse cognition. Scientists have long considered that reversing age-related inflammation of the nervous system, or neuroinflammation, could slow cognitive aging processes and delay the onset of conditions like Alzheimer’s disease.
- [Can Pre-Workout NR  Alter Human Metabolic Response to Endurance Exercise?](https://www.nmn.com/news/pre-workout-nr-does-not-alter-human-metabolic-response-to-endurance-exercise) - Highlights One week of nicotinamide riboside (NR) supplementation doesn’t enhance human skeletal muscle metabolic adaptation before, during, or after endurance exercise.Signaling pathways sensitive to NAD+ in human skeletal muscle are not affected by this acute NR treatment either while working out for one hour, at rest, or in recovery. The way our bodies turn food
- [Protein Dietary Restrictions Show Health and Sex-Specific Lifespan Benefits in Mice](https://www.nmn.com/news/protein-dietary-restrictions-show-health-sex-specific-lifespan-benefits-mice) - Highlights · Diets low in specific protein components (branch-chain amino acids leucine, isoleucine, and valine) extend premature aging mouse lifespan. · Lifelong low branch-chain amino acid diets significantly increase the lifespan of healthy male mice but not female. Dietary protein restrictions promote longevity in experimental animal species like mice
- [NMN Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers](https://www.nmn.com/news/nmn-reduces-metabolic-impairment-male-mouse-offspring-obese-mothers) - Highlights Acute NMN treatment improved impaired glucose tolerance due to maternal and post-weaning high-fat diet.Short-term NMN treatment reduced liver lipid accumulation in regular and high-fat diet-fed offspring of obese mothers. Extensive evidence links increased maternal obesity to adverse offspring metabolic and cardiovascular outcomes, with increased risk for obesity and metabolic disease like non-alcoholic fatty liver
- [The Science Behind Adele’s Weight Loss](https://www.nmn.com/news/the-science-behind-adeles-weight-loss) - It’s common knowledge that health and longevity go hand in hand with diet, which has encouraged many people to pay close attention to what they eat. Although restricting calorie intake and fasting are proven methods to promote weight loss and longevity, it's not an easy or exciting thing to do every day. But wouldn’t it
- [An Ancient Therapeutic Compound Improves Energy Production in Aged Muscle](https://www.nmn.com/news/an-ancient-therapeutic-compound-improves-energy-production-in-aged-muscle) - When people reach their 40s, muscle mass and strength begin to decline, and up to 50% of muscle mass is lost by the time people reach their 80s. This decline leads to sarcopenia, a syndrome of progressive loss of muscle and strength that is a leading cause for reduced function and loss of independence in
- [Surfaces Enzymes of Immune Cells Deplete NMN and NAD+ During Aging](https://www.nmn.com/news/enzymes-immune-cells-nmn-nad-during-aging) - The vital compound nicotinamide adenine dinucleotide (NAD+) binds to enzymes in cells involved in reactions that generate energy for the body and enzymes called PARPs and sirtuins to maintain the health of cells. Levels of NAD+ decline with age, which contributes to the dysfunction of life-sustaining chemical reactions (metabolism) and reduced overall physical fitness, but
- [Neuroscientists Revive Memory Deficits and Brain Cell Loss in Diabetic Rats](https://www.nmn.com/news/neuroscientists-revive-memory-deficits-and-brain-cell-loss-in-diabetic-rats) - The brains of many people with diabetes often undergo changes that are hallmarks of Alzheimer's disease and dementia. Diabetes patients with cognitive dysfunction—the loss of intellectual functions like thinking, remembering, and reasoning severe enough to interfere with day-to-day living—typically have damage to nerve cells, supportive brain cells, and blood vessels in the brain, causing them
- [Increased NAD+ Promotes Sensitivity to Anti-Cancer Therapy](https://www.nmn.com/news/nad-metabolism-promotes-tumor-development-and-sensitivity-to-anti-cancer-therapy) - All cells need nicotinamide adenine dinucleotide (NAD), a bioenergetic molecule, to carry out essential functions and for survival. But NAD+ production (biosynthesis) is often elevated in human cancers, where it plays a critical role in the initiation, progression, and relapse of tumors. Yet, how NAD+ metabolism — the chemical reactions that make, process, and use
- [Phase I Trial Results Show Safety of Nicotinamide-Expanded Donor-Derived Natural Killer Cells in Blood Cancers](https://www.nmn.com/news/phase-i-trial-results-show-safety-of-nicotinamide-expanded-donor-derived-natural-killer-cells) - Cell-based therapies take cells and inject, graft, or implant them into a patient for a medicinal effect. They are recognized for their tremendous potential to provide curative treatment options for patients with blood cancers and rare, serious blood disorders. One potential candidate for cell-based therapies is an immune cell type called natural killer cells that
- [Understanding the Long-Term Effects of Childhood Trauma](https://www.nmn.com/news/understanding-the-long-term-effects-of-childhood-trauma) - “Child abuse casts a shadow the length of a lifetime.” – Herbert Ward Childhood trauma is a horrific experience that can affect a child’s mental and physical health for years to come—even into adulthood. It is also a grave psychosocial, medical, and public policy problem that has serious consequences, not only for its victims, but
- [A Nutrition Guide for Memory Loss Care and Prevention](https://www.nmn.com/news/senior-nutrition-guide) - Preface Memory problems are a major issue facing senior adults in the United States. In fact, as many as 40% of U.S. adults over the age of 65 experience memory impairments as they age. On top of being inconvenient or frustrating, memory loss can have a variety of health consequences, ranging from minor issues to
- [The Molecules SS-31 and NMN Synergistically Improve Aged Heart Function](https://www.nmn.com/news/two-molecules-improve-heart-function) - Cardiovascular disease is a major cause of death in older people, with greater mortality than all types of cancer in adults older than 75 years of age combined. When heart function declines with age, phases of the heartbeat get disrupted--specifically, when the heart fills with and pumps out blood. Due to the mortality rate from
- [Research Reveals NMN Improves Depression in Mice](https://www.nmn.com/news/nmn-improves-depression-symptoms) - About 16.2 million US adults, about 7% of the population, had at least one major depressive episode in the year 2016, according to the National Institute of Mental Health (NIMH). Although doctors can prescribe antidepressant medications to treat depression, about two-thirds of people with depression don’t respond to initial treatments. About 15%-40% do not respond
- [Enzyme-Mediated NAD+ Production is Essential for the Quality Control of Aged Eggs](https://www.nmn.com/news/enzyme-mediated-nad-production-essential-quality-control-aged-eggs) - The number of eggs in a woman is set before she's born. As a fetus in its mother's womb, females have about 6 million to 7 million eggs. From then on, the number of eggs only drops. At birth, the baby girl has approximately 1 million eggs, when she hits puberty, about 300,000 remain. Not
- [Recent Research Suggests NMN Supplementation Improves Brain Function in Aging](https://www.nmn.com/news/recent-research-suggests-nmn-supplementation-improves-brain-function-in-aging) - Scientists from the University of Oklahoma Health Sciences Center conduct a study providing evidence nicotinamide mononucleotide (NMN) administration improves brain function in aged mice. The data suggest NMN administration improves brain blood vessel dilation (vasodilation) and blood flow to the brain, improving cognitive function. Scientists from the University of Oklahoma Health Sciences Center studying NMN
- [NAD+ Regulates Specific Protein Interactions that may Protect the Cell from DNA damage](https://www.nmn.com/news/nad-regulates-protein-interactions-that-may-protect-the-cell-from-dna-damage) - Scientists from Harvard Medical School made a discovery so interesting that it attracted the attention of NASA. The study published in Science could lead to a drug for reversing aging and improving DNA repair, even helping NASA get astronauts to Mars. The ability of cells to repair DNA declines as we age, allowing damage to
- [Scientists Demonstrate NMN Limits Liver Damage with Alcohol Consumption in Mice](https://www.nmn.com/news/nad-boosting-nmn-may-limit-lowered-nad-levels-and-liver-damage-in-chronic-alcohol-consumption-and-alcoholic-liver-disease) - A paper published in Human Genomics on December 10, 2019, described how the nicotinamide adenine dinucleotide (NAD+) boosting supplement nicotinamide mononucleotide (NMN) works to treat liver disease caused by alcohol consumption in mice. The team of scientists embarked on this study because chronic alcohol consumption has contributed significantly to liver disease worldwide. The resulting alcoholic
- [Scientists Improve Bone Formation Deficiencies in Glucocorticoid-Induced Osteoporosis](https://www.nmn.com/news/scientists-at-nanchang-university-improve-bone-formation-deficiencies-in-glucocorticoid-induced-osteoporosis) - Of the major side effects from glucocorticoid-induced osteoporosis, bone fractures are among the most devastating, affecting 30-50% of patients diagnosed with osteoporosis. Clinicians use glucocorticoids, such as dexamethasone and hydrocortisone to treat patients with inflammation, immunological rejection of transplanted tissue, and autoimmune diseases. In glucocorticoid-induced osteoporosis, patients have “porous bone” when viewed under a microscope,
- [Scientists Improve Muscle Development in Zebrafish with Neuromuscular Disease](https://www.nmn.com/news/scientists-improve-muscle-development-zebrafish-neuromuscular-disease) - Dystroglycanopathies represent forms of muscular dystrophy, which present as severe mental retardation and brain and eye malformations. The rare genetic disorder results in muscle development abnormalities and can be lethal. Scientists from the University of Maine published a study in Skeletal Muscle where they found supplementing with a molecule called nicotinamide adenine dinucleotide (NAD+) improved
- [NAD+ Increases Healthspan and Lifespan Through DNA Repair in Animals with Neurological Defects](https://www.nmn.com/news/nad-healthspan-lifespan-dna-repair-animals) - Ataxia telangiectasia (A-T) is a rare genetic disease consisting of uncoordinated movement, sensitivity to radiation, and atrophy of a region of the brain called the cerebellum. The disease presents in individuals who inherit a pair of defective genes, one from each parent. The gene Ataxia-Telangiectasia Mutated (ATM) regulates cell growth and division under normal circumstances,
- [NMN Improves Telomere Length and Liver Damage in Mice](https://www.nmn.com/news/nmn-supplementation-may-improve-conditions-associated-with-reduced-dna-integrity) - Highlights -Dysfunction of protective caps at the ends of chromosomes called telomeres is linked to a steep decline in NAD+. -Increasing NAD+ levels with NMN stabilizes telomeres and improves liver fibrosis. DNA on ends of chromosomes that shorten with age called telomeres are involved in many conditions, including premature aging. But how exactly this happens and
- [Neuroprotective Chemicals Prevent Neurodegeneration and Preserve Function After Traumatic Brain Injury](https://www.nmn.com/news/neuroprotective-chemicals-prevent-neurodegeneration-and-preserve-function-after-traumatic-brain-injury) - On the afternoon of August 4, 2020, grey smoke with white flashes rumbled into the air at the port of Beirut. At 6:09 p.m., an explosion sent a powerful shockwave throughout the seaside city, shattering glasses, stripping away walls, exposing the rebars -- skinning the buildings naked. The blast left hundreds dead and thousands injured.
- [NMN Protects Against Corneal Cell Death in Damaged Eyes](https://www.nmn.com/news/replenishing-nad-eye-may-treat-corneal-cell-death) - Our window to the world is the cornea, a transparent dome-like layer of cells that sits directly on top of our iris and pupil, allowing light to enter the eyes and enabling us to see the orange hues at sunrise, the 50 shades of blue in the ocean and our loved ones' smiles. That window
- [Blood Enzyme from Young Mice Delays Aging and Extends Lifespan in Aged Mice](https://www.nmn.com/news/enzyme-in-blood-from-young-mice-helps-delays-aging-and-extends-lifespan-in-aged-mice) - (Credit: Mitsukuni Yoshida | Washington University School of Medicine) The video shows an active mouse supplemented with eNAMPT and a less active mouse given saline. Gas runs low for a car after traveling a certain number of miles, and as organisms age, the fuel for our body does, too. One can compare this physiological gas
- [Scientists Demonstrate Increasing NAD+ Levels Restores Mitochondrial Function and Limits Aging](https://www.nmn.com/news/scientists-demonstrate-increasing-nad-levels-restores-mitochondrial-function-and-limits-aging) - A study led by Hilde Nilsen and Vilhelm A. Bohr of University of Oslo, Norway and University of Copenhagen, Denmark, respectively, along with scientists from the National Institutes of Health in Baltimore, Maryland, USA, presents data showing nicotinamide adenine dinucleotide (NAD+) restoration limits mitochondrial dysfunction and aging in Werner syndrome. Studies indicate a cellular process
- [NMN and Female Fertility During Aging](https://www.nmn.com/news/nmn-and-female-fertility-during-aging) - Scientists from UNSW Sydney and the University of Queensland in Australia, along with David A. Sinclair from Harvard, demonstrate elevation of nicotinamide adenine dinucleotide (NAD+) levels may provide an effective and non-invasive strategy to restore and maintain female fertility during aging. The scientists use the NAD+ precursor, nicotinamide mononucleotide (NMN), to restore NAD+ levels in
- [NMN Increases Maternal Egg Quality, Number, and Fertilization Ability](https://www.nmn.com/news/nmn-oocyte-quality-and-fertilization-ability) - An oocyte is the very beginning of human life—in the simplest of terms, it is an immature egg cell that eventually matures and becomes an ovum, or egg. However, as women age, there is a decline in oocyte quality, and effective approaches to improve oocyte quality remain sparse. A study in Cell Reports found that
- [Boosting NAD+ Levels Improves Heart Function in Mice with Heart Failure](https://www.nmn.com/news/boosting-nad-levels-improves-heart-function-in-mice-with-heart-failure) - Approximately 6.5 million people in the United States had heart failure in 2019, and heart failure contributed to 1 in 8 deaths in 2017. The condition cost the nation an estimated $30.7 billion in 2012. In 2017, scientists from Duke University found that a molecule called nicotinamide mononucleotide (NMN) had therapeutic efficacy in mice with
- [NAD+ Boosting Molecule Protects Mice from Hearing Loss](https://www.nmn.com/news/nad-boosting-molecule-protects-mice-from-hearing-loss) - Noise exposure constitutes a major cause of hearing loss throughout the world. It causes cellular degeneration in the cochlea, a structure of the inner ear that responds to sound vibrations. In this structure, hair cells connected to nerve fibers called spiral ganglia nerve fibers, convey sound information from the cochlea to the brain. With intense
- [NAD+ is Essential for Vision in Mice](https://www.nmn.com/news/nad-essential-for-vision-mice) - Your eye is a piece of delicate machinery that allows you to appreciate the scenery and detect danger from the world. In healthy individuals, light enters the pupil and lands on the retina at the back of our eye, forming images. How the Retina Enables Vision The retina is composed of two kinds of photoreceptors:
- [Boosting NAD+ Improves Mitochondrial Health Following Cerebral Ischemia](https://www.nmn.com/news/boosting-nad-improves-mitochondrial-health-following-cerebral-ischemia) - Cerebral ischemia is defined by inadequate blood supply to neural tissue leading to an oxygen shortage. A person will lose consciousness after 10 seconds of interrupted blood flow to the brain, and other symptoms of cerebral ischemia include impairments in vision, body movement, and speaking abilities. Previous research has indicated treating mice with a molecule
- [NMN Ameliorates Gut Aging in Mice](https://www.nmn.com/news/nmn-ameliorates-age-induced-changes-in-intestinal-stem-cells-of-mice) - The ability of stem cells to self-renew and differentiate into mature cells is crucial for tissue maintenance and healing in response to injuries. Stem cells persist in the body throughout one’s lifetime, which makes them susceptible to cellular damage that eventually results in cell death and loss of abilities to regenerate tissue, a process referred
- [NMN Protects the Brain: Preventing Neuronal Death and Improving Cognition](https://www.nmn.com/news/nmn-protects-the-central-nervous-system-preventing-neuronal-death-and-improving-cognition) - In 2060, projections forecast the number of people with Alzheimer’s disease in the US will grow to 13.9 million people, which more than doubles the number in 2018, according to the Centers for Disease Control and Prevention (CDC). Although the world is growing older and the population of Alzheimer’s disease patients is increasing, currently, there
- [NMN Promotes Brain Blood Vessel Rejuvenation in Aged Mice](https://www.nmn.com/news/nmn-treatment-promotes-brain-blood-vessel-rejuvenation) - Imagine during your older years walking out to your car and realizing you forgot your car keys. Lapses in memory like this can result from miscommunication and dysfunction of neurons and blood vessels of the brain, which constitute what neuroscientists call the neurovascular unit. This blood-supplying apparatus functions to distribute nutrients to neurons. However, the
- [A Therapeutic Approach to Falling NAD+ Levels After Brain Injury](https://www.nmn.com/news/a-therapeutic-approach-to-falling-nad-levels-after-brain-injury) - Following brain injury and during the progression of neurodegenerative diseases, the major power-generating components of the cell, the mitochondria, release reactive molecules known as free radicals that can cause further cellular damage. Recently, scientists from the University of Maryland published a review in Brain Sciences where they elaborated on a possible molecular mechanism whereby mitochondria
- [NMN  Protects Mouse Hearts from Failure](https://www.nmn.com/news/nmn-administration-promotes-mitochondrial-health-and-prevents-heart-failure) - Approximately 647,000 people die from heart disease each year in the US, which equates to 1 in every 4 deaths. In the years 2014 and 2015, heart disease cost the United States about $219 billion each year, which includes costs from health care services, medicines, and lost productivity due to death. Finding therapeutic interventions in
- [Clinical Trial Shows Safety of NMN in Humans](https://www.nmn.com/news/results-of-first-human-study-of-nmn-administration-reveal-no-safety-concerns) - The average human lifespan worldwide has increased, leading to a massive increase in people with age-related diseases, such as cancer, cardiovascular disease, type 2 diabetes, high blood pressure (hypertension), and macular degeneration. In animal models, the administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the effectiveness, let alone safety, of
- [Study Indicates Why B3 Vitamin Improves Roundworm Lifespan but Not Human](https://www.nmn.com/news/scientists-show-evidence-for-why-nicotinic-acid-can-extend-lifespan-of-roundworm-c-elegans-and-not-human-cells) - Scientists from Taiwan have published a study showing that nicotinic acid, a form of Vitamin B3 the body metabolizes to nicotinamide adenine dinucleotide (NAD+), increased lifespan in the roundworm, C. elegans, but not lifespan of human Hs68 cells. The study demonstrated under normal circumstances in human Hs68 cells, levels of nicotinamide adenine dinucleotide (NAD+) in
- [NAD+ Alleviating Symptoms of Alzheimer's Disease in Mice](https://www.nmn.com/news/brian-dysfunctions-in-alzheimers-disease-decreased-linked-to-lower-nad-and-nmn-production-by-nampt-in-app-ps1-mice) - Research on Alzheimers Disease from the Shanghai Geriatric Institute of Chinese Medicine and Shanghai University of Traditional Chinese Medicine identified nicotinamide mononucleotide (NMN) synthesis as a principal step in disease progression. NMN is the number one precursor used to make an important coenzyme in the body, Nicotinamide Adenine Dinucleotide (NAD). NAD+ is a predominant co-enzyme
- [Tracking NAD+ Levels: From the Brain to Blood](https://www.nmn.com/news/measuring-nad-level-for-the-first-time) - Nicotinamide adenine dinucleotide (NAD+) levels decrease with age in rodent models. This reduction associates with age-related diseases, causing abnormalities in the nucleus and the powerhouse of cells, the mitochondria. Back in 2015, scientists from the University of Minnesota found these same reductions in NAD+ levels with age in humans for the first time. The published
- [Pharmacokinetics: The Missing Metric to Determine Dosage](https://www.nmn.com/news/pharmacokinetics-the-missing-metric-to-determine-dosage) - Very pure Nicotinamide Mononucleotide (NMN) is available as a supplement but scientists are still learning about the way in which it is absorbed utilized and excreted by our bodies. NMN is the precursor to a very important coenzyme, Nicotinamide Adenine Dinucleotide (NAD). NMN is thought to boost NAD levels, with some proposed benefits to cellular
- [NMN Mitigates the Effects of Age-Related Macular Degeneration](https://www.nmn.com/news/treating-age-related-macular-degeneration-by-improving-retinal-energy-production) - Age-related macular degeneration (AMD) constitutes the leading cause of vision loss in adults and affects 20-30% of people over 75 years of age in developed nations. Individuals with AMD have difficulties reading, recognizing faces, and visualizing fine detail. But current treatments for AMD can only treat about 10% of the patients, those with “wet” AMD,
- [Brain Structure Changes, Memory Quality, and Memory Storage in Aging](https://www.nmn.com/news/neuroscientists-studying-effects-of-aging-on-memory-provide-evidence-brain-structure-integrity-and-quality-of-acquired-memories-in-different-age-groups-affect-memory-formation-during-sleep) - Neuroscientists Studying Effects of Aging on Memory Provide Evidence Brain Structure Integrity and Quality of Acquired Memories in Different Age Groups Affect Memory Formation During Sleep Humans have two types of sleep: rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep. Different brainwaves (waveforms) and neural activity characterize these two types of sleep.
- [NMN May Prevent Vascular Cognitive Impairment](https://www.nmn.com/news/nmn-may-prevent-vascular-cognitive-impairment) - Scientists from the University of Oklahoma Health Sciences Center conduct a study demonstrating nicotinamide mononucleotide (NMN) supplements improve brain blood vessel generation (crebromicrovascular angiogenesis) in aged rats. The scientists also point to studies underway to determine whether long term treatment with another nicotinamide adenine dinucleotide (NAD+) precursor, nicotinamide riboside (NR), improves blood flow to the
- [Molecular Model of Restoration of Cognition in Aging](https://www.nmn.com/news/molecular-model-of-restoration-of-cognition-in-aging-with-nmn) - Scientists from Washington University School of Medicine in St. Louis, Missouri obtain data from a study to propose a model of age-related cognitive decline. According to the model, nicotinamide mononucleotide (NMN) consumption improves symptoms associated with age-related cognitive decline in mice. Finding ways to address age-related, cognitive health issues for improving quality of life has
- [NMN as Potential Therapeutic Agent for Neuromuscular Disease](https://www.nmn.com/news/nmn-as-potential-therapeutic-agent-for-muscle-disease) - Scientists from the University of Missouri report disruptions of the NAD+ biosynthesis pathway in mice facilitating malformed mitochondria and cell structure in muscle. Furthermore, nicotinamide mononucleotide (NMN) administration at least partially restores these cellular defects. Image from Lundt et al. (2020) Amyotrophic lateral sclerosis (ALS) constitutes a lethal motor neuron disease with degenerative changes in
- [NMN Anti-Aging Effect on MicroRNAs](https://www.nmn.com/news/nmn-anti-aging-effect-on-micrornas) - A study funded by the American Heart Association at Reynolds Oklahoma Center on Aging demonstrated mice treated with NMN for two weeks had different micro ribonucleic acid (microRNA or miRNA) 'fingerprints’. These miRNAs targeted genes for intracellular signalling, protein balance, and inflammation. The changes in miRNAs were tested in the main artery of the heart
- [NMN May Restore Bone Loss From Aluminum Toxicity](https://www.nmn.com/news/nmn-may-restore-bone-loss-from-aluminum-toxicity) - Aluminum, an environmental contaminant, can have toxic effects on the brain, bones, liver, and kidneys.4,8,11 Medicines, cosmetic products, and food additives can contain aluminum.8,10 Acid rain has also mobilized aluminum from soil, making aluminum exposure through water and food products more prevalent.4 Approximately 50-70% of aluminum entering the body accumulates in the bone, a primary
- [Scientists Identify Transporter for Cell Absorption of NMN in Mice](https://www.nmn.com/news/scientists-identify-nmn-transporter) - Nicotinamide mononucleotide (NMN) is a precursor that cells use to synthesize the essential molecule NAD+ and is proposed to counteract age-associated diseases and disorders associated with a decline in tissue NAD+ levels.1-14 But how NMN is taken up into cells has not been entirely clear. In a study published in Nature Metabolism, researchers from the
- [NMN Provides Heart Protection in Mice](https://www.nmn.com/news/nmn-provides-heart-protection-in-mice) - Activity of proteins, sirtuins, regulating metabolic health declines with age. Scientists have previously sought methods to increase sirtuin activity as people age including proposing the use of nutraceuticals, such as NMN, to improve symptoms of age-associated diseases.1,2 The role of other mechanisms through which NMN supplementation may confer improvements of age-related diseases have received less
- [The Science of Aging in Isolation](https://www.nmn.com/news/the-science-of-aging-in-isolation) - As COVID-19 spreads across the nation, college and university shut down non-essential in-lab research, sending scientists to “do science without a bench.”
- [NMN and Melatonin Can Improve Cognitive Impairment in Aged Rats](https://www.nmn.com/news/nmn-and-melatonin-can-improve-memory-in-aged-rats) - Cognitive deficits and impaired memory relate closely with age over time According to research, events such as apoptosis, cell death and damage to the mitochondria contribute significantly to age-related learning and memory deficits.3,4,5 Under such circumstances, free radicals which have excess atoms or molecules with unpaired electrons reduce levels of energy molecules, ATP. Alterations in
- [Researchers Propose NMN May Protect the Brain from Stroke Damage in Mice](https://www.nmn.com/news/nmn-protects-brain-tissue-in-intracerebral-hemorrhage-mouse-model) - Even with improvements in medical treatments in the past two decades, the needle has hardly moved for the mortality rate from intracerebral hemorrhage — an emergency condition in which a ruptured blood vessel causes bleeding inside the brain. Now, a research team from Shanghai Jiao Tong University shows that injections of nicotinamide mononucleotide (NMN) significantly
- [How Treating Aging Itself Might Help Overcome COVID-19](https://www.nmn.com/news/treating-aging-overcome-covid-19) - Spreading like wildfire in the cities, COVID-19 scorched the world with a pneumonia-like illness. Adults over 60, particularly those with underlying medical conditions, are more likely to have severe, even deadly, infections than other age groups. A new review paper published March 30 in the journal Aging proposed that targeting aging-related pathologies can be a
- [Aging Fits Disease Criteria Used by World Health Organization](https://www.nmn.com/news/aging-fits-disease-criteria-used-by-world-health-organization) - Aging meets World Health Organisation (WHO) criteria used for classifying conditions as diseases, according to a team of scientists from the International Longevity Alliance, the Biogerontology Research Foundation, and the Department of Risk Factor Prevention. An international team of gerontologists, or scientists who study aging, analysed how the aging process compared to criteria found in
- [Dual Decline in Memory and Walking Pace Signals Higher Dementia Risk in Elders](https://www.nmn.com/news/dual-decline-in-memory-and-walking-pace-signals-higher-dementia-risk-in-elders) - Foggy memory and slow walking speed, separately, are early signs for the risk of dementia. A recent study showed that the combination of memory and walking pace decline is even more blaring. The results published in JAMA Network Open, on Feb 5, suggest that individuals with dual decline can serve as valuable targets for preventive
- [Consuming Whey Protein Can Improve Elders’ Muscle Performance](https://www.nmn.com/news/consuming-whey-protein-can-improve-elders-muscle-performance) - Gerontologists, scientists who study aging, published a study in Experimental Gerontology indicating that whey protein supplements promote muscle performance in the elderly. If their results hold, whey protein supplements could offer a promising avenue for improving health of the elderly. Studies like these have gained importance with the increasing population of elderly individuals worldwide. Because
- [Scientists Discover Two Regulators that Could Halt Unhealthy Aging](https://www.nmn.com/news/scientists-discover-two-regulators-that-could-halt-unhealthy-aging) - During the 20th century, life expectancy in the U.S. had a 30-year increase, from 48 years to 77. But health doesn't always come with longevity. A team of Chinese scientists reported in Nature that two genetic regulators prevent healthy aging, and targeting them could mitigate age-related deterioration like Alzheimer's. "Compared with great progress in understanding
- [Exercise Reverses Aging's Effect by Awakening Muscle Stem Cells](https://www.nmn.com/news/exercise-reverses-agings-effect-awakening-muscle-stem-cells) - As people pass the 30-year-old benchmark, chances are they're already losing muscle. But a new study published in Nature Metabolism on April 13 found that a nightly jog on the running wheel for old mice reverses aging's effect on muscle stem cells and regenerates muscle tissue. "We've been very interested for a long time on
- [Small Molecules Discovered to Halt Cellular Aging](https://www.nmn.com/news/small-molecules-discovered-halt-cellular-aging) - Sitting at the end of strands of DNA, telomeres play a crucial role in cellular aging. Like the protective caps on shoelaces, telomeres safeguard our DNA from damages during cell division. Unfortunately, these caps shorten and fray as the cell ages, and our cells inevitably become frail and die. But researchers from Harvard University found
- [A Master Controller Protein Might Reveal Why Females Live Longer](https://www.nmn.com/news/protein-reveal-why-females-live-longer) - From pilot whales hunting squid in the ocean to domestic cats chasing lasers across the hallway, most females live longer than males in the animal kingdom. This is especially true in humans. Despite differences across culture and environment, there is near unanimity of data supporting female longevity superiority, and scientists want to know why. Researchers
- [Understanding Malnutrition in the Elders: Aging and Diet Leads to Molecular Changes in the Intestinal Lining](https://www.nmn.com/news/aging-diet-leads-to-molecular-changes) - The small intestine, a 20-foot-long coiled tube-like organ, has the important job of absorbing nutrients from what we eat and drink. As we age, the organ loses its structure and functionality, which may lead to malnutrition. Now, scientists discovered that molecular changes in the intestine's linings caused by aging and diet are one of the
- [An Injection of “New Blood” Rejuvenates Older Rats](https://www.nmn.com/news/an-injection-of-new-blood-rejuvenates-older-rats) - The transfer of young blood plasma to older rats can rejuvenate tissues and organs. Although it might sound like a sci-fi movie, a not-yet peer reviewed study, deposited online provided new evidence for this proposition. Transferring young blood plasma to older rats reduced markers of aging in their bodies, reversing the effect of aging by
- [Epigenetic Blood Markers Show the Pace at which We Age](https://www.nmn.com/news/epigenetic-blood-markers-show-the-pace-we-age) - An international team of scientists has developed a blood test that measures how fast we “age” at the cellular level. According to the researchers, this test can determine how experimental treatments and environmental changes might change one’s pace of aging. Biological vs Chronological Age Disease is often a product of aging. As we grow older,
- [NAD+ Supplementation Shows an Improvement of Body Composition in Clinical Trial](https://www.nmn.com/news/nr-supplementation-improvement-body-composition) - Nicotinamide adenine dinucleotide (NAD+), a linchpin to body function, is the most abundant molecule in metabolic reactions next to water, but its level decreases as we age. Studies have shown that replenishing NAD+ levels in animals with nicotinamide riboside (NR), an NAD+ booster, can promote health and even "reverse" the effects of aging. Now, a
- [A New Biomarker for Brain Changes Shows Promise in Early Diagnosis of Dementia and Traumatic Brain Injury](https://www.nmn.com/news/biomarker-brain-changes-shows-promise-early-diagnosis-of-dementia) - Blood pooling in the brain like stagnant water after a rainfall is problematic, to say the least. Scientists at Japan’s RIKEN Center for Biosystems Dynamics Research (BDR) now say that monitoring for this effect can allow for early treatment of conditions such as Alzheimer’s and idiopathic normal pressure hydrocephalus (iNPH), another type of dementia. Although
- [Boosting NAD+ Might Turn Back Our Biological Clock](https://www.nmn.com/news/boosting-nad-might-turn-back-biological-clock) - As time ticks by, our internal clock loses its pace and consistency, older adults often become tired in the early evenings and wake up early in the morning. In a new study published in the journal Molecular Cell, scientists show how they might counter the effects of aging and rewind our internal clock to a
- [Activating This Enzyme Could Repair Age-Associated DNA  Damage in Neurons and Improve Cognition](https://www.nmn.com/news/activating-enzyme-could-repair-age-associated-dna-damage) - BW Age-related cognitive decline from normal aging and Alzheimer’s disease continue to increase in prevalence. In 2014, an estimated 5 million people 65 years of age and older had Alzheimer’s disease in the US. This number is expected to increase to 14 million people by the year 2060. These numbers illustrate the importance of research
- [Analyzing Human Genetics Uncovers Clues to Longevity](https://www.nmn.com/news/analyzing-human-genetics-uncovers-clues-to-longevity) - Embedded in DNA, our genes determine biological traits from eye color and blood type to the risk of diseases. Now, in a study published in Nature Medicine, Japanese researchers discovered that individuals who have a genetic susceptibility to high blood pressure or obesity have a shorter lifespan. "The genetic code contains a lot of information,
- [Socializing is Crucial for Both Humans and Animals to Live a Long and Healthy Life](https://www.nmn.com/news/socializing-crucial-for-both-humans-animals-live-healthy-life) - It has been two months since local governments issued the stay-at-home order across the U.S. to protect the health of residents by slowing the spread of COVID-19. As government and healthcare experts urge citizens to implement social distancing, they also stress the importance of "staying connected while staying away." Socialization is not only crucial to
- [NMN Restores Cognition and Protects Neurons In Diabetic Rats](https://www.nmn.com/news/nmn-restores-cognition-and-protects-neurons-in-diabetes) - Diabetes increases a person's chance of experiencing cognitive decline. Scientists have linked this effect with decreased nicotinamide adenine dinucleotide (NAD+) levels in the brain. Researchers from the University of Maryland boosted NAD+ levels in diabetic rats with nicotinamide mononucleotide (NMN), which improved and prevented diabetes-induced cognitive impairments. The results were published in the International Journal
- [Eat Less and Live a Long Healthy Life? It Depends on Your Gene](https://www.nmn.com/news/eat-less-live-long-healthy-life) - Dietary restriction in decreasing calorie intake and intermittent diet has shown to add extra years and health to animals' lives. Many research holds the assumption that dietary restriction can slow aging and extend both lifespan and healthspan, the quantity and quality of life together. A study published in Current Biology analyzed genetically distinct strains of
- [Nicotinamide Mononucleotide Supplementation Extends the Healthspan in Mice](https://www.nmn.com/news/long-term-nmn-supplementation-extends-the-healthspan-in-mice) - In 2018, for the first time in history, the number of people aged 65 or older surpassed the number of children under five globally. Today's European babies are projected to live over 100 years old, along with over 5 million centenarians alive in Europe by the end of the 21st century. As people live longer
- [Small Molecule Enhancing NAD+ Levels Rejuvenates Muscles](https://www.nmn.com/news/small-molecule-enhancing-nad-levels-rejuvenates-muscles) - Previous research indicated reduced levels of the molecule, nicotinamide adenine dinucleotide (NAD+), in the body with age contribute to dysfunctional skeletal muscle metabolism and inhibited function of the muscle cell's powerhouse, the mitochondria. This leads to muscle degeneration and loss of muscle function with age, along with impaired muscle repair. With this in mind, scientists
- [NAD+ Supplementation Mitigates Age-Associated Metabolic Diseases like Diabetes](https://www.nmn.com/news/nad-supplementation-could-mitigate-age-associated-metabolic-diseases) - Metabolic disorders such as diabetes continue to increase worldwide with critical implications for the occurrence of life-threatening diseases, which include heart diseases, stroke, and cancer, all stemming from metabolic disorders. These disorders often come from obesity, which causes diabetes and high blood pressure, also called hypertension. Developing metabolic disorders relates to lifestyle choices and diet.
- [NMN Protects the Mouse Heart from Ischemia and Reperfusion Injury](https://www.nmn.com/news/nmn-protects-heart-from-ischemia-and-reperfusion-in-mice) - Ischemia and reperfusion (I/R) -- when blood stops flowing into the heart (ischemia) and then is followed by a rush of blood flooding into the heart (reperfusion) -- is a life-threatening event. The heart damage induced by I/R is an important cause of heart failure in patients. In a study on PLOS One, a group
- [NMN Reverse the Effects of Alzheimer’s Disease in Mice](https://www.nmn.com/news/nmn-reverses-the-effects-of-alzheimers-disease-in-mice) - An estimated 5.7 million Americans lived with Alzheimer’s disease in 2018, according to the Centers for Disease Control (CDC). Alzheimer’s disease can seriously affect one’s ability to perform daily activities and involves a deterioration in parts of the brain controlling thought, memory, and language. Although scientists don’t know the exact cause of the disease, they
- [NMN Reverses Vascular Dysfunction in Aging Mice](https://www.nmn.com/news/taking-nmn-reverses-vascular-dysfunction-from-aging-in-mice) - Cardiovascular diseases constitute the leading cause of mortality in developed countries, and advancing age is the primary risk factor for cardiovascular disease. Since the projections for number of older adults will likely at least double by 2050, age-related heart disease is now more than ever becoming an issue. Scientists from the University of Colorado published
- [NAD+ Precursor Stimulates the Production of Blood Cells](https://www.nmn.com/news/vitamin-b3-analog-stimulates-the-production-of-blood-cells) - Blood, which makes up about 8 percent of an average person's weight, plays a crucial role in delivering nutrients, carrying oxygen, transporting waste products and fighting pathogens. A rapid growth in abnormal blood cells that cannot carry out its duty leads to blood cancers that can be lethal, such as lymphoma and leukemia. Blood cancer
- [NMN Stimulates Bone Marrow Stem Cells to Form More Bone and Less Fat](https://www.nmn.com/news/nmn-stimulates-bone-marrow-stem-cells) - Two hundred and six bones prop up the framework of an adult human, protecting our vital organs, supporting our weight, and enabling our mobility. Inside the rigid surface layer of the organ are honeycomb-like holes. Our bone tissues break down and get continuously replenished. But as we get older, new bone formation can’t keep up
- [NAD+ Activates Proteins and Cellular Pathways to Promote Longevity](https://www.nmn.com/news/nad-activates-proteins-and-cellular-pathways-to-promote-longevity) - Nicotinamide adenine dinucleotide (NAD+) constitutes an essential molecule for cellular health involved in energy production in the powerhouse of cells, the mitochondria. At age 50, our cellular NAD+ levels are about half of what they were at 20. Reduced NAD+ levels with age can adversely affect the functioning of the cell’s powerhouse, the mitochondria, resulting
- [NMN Helps Reverse Diet and Age Induced Diabetes in Mice](https://www.nmn.com/news/nmn-helps-reverse-diet-and-age-induced-diabetes-mice) - More than 34 million Americans have diabetes, and about 90 to 95 percent of them have type 2 diabetes. In our modern sedentary lifestyle, type 2 diabetes has become an epidemic likely due to calorie-rich diets overwhelming our metabolic pathways. Researchers at Washington University School of Medicine in St. Louis reversed diet- and age-induced diabetes
- [Comparing Interventions for Obesity and Being Overweight](https://www.nmn.com/news/comparing-interventions-for-obesity-and-being-overweight-exercise-improves-muscle-health-and-nmn-treatment-targets-liver-function) - In 2016, more than 1.9 billion adults were overweight worldwide, and about 35 percent of them were obese, according to the World Health Organization (WHO). If the current growth rate of the overweight population continues, almost half of the global adult population will be overweight or obese by 2030, according to the McKinsey Global Institute.
- [Eating Less Reduces Plaque Buildup in Alzheimer’s Disease](https://www.nmn.com/news/eating-less-reduces-plaque-buildup-in-alzheimers-disease) - An estimated 5.8 million people aged 65 and older in the US live with Alzheimer’s disease in 2020, and an estimated 13.8 million people will have Alzheimer’s dementia by 2050. In the medical field, 50 percent of physicians believe the society is not ready for the growing prevalence of this disease. Scientists have been searching
- [Aging Might Be Reversible -- Fixing the Miscommunications in Cells with NAD+](https://www.nmn.com/news/aging-might-be-reversible-fixing-the-miscommunications-in-cells) - Our cells are like intricate machinery that rely on different components' cooperation and communication, especially between the central command center and the powerhouse -- the nucleus and mitochondria. Scientists at Harvard University discovered that the communication breakdown between the two organelles in mice leads to accelerated aging. On the bright side, it might be reversible
- [Functional and Traditional Training: Improved Strength in Aging Women](https://www.nmn.com/news/functional-and-traditional-training-improved-strength-in-aging-women) - A study reported functional training and traditional training exercise routines improved strength and agility in aging women when compared to stretching alone. The study provided evidence functional and traditional training regimens combated deleterious effects which come with aging. Functional Training Outperforms Traditional and Stretching Exercises in Elderly Women Researchers in Brazil showed functional exercise routines
- [ATP Boosting NAD Level For Health and Aging](https://www.nmn.com/news/atp-boosting-nad-level-for-health-and-aging) - Much of the attention given to restoration of NAD+ levels examine its role in activating sirtuins. Scientific research, though, demonstrates NAD+ supplementation not only has beneficial effects on aging through sirtuin activity but also a variety of age-related disorders through improvement of adenosine triphosphate (ATP) levels. ATP declines with age ATP is the main source
- [NAD+ and the Sleep-Wake Cycle](https://www.nmn.com/news/nad-and-the-sleep-wake-cycle) - Healthy aging requires maintaining a regular sleep schedule. Dysregulated sleep patterns contribute to poor aging and disease. Moreover, imbalances in genes and molecules involved in the sleep-wake cycle (circadian rhythm) contribute to onset of diseases. Image from Nakahata & Bessho (2016) In studies of mice, diseases associated with imbalances in genes and molecules of the
- [Theories of Aging](https://www.nmn.com/news/theories-of-aging) - Two categorizations of aging exist-- chronological and biological. Chronological aging entails the number of years an organism has lived, while biological aging relates to physiological alterations reflecting age such as markers of aging in DNA (epigenetic signature). While age predicted with biological measures, like ‘epigenetic signatures,’ typically correlate well with chronological age, variance between individual
- [Easy on the Calories, But Please Pass the Nutrients](https://www.nmn.com/news/easy-on-the-calories-but-please-pass-the-nutrients) - Food and medicine have an ancient and tightly interwoven relationship. Hippocrates of Kos, sometimes referred to as the Father of Medicine, supposedly said “Let food be thy medicine and medicine be thy food.” The link between health and a good diet might not come as a surprise, but did you know that our food needs
- [NMN Protects Brain Cell Survival and Cognitive Function From Severe Hypoglycemia](https://www.nmn.com/news/nmn-improves-neuronal-survival-and-protects-cognitive-function-after-severe-hypoglycemia) - The high-caloric, inactive modern lifestyle has pushed our metabolism beyond what it can handle. Over 34 million Americans have diabetes and 90 percent of those have type 2 diabetes, in which the body either resists the effects of insulin, sugar-regulating hormones, or doesn’t produce enough to maintain normal blood sugar levels. Now, Chinese researchers found

## Pages

- [Precursors](https://cms.nmn.com/precursors) - Nothing to see here. Only for grouping pages.
- [What is NMN?](https://cms.nmn.com/precursors/what-is-nmn) - What's NMN? Nicotinamide mononucleotide (NMN) is a naturally occurring molecule found in every living cell of all life forms. At the molecular level, it belongs to a class of molecules called nucleotides, the building blocks of RNA and DNA. Structurally, NMN is composed of three main chemical groups: a phosphate group, a ribose sugar, and
- [Nicotinamide Mononucleotide (NMN): Benefits, Side Effects & Dosage](https://cms.nmn.com/precursors/nmn-benefits-side-effects-dosage) - Thanks to advances in modern medicine, individuals around the world have been living longer. In addition to lower mortality and increased survival, a sustained drop in fertility has shifted the proportion of older individuals upwards. According to the World Health Organization, the world's population of older individuals is expected to reach 2.1 billion by 2050,
- [NMN vs NR: The Differences Between These 2 NAD+ Precursors](https://cms.nmn.com/precursors/nmn-vs-nr) - Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are biosynthetic precursors to an essential molecule for metabolism-- nicotinamide adenine dinucleotide (NAD+). Numerous studies indicate NAD+ levels decrease significantly during aging, with restoration of NAD+ levels in aged animals extending lifespan and promoting health. Research on the two molecules indicates supplementation with either increases NAD+ levels during aging. What
- [What Is NAD⁺? | Why Is It Important for Health  and Longevity?](https://cms.nmn.com/precursors/what-is-nad) - NAD⁺ stands for nicotinamide adenine dinucleotide. From single-cell organisms like bacteria to sophisticated multicellular ones like primates, NAD⁺ is one of the most abundant and crucial molecules. Basically, without NAD⁺, we would be on the fast track to death. The molecule is a linchpin to the function of the generators of cells -- mitochondria. NAD⁺

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- [Metformin](https://cms.nmn.com/news/tag/metformin)
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- [Silver Nanocrystals](https://cms.nmn.com/news/tag/silver-nanocrystals)
- [Glucose Clearance](https://cms.nmn.com/news/tag/glucose-clearance)
- [Bone Marrow Stem Cells](https://cms.nmn.com/news/tag/bone-marrow-stem-cells)
- [Dry Eye Disease](https://cms.nmn.com/news/tag/dry-eye-disease)
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- [Senolysis](https://cms.nmn.com/news/tag/senolysis)
- [Glutamine](https://cms.nmn.com/news/tag/glutamine)
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- [Muscle Function](https://cms.nmn.com/news/tag/muscle-function)
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- [Liver Regeneration](https://cms.nmn.com/news/tag/liver-regeneration)
- [Angiogenesis](https://cms.nmn.com/news/tag/angiogenesis)
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- [Autophagy](https://cms.nmn.com/news/tag/autophagy)
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- [Synapse](https://cms.nmn.com/news/tag/synapse)
- [Cardiovascular System](https://cms.nmn.com/news/tag/cardiovascular-system)
- [Heart Scarring](https://cms.nmn.com/news/tag/heart-scarring)
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- [Prostaglandins](https://cms.nmn.com/news/tag/prostaglandins)
- [Apoptosis](https://cms.nmn.com/news/tag/apoptosis)
- [Kidney Scarring](https://cms.nmn.com/news/tag/kidney-scarring)
- [Kidney Fibrosis](https://cms.nmn.com/news/tag/kidney-fibrosis)
- [Cell Viability](https://cms.nmn.com/news/tag/cell-viability)
- [Nanocrystals](https://cms.nmn.com/news/tag/nanocrystals)
- [Biological Aging](https://cms.nmn.com/news/tag/biological-aging)
- [Telomeres](https://cms.nmn.com/news/tag/telomeres)
- [Vascular Health](https://cms.nmn.com/news/tag/vascular-health)
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- [Chromosomes](https://cms.nmn.com/news/tag/chromosomes)
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- [Telomerase](https://cms.nmn.com/news/tag/telomerase)
- [Protein Signatures](https://cms.nmn.com/news/tag/protein-signatures)
- [Aging Clock](https://cms.nmn.com/news/tag/aging-clock)
- [Parabiosis](https://cms.nmn.com/news/tag/parabiosis)
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- [Transplantation](https://cms.nmn.com/news/tag/transplantation)
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- [Developmental Abnormalities](https://cms.nmn.com/news/tag/developmental-abnormalities)
- [Ghrelin](https://cms.nmn.com/news/tag/ghrelin)
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- [Skin Health](https://cms.nmn.com/news/tag/skin-health)
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- [Lifespan](https://cms.nmn.com/news/tag/lifespan)
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- [Gero](https://cms.nmn.com/news/tag/gero)
- [GeroSense](https://cms.nmn.com/news/tag/gerosense)
- [Caloric Restriction](https://cms.nmn.com/news/tag/caloric-restriction)
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- [Neurogenesis](https://cms.nmn.com/news/tag/neurogenesis)
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- [Rutin](https://cms.nmn.com/news/tag/rutin)
- [Sodium Rutin](https://cms.nmn.com/news/tag/sodium-rutin)
- [Liver Health](https://cms.nmn.com/news/tag/liver-health)
- [Blood NAD+ Levels](https://cms.nmn.com/news/tag/blood-nad-levels)
- [Nephropathy](https://cms.nmn.com/news/tag/nephropathy)
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- [Bone Regeneration](https://cms.nmn.com/news/tag/bone-regeneration)
- [Cisplatin](https://cms.nmn.com/news/tag/cisplatin)
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- [Cochlea](https://cms.nmn.com/news/tag/cochlea)
- [Auditory Hair Cells](https://cms.nmn.com/news/tag/auditory-hair-cells)
- [PARP](https://cms.nmn.com/news/tag/parp)
- [NMN Synthesis](https://cms.nmn.com/news/tag/nmn-synthesis)
- [Skin](https://cms.nmn.com/news/tag/skin)
- [Keratinocytes](https://cms.nmn.com/news/tag/keratinocytes)
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- [Anti-Aging](https://cms.nmn.com/news/tag/anti-aging)
- [Nutraceutical](https://cms.nmn.com/news/tag/nutraceutical)
- [Cytomegalovirus](https://cms.nmn.com/news/tag/cytomegalovirus)
- [Gene Therapy](https://cms.nmn.com/news/tag/gene-therapy)
- [Economics](https://cms.nmn.com/news/tag/economics)
- [David Sinclair](https://cms.nmn.com/news/tag/david-sinclair)
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- [NAD+ IV](https://cms.nmn.com/news/tag/nad-iv)
- [Trauma](https://cms.nmn.com/news/tag/trauma)
- [NFL](https://cms.nmn.com/news/tag/nfl)
- [Chronic Traumatic Encephalopathy](https://cms.nmn.com/news/tag/chronic-traumatic-encephalopathy)
- [Exercise](https://cms.nmn.com/news/tag/exercise)
- [Aerobic Capacity](https://cms.nmn.com/news/tag/aerobic-capacity)
- [Training](https://cms.nmn.com/news/tag/training)
- [Endurance](https://cms.nmn.com/news/tag/endurance)
- [Athletic Performance](https://cms.nmn.com/news/tag/athletic-performance)
- [Aging Rate](https://cms.nmn.com/news/tag/aging-rate)
- [Life Expectancy](https://cms.nmn.com/news/tag/life-expectancy)
- [Infant Mortality](https://cms.nmn.com/news/tag/infant-mortality)
- [Lifespan Equality](https://cms.nmn.com/news/tag/lifespan-equality)
- [Mortality](https://cms.nmn.com/news/tag/mortality)
- [Multimorbidity](https://cms.nmn.com/news/tag/multimorbidity)
- [Centenarians](https://cms.nmn.com/news/tag/centenarians)
- [Inflammatory Burden](https://cms.nmn.com/news/tag/inflammatory-burden)
- [Frailty](https://cms.nmn.com/news/tag/frailty)
- [Longevity Blue Zones](https://cms.nmn.com/news/tag/longevity-blue-zones)
- [Social Support](https://cms.nmn.com/news/tag/social-support)
- [Optimism](https://cms.nmn.com/news/tag/optimism)
- [ABT-263](https://cms.nmn.com/news/tag/abt-263)
- [Spinal Cord](https://cms.nmn.com/news/tag/spinal-cord)
- [Spinal Injury](https://cms.nmn.com/news/tag/spinal-injury)
- [Neurodegeneration](https://cms.nmn.com/news/tag/neurodegeneration)
- [Space](https://cms.nmn.com/news/tag/space)
- [Sleep Quality](https://cms.nmn.com/news/tag/sleep-quality)
- [Space Aging](https://cms.nmn.com/news/tag/space-aging)
- [Midlife](https://cms.nmn.com/news/tag/midlife)
- [Wealth](https://cms.nmn.com/news/tag/wealth)
- [Wealth Disparities](https://cms.nmn.com/news/tag/wealth-disparities)
- [Wealth Inequalities](https://cms.nmn.com/news/tag/wealth-inequalities)
- [NSAIDs](https://cms.nmn.com/news/tag/nsaids)
- [Aspirin](https://cms.nmn.com/news/tag/aspirin)
- [Ibuprofen](https://cms.nmn.com/news/tag/ibuprofen)
- [Immune Cells](https://cms.nmn.com/news/tag/immune-cells)
- [Chondroitin](https://cms.nmn.com/news/tag/chondroitin)
- [Neuroplasticity](https://cms.nmn.com/news/tag/neuroplasticity)
- [DNA Integrity](https://cms.nmn.com/news/tag/dna-integrity)
- [Grapes](https://cms.nmn.com/news/tag/grapes)
- [Grape Seed Extract](https://cms.nmn.com/news/tag/grape-seed-extract)
- [Retina](https://cms.nmn.com/news/tag/retina)
- [Proanthocyanidin](https://cms.nmn.com/news/tag/proanthocyanidin)
- [Vision](https://cms.nmn.com/news/tag/vision)
- [SENS Foundation](https://cms.nmn.com/news/tag/sens-foundation)
- [Aubrey de Grey](https://cms.nmn.com/news/tag/aubrey-de-grey)
- [Mutations](https://cms.nmn.com/news/tag/mutations)
- [Cell Waste](https://cms.nmn.com/news/tag/cell-waste)
- [Innovator](https://cms.nmn.com/news/tag/innovator)
- [Marvel](https://cms.nmn.com/news/tag/marvel)
- [Tissue Regeneration](https://cms.nmn.com/news/tag/tissue-regeneration)
- [Axolotl](https://cms.nmn.com/news/tag/axolotl)
- [Vertebrates](https://cms.nmn.com/news/tag/vertebrates)
- [Healing](https://cms.nmn.com/news/tag/healing)
- [NAD+ Precursor](https://cms.nmn.com/news/tag/nad-precursor)
- [Olympics](https://cms.nmn.com/news/tag/olympics)
- [Elite Athletes](https://cms.nmn.com/news/tag/elite-athletes)
- [Exercise Training](https://cms.nmn.com/news/tag/exercise-training)
- [Gut Health](https://cms.nmn.com/news/tag/gut-health)
- [Cardiovascular Disease Prevention](https://cms.nmn.com/news/tag/cardiovascular-disease-prevention)
- [Nicotinic Acid](https://cms.nmn.com/news/tag/nicotinic-acid)
- [Toxicity](https://cms.nmn.com/news/tag/toxicity)
- [NAD+ Degradation Inhibitor](https://cms.nmn.com/news/tag/nad-degradation-inhibitor)
- [NAD+ Pathway Activator](https://cms.nmn.com/news/tag/nad-pathway-activator)
- [Canines](https://cms.nmn.com/news/tag/canines)
- [Dogs](https://cms.nmn.com/news/tag/dogs)
- [Slc12a8](https://cms.nmn.com/news/tag/slc12a8)
- [Zika](https://cms.nmn.com/news/tag/zika)
- [Microcephaly](https://cms.nmn.com/news/tag/microcephaly)
- [Mosquito](https://cms.nmn.com/news/tag/mosquito)
- [Virus](https://cms.nmn.com/news/tag/virus)
- [Frailty Index](https://cms.nmn.com/news/tag/frailty-index)
- [Aging Biomarkers](https://cms.nmn.com/news/tag/aging-biomarkers)
- [Epigenetic Clocks](https://cms.nmn.com/news/tag/epigenetic-clocks)
- [Telomere Length](https://cms.nmn.com/news/tag/telomere-length)
- [Nutrition](https://cms.nmn.com/news/tag/nutrition)
- [Probiotics](https://cms.nmn.com/news/tag/probiotics)
- [Prebiotics](https://cms.nmn.com/news/tag/prebiotics)
- [Healthy Foods](https://cms.nmn.com/news/tag/healthy-foods)
- [Jeff Bezos](https://cms.nmn.com/news/tag/jeff-bezos)
- [Yuri MIlner](https://cms.nmn.com/news/tag/yuri-milner)
- [Los Altos Labs](https://cms.nmn.com/news/tag/los-altos-labs)
- [Tissue Rejuventation](https://cms.nmn.com/news/tag/tissue-rejuventation)
- [Reprogramming](https://cms.nmn.com/news/tag/reprogramming)
- [Evolution](https://cms.nmn.com/news/tag/evolution)
- [Mammals](https://cms.nmn.com/news/tag/mammals)
- [DNA](https://cms.nmn.com/news/tag/dna)
- [DNA Sequence](https://cms.nmn.com/news/tag/dna-sequence)
- [SNPs](https://cms.nmn.com/news/tag/snps)
- [Genes](https://cms.nmn.com/news/tag/genes)
- [Genomics](https://cms.nmn.com/news/tag/genomics)
- [Comparative Genomics](https://cms.nmn.com/news/tag/comparative-genomics)
- [Fruit Flies](https://cms.nmn.com/news/tag/fruit-flies)
- [Roundworms](https://cms.nmn.com/news/tag/roundworms)
- [Yeast](https://cms.nmn.com/news/tag/yeast)
- [Protein Coding](https://cms.nmn.com/news/tag/protein-coding)
- [Synthesis Errors](https://cms.nmn.com/news/tag/synthesis-errors)
- [NANOG](https://cms.nmn.com/news/tag/nanog)
- [Myogenic Proliferating Cells](https://cms.nmn.com/news/tag/myogenic-proliferating-cells)
- [Musculoskeletal](https://cms.nmn.com/news/tag/musculoskeletal)
- [Myofibers](https://cms.nmn.com/news/tag/myofibers)
- [Dietary Intervention](https://cms.nmn.com/news/tag/dietary-intervention)
- [Tailored Diet](https://cms.nmn.com/news/tag/tailored-diet)
- [Optimize Aging](https://cms.nmn.com/news/tag/optimize-aging)
- [Natural Killer Cells](https://cms.nmn.com/news/tag/natural-killer-cells)
- [Cytotoxicity](https://cms.nmn.com/news/tag/cytotoxicity)
- [Spleen](https://cms.nmn.com/news/tag/spleen)
- [human health](https://cms.nmn.com/news/tag/human-health)
- [Myelin](https://cms.nmn.com/news/tag/myelin)
- [Oligodendrocyte](https://cms.nmn.com/news/tag/oligodendrocyte)
- [Insulin Sensitivity](https://cms.nmn.com/news/tag/insulin-sensitivity)
- [Calorie Restriction](https://cms.nmn.com/news/tag/calorie-restriction)
- [NAD+ Biosynthesis](https://cms.nmn.com/news/tag/nad-biosynthesis)
- [NAD+ Supplementation](https://cms.nmn.com/news/tag/nad-supplementation)
- [Bone Repair](https://cms.nmn.com/news/tag/bone-repair)
- [Fracture](https://cms.nmn.com/news/tag/fracture)
- [Antibodies](https://cms.nmn.com/news/tag/antibodies)
- [Antibody-Drug Conjugate](https://cms.nmn.com/news/tag/antibody-drug-conjugate)
- [Stress-Induced Senescence](https://cms.nmn.com/news/tag/stress-induced-senescence)
- [EGCG](https://cms.nmn.com/news/tag/egcg)
- [ECG](https://cms.nmn.com/news/tag/ecg)
- [Green Tea](https://cms.nmn.com/news/tag/green-tea)
- [SenNet](https://cms.nmn.com/news/tag/sennet)
- [National Institute of Health](https://cms.nmn.com/news/tag/national-institute-of-health)
- [NIH](https://cms.nmn.com/news/tag/nih)
- [Senescence Research](https://cms.nmn.com/news/tag/senescence-research)
- [TERT](https://cms.nmn.com/news/tag/tert)
- [Tissue Health](https://cms.nmn.com/news/tag/tissue-health)
- [Minocycline](https://cms.nmn.com/news/tag/minocycline)
- [Clinical Trials](https://cms.nmn.com/news/tag/clinical-trials)
- [Mice Studies](https://cms.nmn.com/news/tag/mice-studies)
- [Rockfish](https://cms.nmn.com/news/tag/rockfish)
- [UCBerkeley](https://cms.nmn.com/news/tag/ucberkeley)
- [Genetics](https://cms.nmn.com/news/tag/genetics)
- [Berberine](https://cms.nmn.com/news/tag/berberine)
- [Mouse Model](https://cms.nmn.com/news/tag/mouse-model)
- [Amyloid Plaques](https://cms.nmn.com/news/tag/amyloid-plaques)
- [Insulin Resistance](https://cms.nmn.com/news/tag/insulin-resistance)
- [Fat](https://cms.nmn.com/news/tag/fat)
- [Type II Diabetes](https://cms.nmn.com/news/tag/type-ii-diabetes)
- [Glucose](https://cms.nmn.com/news/tag/glucose)
- [Blood Sugars](https://cms.nmn.com/news/tag/blood-sugars)
- [Vaccine](https://cms.nmn.com/news/tag/vaccine)
- [GPNMB](https://cms.nmn.com/news/tag/gpnmb)
- [ovaries](https://cms.nmn.com/news/tag/ovaries)
- [cystic fibrosis](https://cms.nmn.com/news/tag/cystic-fibrosis)
- [bronchiectasis](https://cms.nmn.com/news/tag/bronchiectasis)
- [IBD](https://cms.nmn.com/news/tag/ibd)
- [Safety](https://cms.nmn.com/news/tag/safety)
- [Efficacy](https://cms.nmn.com/news/tag/efficacy)
- [Human Studies](https://cms.nmn.com/news/tag/human-studies)
- [Evaporative Eye Disease](https://cms.nmn.com/news/tag/evaporative-eye-disease)
- [Eye Drops](https://cms.nmn.com/news/tag/eye-drops)
- [Sleep](https://cms.nmn.com/news/tag/sleep)
- [Aged Adults](https://cms.nmn.com/news/tag/aged-adults)
- [Geriatrics](https://cms.nmn.com/news/tag/geriatrics)
- [Heart Rate](https://cms.nmn.com/news/tag/heart-rate)
- [Leukemia](https://cms.nmn.com/news/tag/leukemia)
- [Navitoclax](https://cms.nmn.com/news/tag/navitoclax)
- [Hippocampus](https://cms.nmn.com/news/tag/hippocampus)
- [Learning](https://cms.nmn.com/news/tag/learning)
- [Uthever NMN](https://cms.nmn.com/news/tag/uthever-nmn)
- [Walking Endurance](https://cms.nmn.com/news/tag/walking-endurance)
- [Dorsal Root Ganglion](https://cms.nmn.com/news/tag/dorsal-root-ganglion)
- [Type I Diabetes](https://cms.nmn.com/news/tag/type-i-diabetes)
- [25HC](https://cms.nmn.com/news/tag/25hc)
- [Muscle Restoration](https://cms.nmn.com/news/tag/muscle-restoration)
- [Heart Cells](https://cms.nmn.com/news/tag/heart-cells)
- [Kidney Cells](https://cms.nmn.com/news/tag/kidney-cells)
- [Liver Cells](https://cms.nmn.com/news/tag/liver-cells)
- [Cartilage Cells](https://cms.nmn.com/news/tag/cartilage-cells)
- [AMPK](https://cms.nmn.com/news/tag/ampk)
- [Mitochondria Health](https://cms.nmn.com/news/tag/mitochondria-health)
- [IgE](https://cms.nmn.com/news/tag/ige)
- [Anaphylaxis](https://cms.nmn.com/news/tag/anaphylaxis)
- [Antigen](https://cms.nmn.com/news/tag/antigen)
- [Mast Cells](https://cms.nmn.com/news/tag/mast-cells)
- [D-Ribose](https://cms.nmn.com/news/tag/d-ribose)
- [Blood Glucose](https://cms.nmn.com/news/tag/blood-glucose)
- [Physical Performance](https://cms.nmn.com/news/tag/physical-performance)
- [Overweight Adults](https://cms.nmn.com/news/tag/overweight-adults)
- [dietary restriction](https://cms.nmn.com/news/tag/dietary-restriction)
- [circadian clock](https://cms.nmn.com/news/tag/circadian-clock)
- [Ovulation](https://cms.nmn.com/news/tag/ovulation)
- [MitoQ](https://cms.nmn.com/news/tag/mitoq)
- [BGP-15](https://cms.nmn.com/news/tag/bgp-15)
- [Pirfenidone](https://cms.nmn.com/news/tag/pirfenidone)
- [Blood Donations](https://cms.nmn.com/news/tag/blood-donations)
- [Blood Draining](https://cms.nmn.com/news/tag/blood-draining)
- [Collagen](https://cms.nmn.com/news/tag/collagen)
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